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Mechanistically, Sdc1 significantly modulated expressions of ZO-1 and occludin by activating Stat3, which directly bound to the promoter regions of ZO-1 and occludin. Hip fracture incidence seems to be lower in Japan than in many Western countries, but the difference is apparently becoming smaller with progressive Westernization of the Japanese lifestyle and nutritional habits.

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The demonstrated efficacy is clinically relevant and the safety profile is acceptable. Combined orthodontic-surgical treatment of discrepancies in growth of bones of the jaws: motivation and satisfaction

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There are marked geographical variations in rates of medical and surgical intervention at every level of aggregation and in every aspect of medical practice. The limitations of the lattice model are discussed in connection with the results obtained. Our findings are in keeping with the assumption that interactions between megakaryocytes and fibroblasts involve in cytokine-mediated functional network regulated by factors such as spatial relationship, cytokine stimulation, and low concentrations of mediators, particularly PDGF and TGF beta. The effect of extra-fiber structural and pathological components confounding diffusion tensor imaging (DTI) computation was quantitatively investigated using data generated by both Monte-Carlo simulations and tissue phantoms.

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All transfection groups showed effective reduction in 2,3-linked sialylation whereas the trend of reduction levels of triple siRNA transfection outweighed both the dual siRNA groups and single siRNA transfection groups. Different effects of substance P and vasoactive intestinal peptide on the motor function of bovine intraocular muscles. Documentation of fourth ventricle entrapment by metrizamide ventriculography with CT scanning. During the various times of preincubation of T cells at 37 degrees C, an increased release of receptors on the surface of T mu and partly T gamma cells was observed.

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Although the physiological significance of this pehnomenon is not clear, the involvement of haemoproteins in intracellular iron metabolism seems likely. The patient was given a reading prescription to aid with accommodation and was to use artificial tears and lacrilube ointment. Their spatial distributions were quite close to each other, and yet they were significantly different.

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Strongly immunoreactive cells are found in the lateral septal region, the bed nucleus of the stria terminalis, the central amygdala, and the dorso-lateral hypothalamus. Data on 117 pharmaceutical compounds in the CMR toxicology database have been analyzed to determine what new toxicological information was provided by the dog in chronic (6 months or longer) toxicity testing. Thyrotropin-dependent insulin-like growth factor I mRNA expression in thyroid cells. Massive hydrothorax producing hemodynamic compromise (tension hydrothorax) has been documented as an infrequent complication of both acute temporary peritoneal dialysis and continuous ambulatory peritoneal dialysis (CAPD). Analysis of the data indicates that when serum is present exogenous EGF exerts a trophic effect which increases with time (P less than 0.001).

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Maintenance chemotherapy with CCNU, cyclophosphamide, methotrexate, procarbazine alternating with vinblastine, nitrogen-mustard, methotrexate, procarbazine, frequently had to be discontinued because of severe toxicity. We conclude that with sufficiently severe pulmonary hypertension in association with diffuse lung injury, lobar pulmonary artery occlusion may cause alterations in cardiac output and left atrial pressure. The study method differentiated between recovery from the two doses of disoprofol and thiopentone at the first two endpoints only. Morphologically unchanged asymmetric synapses were present in all experimental groups.

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Thus from the results of this paper it may well be recommended in dealing with patients who are submitted to total gastrectomy. Efforts to identify agents that activate death receptors or block specific effectors may improve therapeutic design. These studies provide models of brain-behaviour relationships and related statistical procedures that may allow more precise documentation of the anatomy of brain functions and its pathology, and further investigation of the modalities of brain-behaviour relationships. Dicentric chromosome aberration analysis using giemsa and centromere specific fluorescence in-situ hybridization for biological dosimetry: An inter- and intra-laboratory comparison in Indian laboratories. Self-complexity was found to comprise two components: positive self-complexity and negative self-complexity.

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As PET technology has advanced, the noninvasive quantification of absolute regional myocardial blood flow has become possible. Smooth muscle cell proliferation by conditioned media from cyclosporine-treated endothelial cells: a role of endothelin. Inhibitors of cyclic nucleotide phosphodiesterases inhibit protein carboxyl methylation in intact blood platelets.

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This hypothesis was supported by the finding that tumor vaccine induced peritoneal cells of tumor-bearing animals were abrogated in their suppressor activity in polyclonal in vitro spleen cell blastogenesis when these animals were further treated with MMC. The clinical significance of research findings is an important issue that, until recently, was often neglected. Absorption spectra indicate conformational alteration of myoglobin adsorbed on polydimethylsiloxane. Alterations in ventricular mass and performance induced by exercise training in man evaluated by echocardiography. The human ABCC1 gene, a member of the ATP-binding cassette transporter super-family, plays a critical role in conferring cancer cell resistance to chemotherapeutic drugs.

