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It is established that the chronic intoxication with copper in doses 1 and 0.1 mg/kg leads to the disturbance of electrolyte exchange in the organism and to changes in the level of vitamin C in blood, in doses 1 mg/kg--to disturbance of the protein exchange, and in doses 0.01 mg/kg no changes are established in all examined indices. 5-fluorouracil and high dose folinic acid in hormone-refractory metastatic prostate cancer: a phase II study. The electric double layer in bone and its influence on stress-generated potentials. Both fertility and fecundity were affected by food deprivation in some, but not all manipulations. These findings indicate that S and alloantigens are associated with each other or at least located very close to each other.

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All cognitive functions showed improvement over a 1-year period. Policy and environmental indicators for heart disease and stroke prevention: data sources in two states. The system was established to enhance the care of infertile couples at the community level, to assure a sufficiently large volume of patients at UNC Hospitals to support appropriate quality control measures, and to allow couples undergoing ART to have most of their care in their own community. IFN-gamma production was abrogated completely by cyclophosphamide and antithymocyte serum, and partially by hydrocortisone and carrageenan, but not by anti-asialo GM1 antibody in Listeria-infected mice treated with these agents before induction of IFN-gamma by LCWF. Substantial heterogeneity was observed across both improved and unimproved transects, except for one improved transect that exhibited substantial homogeneity, so that profiles for a single core were largely representative of the entire transect.

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While many important protein-coding genes that are necessary for proper male development have been identified, many disorders in human sex development are still unexplained at the molecular level. The structures of the new deacetoxyyanuthone A (1) and its 2,3-hydro derivative (2) were assigned by spectroscopic methods, including 2D NMR and CD for the Cotton effect of alpha-epoxyketone experiments. For these reasons, the search for new chemical agents to treat human disease has traditionally been undertaken only within the walls of industry. The expression of surface markers and cytokine production in Langerhans cells and keratinocytes and the elicitation response of contact hypersensitivity were compared.

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By contrast, lamin-B2 expression increased and LAP2alpha expression decreased twofold. Both acute inflammatory and chronic demyelinating lesions were seen in the CNS. Surgical complications in pediatric and adolescent renal transplantation can be minimized if basic principles of careful transplant techniques are used. Further characterization of the executive memory impairment following frontal lobe lesions.

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Furthermore, double knock-down by coinjection of smyd3 and setd7 MOs caused the synergistic defects in heart development. To date, treatment programs for adult domestic violence (DV) or intimate partner violence (IPV) have had minimal impact. Numerous studies have now shown the presence of nuclear DNA strand breaks in human ejaculated spermatozoa and the abnormal persistence of apoptotic marker proteins.

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Detection of water proximity to tryptophan residues in proteins by single photon radioluminescence. After obtained control studies, normal human subjects ingested 0.6 g of aspirin, 150 mg of dipyridamole, or a placebo and studies were repeated 1 1/2 hrs later. We propose a score to jointly evaluate and report cancer control and functional results. The results obtained in this study demonstrate that the presentation of self-Ia antigens, in conjunction with the recognition of allo-major histocompatibility complex antigens, are required for in vitro primary MLR. Direct comparison of metabolic health effects of the flavonoids quercetin, hesperetin, epicatechin, apigenin and anthocyanins in high-fat-diet-fed mice.

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In polar neutrophils, F-actin became concentrated in the front of the cell. Identification of serotonin 5-HT4 recognition sites in the porcine caudate nucleus by radioligand binding. Meningococcal disease: epidemiology and control of secondary cases In this work we report the induction of digits that have otherwise normal morphology but lack an interphalangeal joint.

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Local administrations of prostaglandins E1 or E2 combined with orthodontic tooth movement can approximately double the rate of tooth movement in monkeys compared to that of the control. Epidermal growth factor (EGF) concentration in the mouse kidney was exceedingly low when compared with the submandibular gland level. The management strategy used for heparin and protamine added accuracy and precision, which was associated with improved hemostasis. Debatable questions in the classification and therapy of the infectious complications of abortion

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An illustrative history of a young woman with chronic anorexia nervosa is followed by a discussion of treatment alternatives. Supine craniospinal irradiation using a proton pencil beam scanning technique without match line changes for field junctions.

