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The CMI calculated from effective weights was 0.77 (hospital) and 0.75 (MDK). The results highlight the design criteria for fine-tuning the PK parameters of a targeted drug delivery system that exploits the benefits of both active and passive targeting. In response to edrophonium, evidence of a partial improvement in lower esophageal sphincter smooth muscle function was found postoperatively when compared with the response of controls and in patients preoperatively.

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Several properties of 10 cell lines derived from the polyoma-induced PW20 Wistar-Furth rat renal sarcoma have been examined, including the ability of the tumor cells to metastasize spontaneously from subcutaneous sites in syngeneic hosts, the platelet-aggregating activity of material extracted by urea from the surface of cultured cells, the sialic acid content of the platelet-aggregating material, and the degree of sialylation of cell surface glycoconjugates in cultured cells. Heavy lifts, pushing/pulling motions and sudden unexpected strain occurred most frequently in the work, while inclined postures, repetitive movements and whole body vibrations characterised different parts of the work. Increased human hybridoma formation by electrofusion of human B cells with heteromyeloma SPAM-8 cells. The Polish training was assessed by means of a pretest, a final examination, a series of skill stations, and a retrospective self-assessment instrument created by the authors. Our findings indicate that the combination of talc and ADP causes a substantially more acute inflammatory reaction than either agent used individually.

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Small-Carrion penile prosthesis for the management of diabetic impotence. The backbone of residues 3-10 in the peptide adopts a series of turns, that involving residues 5-8 being the best defined, while the side chains of residues 1, 3, 4, 5, 6 and 7 form a hydrophobic cluster. Assessment of health-related quality of life in cured SARS patients A 56-year-old man with histologically and bacteriologically proved disseminated tuberculosis in association with pancytopenia responded to antituberculosis chemotherapy with bacteriologic cure of his tuberculosis and concomitant resolution of the pancytopenia. A novel, variant form of this peptide was isolated from the venom of Africanized honeybees (Apis mellifera).

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Humans, apes and monkeys: the changing neuropsychological viewpoint. Intent and outcome in the moral judgment of mentally retarded and nonretarded children.

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Forty normal subjects ranging from 10 to 75 were examined for high frequency VOR responses to active head shaking. These results support the concept that the ulcer-healing effect of carbenoxolone is topical rather than systemic. Alterations in gene expression induced by a specific cell interaction during mating in Tetrahymena thermophila.

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Hepatic artery occlusion was achieved by administration of 20-60 mg adriablastin in 6-12 ml iodized oil and minced gelatin sponge. Beta and beta-delta thalassemia heterozygotes in the province of Alicante.

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To evaluate the association between sleeping pill/tranquilizer (SP/T) use and quality of life (QOL) among cancer patients. Finally, we will outline some expectations in this area of chemistry.

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injected sCT, which was of the same intensity as in non depleted animals. In familial occurrence of the disease higher frequency of preeclampsia has been observed in mothers, daughters and sisters of women burned of this poor medical history and higher risk to severe PE development.

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Self-replicating RNA genomes have an error rate of about 10(-3) - 10(-4) substitutions per base per generation, whereas for DNA genomes the corresponding figure is 10(-9) - 10(-11). MR imaging of hypoxic-ischemic injury in term neonates: pearls and pitfalls. Furthermore, an achromatic lateral shearing interferometer based on the use of three gratings in a series arrangement is discussed and a theoretical proof for the achromatism of this arrangement is given. Risk factors for atherosclerosis include hyperlipidemia, diabetes, smoking and hypertension all of which increase tissue factor (TF) expression. We also defined two adjacent Pbs2-binding sites in Hog1, namely, the common docking (CD) domain and Pbs2-binding domain 2 (PBD-2).

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Our data now suggest a concurrent indirect effect on spinal cord circuitry, probably through the action of botulinum toxin on the intrafusal neuromuscular junction. Early gamma interferon mRNA expression is associated with resistance of mice against Yersinia enterocolitica.

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Incontinence was most frequently associated with abnormally short anal resistance, low anal pressure, reduced sensibility, weak voluntary contraction and absence of rectoanal inhibitory reflex. Association between Ascaris lumbricoides infection and asthma is a controversial subject that has been studied by several authors based on the hygiene theory.