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Among the cases of superior oblique muscle palsy tested, ocular vertical deviation was classified into three types depending on the angle of head tilt. In experimental animals a significant decrease in mesenteric blood flow and an increase in mesenteric vascular resistance could be shown.

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In this paper, we report the production of recombinant glutathione S-transferase-maspin fusion protein, expressed in the bacterium Escherichia coli, and recombinant maspin, expressed in the insect Spodoptera frugiperda cells. In addition, occasional focal areas of ischemic injury showing filiform neurons with reactive astrocytic gliosis background consistent with acute lesions were observed in CA3. Late repeat Descemet-stripping automated endothelial keratoplasty. However, there is little known about the mechanisms governing the transcriptional regulation of taste receptor genes.

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The use of antimicrobial irreversible hydrocolloids thus may aid in reducing operatory to laboratory cross-contamination. Results are justified by the liposolubility and protein-binding properties of the drugs. Functional relationships of lymphocyte membrane structures probed with cytolysis and/or proliferation-inhibiting H35-27.9 and H35-89.9 monoclonal antibodies.

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Results indicate that cost-sharing has little influence on the probability of using any dental services and basic expenditures. We conducted a pilot study to assess the cornea after refractive surgery using UBM. Mandibular condyle lesions in children with juvenile idiopathic arthritis.

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A case of OKT8-T cell lymphoma with M proteinemia--a study of a soluble factor vulgaris remained passive to the thermal heterogeneity of aquatic environment. Although those cells transport thymidine with two kinetic components (Km values of 160 microM), they lacked the lowest Km system present in AKR splenocytes. However, in frozen-thawed semen, the motility remained almost the same and increase in AR of frozen spermatozoa was not pronounced. For the latter, a novel in vitro test system is described as a relatively simple screening procedure.

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Dose-area product (DAP), air Kerma (AK), fluoroscopy time, number of digital subtraction angiography images, and patient mass were collected to calculate and normalize radiation dose indexes for procedures completed with the standard and novel fluoroscopes. Today, evidence suggests that the human enzymes that catalyze the reaction have been rounded up.

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Blood culture as a guide for the diagnosis of central venous catheter sepsis. Three-dimensional angles and their cyclic changes are important for coronary stenting. High rate of incidents reported for inpatients with learning disabilities.

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These findings suggest that the renin-angiotensin system is actively involved in hypertensive disease of pregnancy and that suppressed levels of renin concentration and activity may result from elevated angiotensin levels. The p21 protein is a negative regulator of mammalian cell cycle progression that functions both by inhibiting cyclin dependent kinases (CDKs) required for the initiation of S phase, and by binding to and inhibiting the DNA polymerase delta co-factor, proliferating cell nuclear antigen (PCNA). Also the stimulation of cardiac chemosensitive fibres evoked a larger decrease on blood pressure and heart rate after MI and these were also partially reversed by losartan.

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From a theoretical point of view, it is undoubtedly a challenge to try to account for the observed tunneling in the protein by microscopic simulations without adjustable parameters. We describe a woman with acquired immunodeficiency syndrome (AIDS) and elevated antiphospholipid antibodies who developed necrotic skin lesions and was subsequently shown to have antiphospholipid syndrome. Risk of a second malignant neoplasm in persons with cancer in childhood and adolescence High voltage electron microscopy permits direct observation of cell fine structure in three dimensions, including the spatial relations of organelles. Both ACE inhibitors and ARBs also help stave off complications from heart failure and kidney disease.

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Prolonged relief of tic douloureux from partial root destruction is associated with localized analgesia. The results indicate a competitive inhibition of estrogen action at the receptor site. Evidence that a substantial proportion of consumers and carers preferred hospital to community care is placed against this background.

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The protein-producing function of the odontoblasts was studied in 120 Wistar rats with an initial weight ranging from 30 to 40 g determining the rate of the migration of radio-active isotopes (glycine-2-14C, lysine-1-14C) from the odontoblasts to the predentine. High Dk silicone hydrogel contact lenses became available for research and clinical practice almost 10 and 5 years ago respectively. Cotinine competitively inhibited mitochondrial 11 beta-hydroxylase, but did not inhibit microsomal 21-hydroxylase.

