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Pladex (Clopidogrel)
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Clopidogrel

Pladex bisulfate (Pladex) is an anti-platelet drug, that is, a drug that inhibits the ability of platelets to clump together as part of a blood clot. Pladex prevents blood clots by irreversibly binding to the P2Y12 receptor on platelets, preventing adenosine diphosphate (ADP) from activating platelets. It belongs to a class of drugs called P2Y12 inhibitors. Other drugs in this class include ticagrelor (Brilinta) and prasugrel (Effient). Pladex is similar to ticlopidine (Ticlid) in chemical structure and in the way it works. Unlike ticlopidine, Pladex bisulfate does not cause serious reductions of white cells in the blood and, therefore, routine blood testing to determine if the white blood cell count is low is not necessary during treatment. The risk of heart attacks and strokes (which usually are caused by blood clots) is increased in patients with a recent history of stroke or heart attack, and patients with peripheral vascular disease. (Peripheral vascular disease is the same as atherosclerotic arterial disease or "hardening" of the arteries in which the arteries become narrowed. It frequently occurs in the legs and often causes claudication or pain in the legs upon walking.) Pladex bisulfate is used to reduce the risk of heart attacks and strokes in these patients. Pladex bisulfate was approved by the FDA in 1997.

Other names for this medication:
Clopidogrel, Plavix, Anclog, Anlet, Antiplar, Artevil, Clavix, Clopicard, Clopilet, Clopivas, Deplatt, Diloxol, Duoplavin, Expansia, Farcet, Globel, Grepid, Iscover, Karum, Klopidogrel, Nabratin, Narutis, Nefazan, Noklot, Pidocar, Pidogrel, Pladex, Plagerine, Planor, Tisten, Troken, Trombex, Vaclo, Zyllt,

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The age distribution showed a marked prevalence of infants and young children. Moreover, the STAT3-mediated activation of p21waf1 was also inhibited in breast cancer cells containing elevated levels of cyclin D1. Didemnins: antiviral and antitumor depsipeptides from a caribbean tunicate. Genetic mutations in epigenetic modifiers as therapeutic targets in acute myeloid leukemia.

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Health-related quality of life in patients with Chagas disease: a review of the evidence. The voltage from the collimator setting must match the BCD signal or a comparator logic will drive the fault matrix to prevent the accelerator from energizing. Improvement of transthoracic pulmonary venous flow Doppler signal with intravenous injection of sonicated albumin.

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Antithrombin III level on the intravenous injection of tissue thromboplastin and heparin to rats with depressed blood anticoagulating system function due to an atherogenic diet ET1-treated hMSCs also expressed upregulated mRNA transcript levels of OCT3/4, NANOG, CBFA1 and SOX9. Because hospital length of stay is the most important determinant of cost of hospitalization, this study was performed to analyse factors contributing to hospital length of stay in an hepato-gastroenterology unit.

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Two cases with immunohistochemical and ultrastructural findings. Within the limitations of the present study, both procedures proved to be efficient in gingival recession treatment. Heart rate, arterial pressure, and left ventricular pressure were monitored continuously for each animal. The influence of homonymous visual field disorders on colour sorting performance in the FM 100-hue test.

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The presence of chloramphenicol during this incubation abolished the reactivation. Prospective HLA-DR matching has been shown to enhance renal graft survival. Theory and experimental method for determining individual kinetic constants of fast-acting, irreversible proteinase inhibitors.

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Cancer mortality and wood dust exposure among participants in the American Cancer Society Cancer Prevention Study-II (CPS-II). Use of endothelial protector Softel in surgery of the anterior eye segment

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In BC1 and F2 generations the chromosome compositions are determining which arise as a result of stochastic processes in premeiotic mitoses and in meiosis in F1 hybrids. These results indicate that the large subunit of cytochrome b exists in fish neutrophils and the epitope is exposed to the cytoplasmic side of membrane, and suggest that cytochrome b is conserved across species. Although chemotherapy and allogeneic transplantation may be used in selected patients, the mainstay of therapy remains supportive care, with differentiating therapy being largely disappointing so far and the role of hematopoietic growth factors remaining unresolved. Evolution of human esophageal cancer cell in the process of cell line establishment

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Plain X-ray of the abdomen is the best method of assessing the size and response of the cysts to treatment and for following the patients subsequently. pH-dependence of catalytic constants of the enzyme reaction--some remarks. However, most prior work was devoted to the reduction of fluctuation and the robustness of cellular function with respect to intrinsic noise. Alterations in bone marrow and thymus lymphocytes in virus-inoculated, inbred, preleukemic AKR/J mice.

