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The First Crystal Structure of the UP1 Domain of hnRNP A1 Bound to RNA Reveals a New Look for an Old RNA Binding Protein. The results obtained from combining the histochemical and biochemical analyses allowed us to obtain more significant information on the localization of cholinergic neurons and the projection areas of the cholinergic terminals. Using a combination of nonreducing sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotting, we detected Fab alpha fragments not only on oral streptococci (Streptococcus sanguis and Streptococcus gordonii) incubated in saliva but also on the bacteria in incipient dental plaque.

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Only small changes in muscle strength were found postoperatively. The biliary excretion rate of antigen-induced cysteinyl leukotrienes rose from less than 2 pmol.min-1.(kg body mass)-1 before challenge to about 30 pmol.min-1.(kg body mass)-1 for 20 min before it declined toward prechallenge level. Event-related potential N270, a negative component to identification of conflicting information following memory retrieval. This elimination occurred through transepidermal channels, slits, or erosions overlying a dermal necrobiotic granuloma. NGF would not substitute for any other classical pathway component, C2-C9.

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The best results are achieved when treatment is initiated before conception. Overlaps appear to be present between the symptoms of PTSD and psychotic experiences.

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Evidence suggesting a requirement for mature T cells in bone marrow inoculum of neonatally injected rats. Behavior, autonomic and immune functions, hypothalamic-pituitary-adrenocortical responses, brain cytokine expression and cardiac histology were investigated in stress-exposed mice. The pathogenetic significance of toxin receptor interaction in disease is examplified by infectious diarrhoea. A significant increase in the dye leakage response was detected for 30-40 min, with the maximum response occurring between 5 and 10 min after topical capsaicin stimulation.

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Previous studies have identified an NLS (nuclear localization signal) in the C-terminal basic region of the DBD (DNA-binding domain), and a leucine-rich, leptomycin-B sensitive NES (nuclear export signal) located further downstream. This is distinctly different in skeletal muscle, whose phenotype is dominant which provided a platform to identify the skeletal muscle determination gene, myoD.

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Scintigrams in prone and standing positions were done in 11 hypertensive women. Increased DNA methyltransferase 1 protein expression in human transitional cell carcinoma of the bladder. The level of serum ferritin of 226 selected subjects, aged 20 to 93, showed an age-related tendency to rise and in every age studied it was higher in males than in females. In this study, high-throughput stress and characterization techniques were applied to 96 formulations of anti-streptavidin antibodies (an IgG1 and an IgG2) to choose optimal formulations. Several hydrophilic polymeric thiols were prepared from amino-activated polymeric supports by reaction with N-acetylhomocystein ethiolactone.

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The pathogenesis of central nervous system paraneoplastic syndromes has not been established. The effect of intravenous dextrose infusion on postbypass hyperglycemia in pediatric patients undergoing cardiac operations. Use of email for patient communication in student health care: a cross-sectional study. Magnitude and pattern of skeletal response to long term continuous and cyclic sequential oestrogen/progestin treatment. Such a convergence is also observed in the case of pallidal responses to electrical stimulation of the striatum.

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Reference is made to classic studies pointing to the existence of lung surfactants in the alveolar lining layer and more recent investigations of their chemical nature. The molecular forms and membrane association of SPC2, SPC3, and furin were investigated in neuroendocrine secretory vesicles from the anterior, intermediate, and neural lobes of bovine pituitary and bovine adrenal medulla. Hepatitis B virus preC mutants in human hepatocellular carcinoma tissues. parapertussis recipients were now able to biosynthesize O-antigen, but no band A was generated. They are quite different from one another in most respects, including quaternary and tertiary structure, but they have similar chemical groups in their active sites.

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Therefore this safe and simple method of TNS is recommended for the therapy of functional placental insufficiency. Further experience with 2100 consecutive ketamine administrations: newer indications and restrictions. Abnormalities in frontal lobe phosphorous metabolism in patients with bipolar disorder have been reported, but many of the patients studied were receiving lithium.

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The feasibility and acceptability of an external quality assurance scheme in veterinary histopathology were assessed for one year. Functional capacities of T lymphocyte subsets from synovial fluid and blood in rheumatoid arthritis.

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Prostacyclin is a key mediator of the vasodilator action of dopamine in humans. Report from the Canadian Coordinating Office for Health Technology Assessment (CCOHTA). Environmental scanning electron microscopy (ESEM) permits to analyze samples in their native-hydrated state, allowing a broad spectrum of biological applications. The expression of NPM mRNA was induced after UV irradiation in UVr-10 cells but not in RSb cells, whereas irradiation did not affect the expression of T-plastin mRNA. Bone marrow showed B-lymphoid blastic crisis 4 months after testicular involvement.