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An improved design for an intramuscular pH needle electrode, which slows the rate of accumulation of protein deposits and increases the stability of the needle electrodes, has been developed. We measure contrast thresholds for global motion identification and simple detection using sparse random-dot kinematograms. Reactive astrogliosis in response to hemorrhagic fever virus: microarray profile of Junin virus-infected human astrocytes. Specific enhancement of the therapeutic effect of anti-idiotype antibodies on a murine B cell lymphoma by IL-2.

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The impact of isolated central nervous system relapse following initial complete remission in childhood acute lymphocytic leukemia. Elevated salivary F concentrations were maintained throughout the device phase when broken or depleted IFRDs were replaced. The oxidative stress during reoxygenation was demonstrated by decrease of GSH concentration and increase of TBA-RS level. Chemosensitivity of rat medullary raphe neurones in primary tissue culture.

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We used conventional content analysis to explore their knowledge of nodules and the follow-up plan, and their distress. None of these previously heavily treated patients achieved a marrow remission. In patients with apparently normal valves, other potential sources of embolism are frequently detected. The genes were identified by DNA sequencing, and their relative expression was determined by Northern blot analysis. Based on the clinical picture and the pattern of a series of organic acids in the urinary metabolic profile our four patients can be divided in two types of dicarboxylic aciduria.

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HuBChE to soman molar ratio of 0.11 was sufficient to prevent the manifestation of toxic signs in guinea pigs following exposure to 2.17x the inhaled LD50 dose of soman (ILD50, 101 micrograms/kg). The total quantity and the concentrations of E1 and F2alpha decreased with passage of ingesta through the duodenum and jejunum. 15 of 19 patients with a supposedly healed meniscus had normal knee function, i.e., unchanged compared to preinjury levels, but a slight drop in median activity score. Transformed and normal cell surface glycoproteins that induce interferon production by nonsensitized lymphocytes.

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Follistatin, which neutralizes the erythroid differentiation factor (EDF), had no effects on this activity. Here, we report that EOS infiltration of the lesion site increased gradually with the progression of cervical cancer. Calcium ions, propranolol, blood transfusion caused a significant decrease in adherence.

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Correlation between the direct intra-arterial method and the sphygmomamometric auscultation in the determination of the systemic arterial pressure A comparison group comprised users of lenses that do not restrict the field of clear vision. Changes in chick brain RNA polymerase associated with an imprinting procedure. Bioresorbable scaffolds (BRS) are a promising new interventional treatment strategy for coronary artery disease (CAD).

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During their proliferation and successive antibody formation, they migrate only slowly, so that they remain close together. Cellular DNA, RNA, and protein synthetic activities were reduced in the presence of gossypol. Four days after spawning the hepatocytes tend to regain their pre-spawning appearance.

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The median length of follow-up was 6 years for the study infants and 5.07 years for the controls. Formation of prostaglandin A2 (or B2) was not observed under the same conditions. Transplacental carcinogenesis by cisplatin in F344/NCr rats: promotion of kidney tumors by postnatal administration of sodium barbital. Effects of azelastine on vagal neuroeffector transmission in canine and human airway smooth muscle. The article also presents models for understanding the problem, as well as provides recommendations for practice.

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Factors influencing the decision to perform urinary undiversion are evaluated. Primary osteosarcoma of the cervical spine: a pediatric case report and review of the literature.

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7 alpha-Hydroxylation was detected exclusively in rat, and 6 alpha-hydroxylation was detected in both dog and rat. The expression of monomorphic Ia-like antigens and polymorphic (allotypic) HLA-DR determinants on CFU-GM, BFU-E, CFU-E, and CFU-GEMM was studied in bone marrow and peripheral blood cells from normal healthy individuals. Reliability of the Rey-Osterrieth Complex Figure in use with memory-impaired patients.

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The effect of the combination on pneumococci in vivo was bacteriostatic rather than bactericidal, possibly because the number of pneumococci in the cerebrospinal fluid of the rabbits at the start of treatment was larger than that in the inoculum used for in vitro sensitivity tests. The sequence of radiographically visible changes about the shoulder girdle following irradiation was analyzed in 49 patients who received 200 kV irradiation, in 50 who received 25 MeV betatron photon irradiation, and in 20 who received cobalt-60 irradiation. Statins induce suppressor of cytokine signaling-3 in macrophages. Depending on the clinical situation, SRS may be the treatment of choice in selected patients.

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Halothane-induced liver damage: an analysis of the material reported to the Swedish Adverse Drug Reaction Committee, 1966-1973. Shared gene expression alterations in schizophrenia and bipolar disorder. Profile of the patient with failed back surgery syndrome in the National Institute of Rehabilitation.