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Defibrotide protects endothelial cells, but not L929 tumour cells, from tumour necrosis factor-alpha-mediated cytotoxicity. As in female patients, the clinical course in male patients with breast cancer is determined mainly by tumor stage.

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Implementation and analysis of Public Law 98-460--section 1619 (the Social Security Disability Benefits Reform Act of 1984). Beta-thromboglobulin levels in diabetes mellitus: influence of degenerative lesions and glycemic regulation using an artificial pancreas.

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threo-beta-Fluoroasparagine is highly toxic to some mammalian cells in culture. The infusion of insulin alone (in the presence of elevated glucose levels) or together with glucose significantly suppressed the IR-GIP rise after fat ingestion, but it did not alter the GIP response to oral glucose. The islets of animals older than 40 weeks, however, were characterized by greater insulin content, and a restored typical biphasic insulin secretion profile.

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74, 941-945) in that they are much less polar than the parent steroid and yield the parent steroid as a product of treatment with alkali. A number of techniques have been developed to perform gene expression profiling. Seventy-four per cent of identical bacterial isolates were found in the pharynx of the same animal.

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Pirenzepine did not depress the forelimb vasoconstriction and the cardioacceleration evoked by electrical stimulation of the postganglionic vertebral and inferior cardiac nerves, respectively, suggesting that PZP does not act at the neuro-effector junctions. New onset contralateral vesicoureteral reflux developed in a third of the patients initially diagnosed with unilateral disease while they were followed nonoperatively.

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Cloning and expression of a cDNA encoding the homologue of Ran/TC4 GTP-binding protein from Plasmodium falciparum. This study was designed to investigate the effect of intermittent calf compression on popliteal arterial blood flow and to see how flow is influenced by position of the subject and by arterial blood pressure at the ankle. The absorbance of the stained bacteria on the slide was measured in a spectrophotometer at 590 nm.

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Inappropriate left ventricular mass is associated with microalbuminuria independently of left ventricular hypertrophy in primary hypertension. Bleomycin pharmacology in relation to adverse effects and renal function in cervical cancer patients. A diagnostic stellate ganglion block provided complete relief for two weeks.

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Of a number of factors involved in apoptosis, protease activity may play a crucial role. Subretinal and retinal deposits, including deposits in the pigment epithelium. Polymorphism in the LMP2 gene influences the relative risk for acute anterior uveitis in unselected patients with ankylosing spondylitis.

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The correlations of the exponent of the power function between visits were high and stable. In all these studies the mean levels observed in patients with AS were similar to those in 31 normal subjects. We report here that neutrophils are the first nucleated mammalian cell type demonstrated to be devoid of immunoreactive PARP. A comparison of the new fluctuating charge model with an established fixed charge model reveals some differences that may be critical for the correct prediction of the infrared spectrum and energy barriers.

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The use of community health workers has been successful in some urban settings. Two monoclonal antibodies, AMH-2 and AMH-3, reactive with alveolar macrophages and epithelioid cell granulomas Specific-pathogen-free (SPF) chickens inoculated with low passage Chicken anaemia virus (CAV), SMSC-1 and 3-1 isolates produced lesions suggestive of CAV infection. Of 4 neurons that showed the antidromic response to the accessory celiac vagus, 1 neuron increased and 1 neuron decreased their discharge rates in response to topical administration of glucose. Integrating patient satisfaction with a quality improvement program.

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The objectives of this study were 1) to investigate the incidence of ALD in Japan from 1998 to 2002, and 2) to determine whether hepatitis virus affects its prevalence. Nineteen blind eyes enucleated for painful angle closure-glaucoma secondary to iris neovascularization (rubeosis iridis) were examined by scanning electron microscopy and correlative light and transmission electron microscopy. We have previously provided indirect evidence for endothelial cell activation and a proinflammatory cytokine response. In the ORN cohort, the percentage of nephrectomies performed on small tumors (less than 4 cm) has decreased with time, and the trends in the OPN group have remained relatively stable. Multiple nucleotide substitutions that did not change size polymorphisms were observed in all three markers.