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The latter was characterized by measurements of absorbance and fluorescence spectra and of effects of irradiation on subsequent capacity of cells for transport of the nonmetabolized amino acid cycloleucine. Fine-needle arthroscopic findings in pathological changes in the temporomandibular joint Information on health problems was collected over the 1.5 yrs that followed. Once the drug was dissolved in a physiological and the other time in a K-Mg-concentrated electrolyte solution.

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A study of antipolynucleotide antibodies, anti-Klebsiella (K30) antibodies and anti-DNA antibody idiotypes in ankylosing spondylitis. Inorganic and organic anions can be separated on an ordinary silica C18 column using a mobile phase containing tetrabutylammonium hydroxide (TBAH) and an aminosulfonic acid zwitterion reagent (MOPS). We aimed to evaluate the most common complications and possible shortcomings in the emergency patients who were admitted to the clinical wards or intensive care units.

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The pattern of inheritance of the chromosome heteromorphisms indicates that this individual was probably conceived by the fertilization, by two different spermatozoa, of an ovum and the second meiotic division polar body derived from the ovum and subsequent fusion of the two zygotes. The unit response to acoustic stimuli increased after forward or backward pairing of the stimuli with glabella tap and hypothalamic electrical stimulation.

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In patients with insufficient bone available for conventional implant treatment, the use of an adjunctive inferior border graft may be considered. The change in leukocyte adherence reaction for determining leukocyte sensitization and adhesion Thus no significant advantages in terms of clinical results could be detected with this type of membrane oxygenator versus another type of bubble oxygenator for elective cardiac operations in adults. Umbilical cord blood (UCB) derived HPC were cultured in the Cytomatrix in the absence of exogenous cytokines.

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The role that the secondary gain of work-related back pain plays in the length of disability is an issue that has been debated for years without absolute resolution. Simulations and measurements showed that the nuclear reactions 88Sr(n, 2n)87mSr and 44Ca(n, p)44K are highly useful for the purpose. The cervical sympathetic ganglia did not contain CGRP-immunoreactive perikarya. In situ visualization of the active peptides after NaDodSO4/PAGE, confirmed that only high Mr DNA polymerase fragments were present in embryo extracts and in purified preparations of DNA polymerase alpha.

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The use of several effective phytocompounds, including lycopene, working through preventive and/or corrective pathways in the cell, may be an approach for reducing UV-B-generated damage. Pharmacoeconomic models may serve to mislead practitioners regarding treatment decisions. Heat-resistant survivors were screened for deletions with endpoints in the bio operon and to the right of lambda P and to the left of lambda A. Both fugacar drug testing young and old SHR rats, however, were more sensitive than WKY rats to the pressor effects of epinephrine.

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Active vaccination bactrim dosage pediatrics of patients with HIV infection (vaccine therapy) safely alters the immune repertoire against HIV. Effect of pH on photoinduced electron transport in reaction center preparations from Rhodopseudomonas sphaeroides

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Vascular endothelial cell growth factor binds competitively with placental growth factor to the extracellular ligand binding domains of FLT, indicating that both ligands probably complex to overlapping or identical regions of this receptor. The photoinduced degradation of CP43 and the cross-linking among the D1 protein, CP43, and CP47 were less obvious in the PS II membranes that had been treated with hydroxylamine rather deptran doxepin hydrochloride cream than Tris and in the membranes that had been treated with Tris and reconstituted by addition of an extrinsic 33-kDa protein (OEC33).(ABSTRACT TRUNCATED AT 250 WORDS)

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The observed antiproliferative action of melatonin was associated with an arrest at S-phase, decreased oxygen consumption, down-regulation of BCL-2 expression and an increase in oxidative stress culminating with caspase-3-independent cell death. Laser in situ keratomileusis versus photorefractive keratectomy: an update on indications and safety. Following administration of TRH (2.5 mg/kg, s.c.) for 21 successive days, bumex renal dosing clindamycin the stimulatory effect on locomotion progressively increased whereas the inhibitory effect decreased, the hyperlocomotion continuing at a later period.

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