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The histological preparations indicated there was no stromal hypertrophy in the E2-treated castrates, but the E2 treatment did cause dilation of the glandular acini. Although transfection with this oncogene increased the levels of c-Ha-ras mRNA (4- to 5-fold) and induced phenotypic and genotypic changes, respectively, in the CaCo2 and SW480 cell lines, the susceptibility to NK cell lysis was only marginally affected. The aim of the current work was to examine the role of ocular accommodation, that is, the process of changing the shape of the crystalline lens in order to focus an image onto the retina, in active shifts of visual attention between global and local information.

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To explore the molecular and subcellular effects of Angiotensin II during the early phase of an experimental hypertension, biochemical and morphological changes induced by continued administration of subpressoric Angiotensin II doses were traced in rats. We need to design and implement more educational programs on safety injection, and increase promotion of safety injection posters, especially in rural PHCCs. Atropine sulphate (0.08 mg/kg) and isoproterenol hydrochloride (2.5 mg) were then administered by inhalation, each four times a day for seven days in a randomized double-blind cross over fashion to all subjects. The same reaction developed following the injection of pork insulin and monocomponent insulin. Anti-inflammatory agents have also been conjugated to dendrimers and used to treat a number of inflammatory diseases.

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Prospective comparative study of intermediate-field MR and CT in the evaluation of closed head trauma. Within-mouth correlations and reliabilities for probing depth and attachment level. The utility of metaiodobenzylguanidine (MIBG) scintigraphy in patients with pheochromocytoma.

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Regulatory mutants for the synthesis of a 2d purine nucleoside phosphorylase in Escherichia coli K-12. Surgical approaches such as a lateral thoracotomy and a median sternotomy are selected depending on the position and type of aneurysm and other associated malformations.

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Increased responses to lymphokines are correlated with preleukemia in mice inoculated with Moloney leukemia virus. It has however, not been explained in detail in a British journal. Maturation of functional T-lymphocyte subpopulations in the rat.

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Barium enema is safe and informative when obscure clinical presentation or associated illness exists. Alterations of insulin-secreting response to glucose in human infants during the early postnatal period.

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Cold acclimation and the hypothermic effect of ethanol in the rat. Development of construction materials using nano-silica and aggregates recycled from construction and demolition waste. This article explores the diversity of roles within a multi-disciplinary care team and focuses on the requirements of a language from the informatics perspective.

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They received SMC-electrophoresis of peat mud diluted by sulfate sodium-calcium mineral water Uvinskaya of moderate mineralization. The failure of Th1 SN to activate B cells is due to inhibitory effects of IFN-gamma, because it can be reversed by a neutralizing monoclonal antibody specific for IFN-gamma.

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Better control grade was accompanied by higher surgical success rate but with no statistical significance. Following the military coup and the Revolutionary Council Government of the early 60s, further emigration from Burma was cut off. The IgA values were significantly correlated to both the AUC and plasma half-life of zimeldine. Indeed, many neuroscientists regard brain slices as the gold-standard model system for detailed cellular, molecular, and circuitry level analysis and perturbation of neuronal function.

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We report on two asymptomatic sisters who had isolated increased sweat chloride concentrations, and in whom systematic scanning of the whole coding region of the CFTR gene revealed the F508del/S1455X genotype. The glycogen content of the liver was 10 times greater in treated animals 24 hr after 6-OH-DA, whereas cardiac glycogen was more than doubled 72 hr after sympathectomy. Seven children who presented during the influenza A(H1N1) epidemic of 1988 are described. An avirulent strain (A7) of Semliki Forest virus formed nearly as much haemagglutinating and complement fixing antigen in the brains of adult mice as a virulent (V13) strain, yet the infectivities of the brain tissues were different by about 100-fold. Ultrasonography may not detect either vesicoureteric reflux (VUR) or renal scars or inflammation.

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This did not result from a reduced dNTP supply because dNTP pools were unchanged in resting cells infected with the mutant virus. The association with upper-extremity force measured by handgrip strength (HGS) and 6-min walk distance (6MWD) has not been previously described. In order to measure these photolabile systems, we have developed a general technique which allows Raman measurements of any photosensitive material. After 24 h, patient complained of pain in gluteal region, oliguria, and high levels of creatine phosphokinase that reached to 58,395 IU/l. Independent predictors of prolonged hospitalization were: the number of functions lost to the ADL index, pressure sores, hip fracture, peripheral arterial disease with critical ischemia, and low levels of sodium.

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Moreover, the methods of reconstructing path concentration distribution along the beam path by applying a Gaussian model and the derivative of 6th degree polynomial fitting function were established in this article. The primary focus of the malignancy could not be precise in spite of all diagnoses procedures available including explorer laparatomy. Strumal carcinoid of the ovary: ultrastructural observations and long-term follow-up study. The structural aspects are discussed in terms of the well-known mechanism of action of the glycopeptide antibiotics.

