Proclorperazina is a first-generation antipsychotic, Proclorperazina mainly blocks D2 dopamine receptors in the brain. It can also block histaminergic, cholinergic and noradrenergic receptors. One study also found that Proclorperazina inhibits the P2X7 receptor in human macrophages, but not in mouse cells, preventing a calcium ion influx. This mechanism was independent of dopamine antagonism. Proclorperazina can be administered orally, parenterally, intramuscularly and rectally. All four routes can be given to control nausea and vomiting. For nausea and vomiting pre- and post-surgery, the intramuscular and parenteral routes are both viable options. For psychiatric conditions, the administration can be via both intramuscular and oral routes. For headaches, parenteral is the route used.
Other names for this medication:
Prochlorperazine,
Compazine,
Antinaus,
Buccastem,
Carmetic,
Darbazine,
Dhaperazine,
Emetiral,
Emidoxyn,
Mitil,
Nautisol,
Novamin,
Prochlor,
Proclorperazina,
Procomp,
Promat,
Roumin,
Stemetil,
Stemzine,
Steremal,
Vergon,
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