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The drug therapy prescribed for a group of 50 patients with rheumatoid arthritis in Otago prior to specialist referral was examined. A more or less continuous spectrum of number and degree of atypias in megakaryocytes was found.

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A role for D1-D2-G-X3 in homologous recombination repair (HRR) is supported by our finding that FANCG and the RAD51-paralog XRCC3 are epistatic for sensitivity to DNA crosslinking compounds in DT40 chicken cells. This simple in vitro system is now being used to classify newer antitumour agents. Structural biology experiments and structure prediction tools have provided many high-resolution three-dimensional structures of nucleic acids.

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For a drug undergoing tissue elimination such as remifentanil, venous rather than arterial concentrations will reflect more exactly the effect compartment concentrations, under steady-state conditions. To address this issue, we performed a systematic analysis of fusion protein transcriptional targets.

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Moreover, the formation of the complex between IclR and the operator/promoter region has been found to be impaired by phosphoenol pyruvate but insensitive to acetate, acetyl-CoA, pyruvate, and oxaloacetate. A computer method has been developed to determine the relative initial uptake and segmental washout rates of thallium-201 from sequential myocardial images. A series of thienopyridinone derivatives was designed and synthesized as inhibitors of checkpoint kinase 1 (Chk1). Effects of factor Xa on the expression of proteins in femoral arteries from type 2 diabetic patients. Adverse effect of estradiol when used for hormonal pregnancy diagnosis in swine

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Although quantitative characterization of growth phenotypes is of key importance for the understanding of essential networks driving plant growth, the majority of growth-related genes are still being identified based on qualitative visual observations and/or single-endpoint quantitative measurements. The carbon sources decreased in effectiveness (as determined by generation times) in the following order: sucrose, acetate, glycerol, and ethanol. Tail-flick latencies were assessed at 0, 30, 60, 90 and 120 min after injections by measuring the time that it took each rat to remove its tail from a 52 degrees C water bath. Since there is little doubt that the cancer-induced platelet alterations are beneficial to tumor growth and dissemination, it could be worthwhile to intervene in the underlying mechanisms for anticancer purposes.

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Interferon beta 1b (Betaferon) and 1a (Avonex) were licensed in Italy for treating relapsing-remitting multiple sclerosis in February 1996 and August 1997, respectively. Interactions involved in the binding of the anthracycline analogues adriamycin, carminomycin, pyrromycin, musettamycin, marcellomycin, and aclacinomycin to calf thymus DNA and covalently closed circular PM-2 DNA have been studied. New archaebacterial genes coding for redox proteins: implications for the evolution of aerobic metabolism. The 2 primary RCC cell cultures and the 2 cell lines examined expressed varying basal levels of ICAM-1 on the cell surface.

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Missing emergency department charges were estimated by multiple imputation. Patients with recently acquired TBI are impaired in their ability to perceive emotions in faces. The ability to control osmotic balance is essential for cellular life.

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Resistance of the auditory brain stem response to high barbiturate levels. Diurnal and seasonal variations in activity of crassulacean acid metabolism and plant water status in a northern latitude population of Opuntia erinacea. Spontaneous respiration via a face mask did not lead to significant hypercarbia, acidosis or cardiac arrhythmia. We established a simple and defined method to detect the mutant SODI in erythrocytes by electrospray ionization mass spectrometry (ESIMS) using materials precipitated with specific antiserum.

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A systematic review of home treatment services--classification and sustainability. Salivary glucose clearance, dry mouth and pH changes in dental plaque in man. Application to Escherichia coli and Bacillus subtilis acetylvalyl-tRNA covalently linked to E.

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Enhancement of polyoma virus middle T antigen tyrosine phosphorylation by epidermal growth factor. The TCT-treated patients reported more satisfaction with the training than the yoga group. Surgical specimen of the esophagus and the aorta showed a fistulous tract extending from an esophageal tumoral mass to the aorta. miRNAs are highly homologous, conserved and are found in various living organisms including plants and animals. The mouse mutant mocha, a model for the Hermansky-Pudlak storage pool deficiency syndrome, is characterized by defective platelets, coat and eye color dilution, lysosomal abnormalities, inner ear degeneration, and neurological deficits.

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Functional diagnosis of coronary stenosis using tissue tracking provides best sensitivity and specificity for left circumflex disease: experience from the MYDISE (myocardial Doppler in stress echocardiography) study. Collectively, our findings reveal a novel mechanism potentially responsible for the dynamic programming of innate immunity in vivo as it relates to sepsis risks. In contrast, induction of diabetes mellitus in LE rats, which resulted in a marked polydipsia and polyuria even though vasopressin was still present, did not impair the drinking response to quinine solutions.

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Interleukin 2 receptors on an insulin-specific T cell line: dynamics of receptor expression. The human oxoguanine glycosylase 1 (hOGG1) gene encodes a DNA glycosylase that is involved in excision repair of 8-OH-dG (8-hydroxy-2-deoxyguanine) from oxidatively damaged DNA.

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Further research is required to explore the possibility that mutation results in a gain of Nrg1 function. A three-year study of a first-generation chemotherapy-compounding robot. The telegenetics model created was based on development and implementation of a preventive and medical management technology solution, conducting a pilot study to collect data, and approaching insurance companies for reimbursement. qRT-PCR analysis was used to compare the expression patterns of osteoblastic markers in transfected cells.