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Application of different detergents in preparing the acellular kidney (Triton X-100 and sarcosyl) and in the treatment of individual proteins under study leads to linear relationships of different slopes which is ascribed to the differences in electrostatic repulsive forces introduced by the detergent. Although cAMP-dependent epithelial chloride secretion is largely regulated via apical membrane chloride channels, cAMP also remodels basolateral F-actin and activates basolateral Na-K-2Cl cotransport. 6-OHDA (250 mug intraventricular route) reduced the rate of responding in the regions where responding was for short, medium, and long stimulus trains.

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The recent data about the treatment of advanced breast cancer patients with synthetic LH-RH analogues are presented. Enhanced synthesis of a specific protein by 12-O-tetradecanoylphorbol-13-acetate in cultured chick embryo muscle cells.

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Moreover, these negatively charged molecules are potent inhibitors of cytolytic T-lymphocyte-mediated lysis of target cells, suggesting a functionally crucial role for perforin in cell-mediated cytolysis. After injection of horseradish peroxidase into single blastomeres in Xenopus embryos at 2- to 512-cell stages, all of the descendants could be traced and counted at tailbud stages. In contrast, an unspecific hydrolase active on several N-substituted aminoacyl-tRNAs is practically absent in the encysted embryos and during embryogenesis and appears abruptly during larval development. These errors are especially important in scanning probe microscopy images where the pixel value reflects a distinct height.

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The context for this discussion is a teaching and assessing course which holds the concept of change as the central philosophy for curriculum structure. Newly produced G-CSF had an approximate molecular weight of 24,000 daltons as judged by chromatography on Sephadex G-150. Clinical and statistical research on the occurrence of pseudarthrosis of ulna and radius in forearm fractures. LV volume was determined from three orthogonal diameters measured by sonomicrometry.

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From a transfemoral approach, with the patient under local anesthesia, a 2.2 French microcatheter was guided through the vertebral artery and placed directly into the aneurysm. Purification and properties of the alpha-interferon receptor of human lymphoblastoid (Namalva) cells.

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FMRF-amide and L-Arg-L-Phe increase blood pressure and heart rate in the anaesthetised rat by central stimulation of the sympathetic nervous system. Insulin allergy and insulin resistance can cause life-threatening problems for diabetic patients. A few simple laboratory tests will be of assistance: BUN, creatinine, osmolality, uric acid, serum potassium, and spot urinary sodium and osmolality. Transplantation of embryonic neocortex into adult host neocortex leads to the survival of many donor cells, with the subsequent differentiation of the cortical neurons within a loosely laminated cellular pattern.

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Unlike traditional remote medical technologies (RMT) building on dedicated medical equipment, we are applying easy-to-use personal health system (PHS) components geared towards the wellness and sports market. In addition, this formulation retains the effects on lipid metabolism of OCs containing desogestrel. In contrast little is reported about the roles of ROR beta and ROR gamma. Defoveating fast phases with decreasing-velocity slow phases may be the result of the addition of saccadic pulses to linear slow phases. Uncoupling lymphocyte proliferation from differentiation: dissimilar dose-response relations for pokeweed mitogen-induced proliferation and differentiation of normal human lymphocytes.

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We have described a surgical procedure that totally denervates the rat cremaster muscle. The active components in SC products are highly potent and poorly characterized. Oncogenes in human tumor cell lines: molecular cloning of a transforming gene from human bladder carcinoma cells.

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Clinical efficacy of short-term treatment with extra-fine HFA beclomethasone dipropionate in patients with post-infectious persistent cough. Despite different beta-lactamase concentrations, the decrease in the viable cell count was nearly identical in all experiments.

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Crystallization and preliminary X-ray analysis of human alpha-galactosidase A complex. Ribosomal frameshifting at the Gag-Pol junction in avian leukemia sarcoma virus forms a novel cleavage site. Injection of iothalamate led to large extravasation of 99Tcm-DTPA, 125I-HSA and Trypan blue which means severe damage of the blood-brain barrier. Under the conditions described, glycoprotein receptors maintain their function in that they bind external agents specific for them, such as concanavalin A and immunoglobulins. The circulating noradrenaline levels were higher during the infusion of pork insulin which also yielded a more prominent response of pancreatic polypeptide and, after cessation of the insulin infusion, plasma cortisol was also higher following pork insulin.

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Distribution and functional characteristics of N- and M-cholinoreceptors in structures of the striopallidal complex In an analysis of allozyme genes in three pine and one spruce species distributed in Eurasia, 45 of 87 loci were mapped. Contrary to a previous report, division of the ovarian ligament is required. Furthermore, mutationally active p160ROCK phosphorylated an NHE1 C-terminal fusion protein in vitro, and this was inhibited in the presence of Y-27632. In every patient, both 0.5-T and 2.0-T MR studies were done within 1 week.