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Novel and extensive aspects of paraquat-induced pulmonary fibrogenesis: comparative and time-course microarray analyses in fibrogenic and non-fibrogenic rats. It effectively reduces various functional groups (like ketones) present in graphite oxide. In contrast, positive DTH responses to both ID93 and components thereof were induced in ID93/GLA-SE-immunized animals, indicating robust but specific cellular responses were present in the immunized animals.

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The findings are consistent with the hypothesis that T wave alternans may be the electrocardiographic manifestation of the transmembrane action potential alternans and could be related in some cases to hypocalcemia. An alternative to conventional interstitial radiotherapy using Au-198

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Radical excision of these AVMs in the anterior and the middle portions of the corpus callosum was accomplished without operative mortality and with minimal morbidity. Despite the apparent advantages of the DLDL-C method, we conclude that for hyperlipidemic children the utility of this new method is not advantageous over the conventional Friedewald method.

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Three digoxigenin-labelled probes were used: two recognized specifically the non-structural region of the B19 genome and one probe was structural region-specific. In cases with GvHD, Ss HLA antigens were found to correlate with the GvHD. Concomitant injuries and complications of supracondylar humerus fracture in childhood These results suggest that a ternary or larger protein signaling complex forms on an F-actin cellular scaffold, providing a spatially restricted signal modulation site that can be regulated by cytoskeletal remodeling.

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Herring sperm DNA injected alone also had antitumor activity against the Madison 109 tumor. Post-exposure prophylaxis plays an important role in prevention of bloodborne diseases after occupational exposures.

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The behavior of doxorubicin and iodized oil in the rat cremaster muscle was studied with videomicroscopy. Public health implications of components of plastics manufacture. A Workflow to Investigate Exposure and Pharmacokinetic Influences on High-Throughput in Vitro Chemical Screening Based on Adverse Outcome Pathways. In this study of isolated ribbons of flagellar doublet microtubules, we demonstrate that a resistance to sliding exists in the interdoublet gap.

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Transformed cells were injected in vivo and haematopoietic cells expressing resistance were selected by drug treatment of recipients. Characterization of a Helicobacter pylori neutrophil-activating protein. TV advertising of alcohol is not in the interests of public health: comments on Ellickson et al. We report three cases of extrahepatic portal-systemic encephalopathy (EHPSE), two of which did not show portal hypertension (PH) and in the other of which precirrhotic state with chronic active hepatitis was detected at liver biopsy.

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The major challenges of today are found in the burgeoning fields of programmed cells death, enzymology of recombination and somatic mutation, development of memory, and the recognition of pathogens by unconventional lymphocytes. Although the three different groups of patients studied tended to show their own particular intra-renal angiographic patterns, the definitive diagnosis depended on the haematological and histoligical findings.

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We report a patient with trichoblastic carcinoma, initially diagnosed as basal cell carcinoma, treated effectively with vismodegib. The level of QL impairment was consistently greater in those patients treated by surgery plus radiotherapy as compared to those treated by radiotherapy alone. Mechanism of action of vasopressin on prostaglandin synthesis and vascular function in the isolated rat kidney: effect of calcium antagonists and calmodulin inhibitors. The luminescence intensity of the mushroom gills and the cultured mycelia was measured in an aqueous suspension under various conditions.

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Continuity of the syringomyelic cavity with the ventricular system was demonstrated. Maxillary incisor lingual fossa depth was measured in East Greenland Eskimos. An intermediate is formed resulting in a partitioning of the reaction between HC(1 or 2).TSG-6 complexes and transfer of HC(1 or 2) to the chondroitin via competing pathways.

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In this point of view, TAZ inhibitors should contribute to cancer therapy. This case emphasizes the importance of prompt skin biopsy for early diagnosis and treatment of this life-threatening infection.

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Striatal neuronal death mediated by astrocytes from the Gcdh-/- mouse model of glutaric acidemia type I. Our understanding of the nuances of skeletal muscle development has been greatly increased by the analysis of mice carrying targeted null mutations in the Myf-5, MyoD and myogenin genes, encoding members of the myogenic regulatory factor (MRF) family. Which should be the essential components of stroke centers in Japan? In addition, we show that we cannot replicate their findings in our own new data. Physico-chemical evaluation of products extruded with sorghum-corn-soybean blends

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Further studies are still necessary to accurately identify the suitable target population, the method of follow-up and the duration of treatment. Synthesis of human interferon by Xenopus laevis oocytes: two structural genes for interferons in human cells. Using breast cancer DNA methylation and clinical data derived from The Cancer Genome Atlas (TCGA), we carried out a systematic inference of TFs whose misregulation underlie different clinical subtypes of breast cancer. Beta-endorphin infusion fails to modulate the hormonal and metabolic response to surgery.