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Therefore, we investigated the temporal and spatial distribution of four major variants of the p63 transcription factor-TAp63alpha, TAp63gamma, DeltaNp63alpha and DeltaNp63gamma-during normal skin wound healing in mice. Variability of drug response is also a consequence of a variety of drug interactions which may influence pharmacokinetic parameters. Recently, it has been reported that the pathway activation is resulted from aberrant expression of the ligand, Sonic Hh (Shh), in pancreatic cancer and breast cancer. The quality and stability of essential drugs in rural Zimbabwe: controlled longitudinal study. Oral amoxicillin with gentamicin has been used to treat enterococcal endocarditis.

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Compounds 1 and 2 exhibited significant levels of cytotoxicity against three human cancer cell lines, and these two compounds also induced apoptosis in the same cell lines, as evidenced by changes in the morphological features of cells treated with these compounds and their dose-dependent accumulation of a sub-G1 population. Extraction of methylmercury from tissue and plant samples by acid leaching. We compared their symptom scores and serologic changes with two control groups of SRW-sensitive patients.

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At 2 hours post injectionem there was a preferential localization over interfaces between lymphocytes and dendritic reticulum cells. Further comparisons between the deletions present in the patients and their clinical features identified several chromosomal regions that were involved in specific clinical features. Appreciation of such a relationship is needed when setting realistic treatment goals according to an absolute risk standard, particularly in the elderly. Principles of protein folding--a perspective from simple exact models. RNA was extracted from skin biopsy specimens of 6 patients with AD and 7 patients with psoriasis and analyzed with the use of Hu-U95Av.GeneChip microarrays.

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Infection of the trophoblasts resulted in the expression of pro-inflammatory cytokines in a dose-dependent manner similar to that observed with C. Differences in gene expression in the mouse frontal cortex were studied using a whole-genome microarray approach. It can be the basis of development of embedded parameters measurement system and can provide accurate feedback information for intellectual electrosurgery.

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Polyamine metabolism in reversible cerebral ischemia of Mongolian gerbils. Intralesional surgery of primary tumors of the anterior cervical column. An experience with 64 operations for aortic coarctation is summarized. Mannitol was found to inhibit NA,K-ATPase when compared with mannitol-free medium (11 U vs.

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Prostacyclin and thromboxane A2 in preeclamptic umbilical circulation. With an aging and diminished work force, nursing leaders must be prepared to create a caring environment where nurses are empowered to deliver the humanitarian as well as technological aspects of caring. Strategies to incorporate left atrial appendage occlusion into clinical practice. Regional cerebral blood flow was measured using the H2 clearance method bilaterally in the middle cerebral artery territory.

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In this study, we report that alternative splicing of exon 4 resulted in two transcripts, Osr2A and Osr2B. Effect of ring fusion on the electronic absorption and emission properties of oligothiophenes. Both ketoprofen and lysine acetylsalicylate proved significantly more effective than placebo, with no apparent difference between them. Approach to the classification of diseases of the temporomandibular joint Kinetic study of antitumor lymphocyte cytotoxicity in rats bearing progressive or regressive syngeneic colonic tumors

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With a degree of training, any of the three instruments could be used to assess psychosocial adjustment with some measure of confidence in the validity of the rating. The concentration of putrescine and spermidine in cell-free ascites fluid and serum was found to increase significantly with increasing tumour mass.

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Rabbit anti-idiotypic sera were prepared against Semliki Forest virus (SFV) neutralizing monoclonal antibody (MAb) UM 1.13 and mumps virus neutralizing MAb UM 10B. Simultaneous quantitation of five Panax notoginseng saponins by multi heart-cutting two-dimensional liquid chromatography: Method development and application to the quality control of eight Notoginseng containing Chinese patent medicines. With such a prospect for quality control and establishment of a protocol of individualization of treatment, we have a right to expect that appropriate surgical and radiotherapeutic measures will gain their proper priority and adjuvant hormonal therapy and chemotherapy may be incorporated.