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Spermatozoa were collected from the rete testis and from the cauda epididymis and mixed with fluids from these 2 sites. Interval histogram analysis of period of the electroencephalogram in relation to age during growth and development in normal children. Crystals of the C-terminal fragment belong to space group P2 or P2(1). NMR structures and orientation of the fourth transmembrane domain of the rat divalent metal transporter (DMT1) with G185D mutation in SDS micelles.

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Twenty-five patients without relevant organic disease were examined who complained of long-standing memory disturbance, but were free of relevant organic disease and exhibited a test performance that was normal, or reduced by not more than two standard deviations. In the presence of both ligation and hypercholesterolemia, longitudinal distensibility was decreased while circumferential distensibility increased.

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Our clinical experience using a moderate amount of intermittent retrograde cerebral perfusion is superior to continuous retrograde cerebral perfusion for protecting the brain during aortic arch surgery. The continued expression of P0 antigenicity by the liposomes was shown by specific complement consumption with a multivalent antiserum against P0 or with an IgM monoclonal antibody. These new chiral nickel(I) complexes were found to catalyze the asymmetric hydrodehalogenation of geminal dihalogenides with moderate to good enantiomeric excess values using LiEt3 BH as reductant.

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The amino-terminal immunoglobulin-like domain of sialoadhesin contains the sialic acid binding site. We propose that following ischemic damage to the electron transport chain, the production and release of reactive oxygen species increases from mitochondria in the aged heart, leading to additional damage during reperfusion. The range of the CCHF virus is now known to extend form central Asia to India, Pakistan, Afghanistan, Iran, Iraq, the Middle East, Eastern Europe, and to most of Saharan and sub-Saharan Africa.

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RSV antigen was identified by enzyme-linked immunosorbent assay performed on nasopharyngeal specimens from children meeting clinical case definitions. Release of ribosomes from thylakoids and endoplasmic reticulum with trypsin.

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Anatomical pathways taken by the fistulae are described and certain important points emphasized. On Day 0, in Experiment 3, heifers received either 100 microg of GnRH or 750 microg (DESLORELIN 750) deslorelin implant.

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The effect of the calcium-blockers nicardipine, darodipine, PN-200-110 on insulin release from pancreatic islets was studied using nifedipine as a reference compound. We detected the endosymbionts by PCR-based methods and transmission electron microscopy (TEM) observation of fixed and stained preparations of host cells. The highest sensitivity for both detection of bone marrow disease and extraosseous lesions can be achieved with whole-body MRI and (18)F-FDG PET/CT. Murine liver arylsulfatase B processing influenced by region on chromosome 17.

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Cross-sectional population-based study with random cluster sampling of households, including 722 adolescents (10-19 years), from a city in southern Brazil. Laparoscopic sterilization with electrocautery, silastic bands and spring-loaded clips: report of our experience with 790 patients.

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In order to investigate the molecular evolution and physiological significance of LTA4 hydrolase, the enzymes belonging to the family were aligned and a phylogenetic tree was constructed. Correlation between visual evoked potentials and PET neuro-imaging in subjects with retrochiasmatic lesions. Bead-tracking experiments show that ankyrinB mediates L1-CAM coupling with retrograde F-actin flow in these perisomatic structures. Due to the often-fatal course of PS, the rapid detection of mitochondrial DNA deletions is imperative for diagnosis and family counseling.

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Location of the site of onset of premature ventricular systoles. The clinical application of Doppler velocity measurement is reviewed as a diagnostic tool in arterial disease of the lower extremity.

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Failure to maintain normal ejection indices under conditions of acute or chronic mechanical overload can be explained in terms of an excessive afterload relative to the degree of hypertrophy, the level of inotropic state, and the Frank--Starling rereserve. The history and histological features suggest that the exogenous lipid was introduced by the topical application of a baby oil used after minor trauma to the penis.

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Human fibroblast antioxidant defense response to alteration in oxygen tension. Drugs used for the treatment of cholestatic itch are discussed in detail.