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The assumption that the smile is an evolved facial display suggests that there may be universal features of smiling in addition to the basic facial configuration. After 1 wk in culture, 48 of 50 synaptic boutons contained predominantly dense-cored vesicles, but by 8 wk the synaptic vesicle population was predominantly of the clear type. Radiotherapy-induced plasticity of prostate cancer mobilizes stem-like non-adherent, Erk signaling-dependent cells. The incidence of perioperative myocardial infarction, renal failure, neurological sequelae, leg infections, or thromboembolic events was similar in diabetic and nondiabetic patients. The effect of previous surgery, operating room environment, and preventive antibiotics on postoperative infection following total hip arthroplasty.

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Small defects following intraoral resection are often resurfaced by skin grafts. Lower concentrations of TGF-beta 1 demonstrated no significant differences from control. Prognostic value of beta-2-microglobulin in Hodgkin disease in young adults

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Down-regulation of steroidogenic cytochrome P450XVII in cryptorchid rat testes. Main principles of a computerized data collection system of the objective neurologic finding are presented. In contrast, we have previously shown that IFN-gamma requires 72 h to render HEC susceptible to lysis with acute KS sera. Prostaglandin synthesis by lymphoid tissue of mice experiencing a graft-versus-host reaction: relationship to immunosuppression. Radiologic consultation: its application to an acute care surgical ward.

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A new modified method of measurement of diphenylhydantoin and phenobarbital in serum by high pressure liquid chromatography. A study on the clustering technology of underwater isomorphic sensor networks based on energy balance. Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis. AG induced the production of intracellular, membrane-associated, and secreted forms of interleukin 1 (IL1) in a dose-dependent manner, with 50 micrograms/ml yielding maximal responses. A correlation of the EEG, the clinical picture and action of the central adreno- and cholinolytics and adrenomimetics demonstrated that in acute influences on the stem it is always in an irritative state.

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No effects were found regarding smoking cessation, physical activity, anxiety and depression. A class switching approach was used in Fd and light chain gene assembly.

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It was found imperative to have an initial 30 min rest period, after venipuncture, to obtain a stable baseline in the fibrinolytic studies. Histopathology served as reference in all patients, and in further 60 patients, a benign lesion was verified at follow-up (mean follow-up of 1,040 days).

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Self-filling blind loops were created experimentally in jejunal segments of specific pathogen-free male Wistar rats, and the loop contents and mucosa were examined over an 8-week period for evaluation of the interaction between mucus and luminal bacteria. Long noncoding RNAs (lncRNAs) are dysregulated in many cancer types and are believed to play crucial roles in regulating several hallmarks of cancer biology. The amount and structure of dental deposits formed on plastic films were determined at two occasions with or without a preceding period of effective oral hygiene. Because helium-oxygen therapy can reduce stridor scores and is clinically preferred by physicians caring for stridorous children, it may be a useful adjunctive therapy in pediatric trauma patients with postextubation stridor. Treatment with DTC induced distinct changes in the percentage of cells expressing specific surface antigens that differed between the NZB/W and the Balb/c.

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Based on the similarities of the clinical picture of the Greek and Hungarian cases, the similar morphology of the Greek and Hungarian isolates, and the identical sequences of the cytochrome oxidase gene of the filarial parasites and that of the 16S ribosomal RNA gene from their Wolbachia endosymbionts, the Onchocerca sp. The patient had undergone a Polya gastrectomy eight years previously. Longitudinal Analysis of the Absence of Intraoperative Neural Response Telemetry in Children using Cochlear Implants. Daily doses of 75 or 150 mg of venlafaxine extended release were administered orally for 24 weeks.

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With significant potential as a robust source to produce specific somatic cells for regenerative medicine, stem cells have attracted increasing attention from both academia and government. This comprises: 1) individual suspensions from samples taken from different areas of the same thymoma, and 2) a pool of these suspensions.