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Mediastinal injuries require the use of the heart-lung-machine, if the heart and the big vessels are involved. The results indicated that the 5-HT concentration was reduced in platelets and 5-HIAA excretion in urine was below normal levels. The present report illustrates the experience at one center where the work has been carried out for a number of years. The author developed a special method for the mobilisation of the small intestine and the right colon for the transposition in the thoracic cavity. Our results suggest that augmentation of growth by low concentrations cannot be explained by inhibition of PGE2 production alone.

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However, the message regarding the substantive and unique contributions of this body of work needs to be disseminated more broadly. The life span of RBCs may be shortened in patients with CDA-II, a phenomenon that has been ascribed to this membrane defect.

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Treponema phagedenis could be differentiated from all the other spirochaetes by the production of alpha-fucosidase. However, l-isomer was more potent than d-isomer in suppressing these responses.

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Data bank searches revealed high sequence similarity of the protein (55.11) to yeast, nematode and plant proteins, whose functions are yet unknown. The pargyline-induced depletions of DOPAC in the caudate putamen and amygdala were significantly greater in rats that performed operant behavior than in control rats. We identified early proapoptotic transcriptional changes, including upregulation of proapoptotic Bax and downregulation of antiapoptotic Bcl-xL, Bcl-2, and Bcl-w, using Affymetrix DNA microarrays. Surgical treatment of idiopathic thoracolumbar scoliosis: Contrell-Dubousset instrumentation versus ventral derotation spondylodesis In male patients the percentage of OKT8 was significantly reduced, the percentage of OKT4 was significantly increased, and the ratio of OKT4/T8 was increased.

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The tendency to a corticosterone rise after repeated treatment with diazepam, 10 mg/kg, coincided with the enhanced weights of adrenal glands in these animals. The imperfection will appear according to the predominance of one or the other, or both, and the contracture of the two muscular portions.

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EcxR also activated transcription of all five virBD loci in lacZ reporter constructs. Influence of Intralipid on the properties of circulating phagocytes

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Based on molecular interactions of the Min system, we formulated a mathematical model that reproduces Min patterning during cell growth and division. No significant difference in the latency-intensity function was obtained for the click between the quiet and the low pass noise conditions. Ia glycoproteins have been isolated from human chronic lymphocytic leukemic cells (CLL) by Lens culinaris chromatography and by filtration on ACA-34 Ultrogel.

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Particularly the following points have been dealt with: comparison of different methods for the assessment of psychotropic effects, special problems of rating scales, studies on the AMP-system concerning psychopathological and methodical aspects, conversion and processing of AMP-data, general considerations on the statistical analysis of drug trials. Using specific antibodies raised against gH2B and gH3, we examined in detail the temporal and spatial aspects of the appearance of these histone variants during male gametogenesis. In 25 (46 per cent) of these procedures the cultures were positive. The metabolites were characterized by gas chromatography/electron impact mass spectrometry as methyl and/or trifluoroacetyl derivatives.

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The 5 year follow-up of 20 children suffering from cerebral palsy who had undergone early surgical release procedures for deformities of the hand has indicated certain positive advantages for this method of treatment. The use of two Hulka-Clemens spring clips on each Fallopian tube has been recommended to reduce the risk of sterilisation failure due to clip faults. Differential regulation of interleukin 1 receptor and Toll-like receptor signaling by MEKK3.

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This corresponded to the time of synthesis of mRNA that stimulated the maximum rate of ASSP synthesis in vitro. Correlation between oral hygiene habits and dental caries levels in Brac schoolchildren The quantative measurement of cytocidal actions of antimetabolites, Vinca alcaloids and L-asparaginase against in vitro cultured Yoshida ascites sarcoma cells Results showed that MMC (1-10 mumol/L), CP (0.316-3.16mmol/L), and DDP(3.16-31.6mumol/L) resulted in a significant induction of dose-dependent UDS and that DAT (0.5-4.0 mumol/L) significantly enhanced induction of UDS by MMC, CP and DDP while DAT itself did not.

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Contact hypersensitivity to dinitrochlorobenzene (DNCB), picryl chloride (PCl) or oxazolone was induced in mice by skin painting with these agents, and was measured by skin testing in vivo using the ear swelling method. Therefore, the immunoblotting with this antibody may be useful as a sensitive assay for detecting the action of neutrophil proteases on red blood cells. Apolipoprotein E and amyloid P component colocalized with the 3 amyloids. A new small caliber single-lumen balloon catheter has been devised specifically for retrograde ureterography.

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Mean phase shift duration and phase locking intervals were computed for two symmetrical electrode arrays in the posterior-to-anterior locations and the anterior-to-posterior directions in the alpha frequency band (8-13 Hz). This may decrease the number of complications occurring when excessive cryotherapy or laser photoablation must be used in zone 1 ROP. Twenty-one patients had anomalies of the facies and brain stem dysfunctions.

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In our study, we investigated the mechanism leading to apoptosis in HT-29 cells in response to TNF-alpha and ligation of Fas Ag. Using nanoparticle delivery for anticancer therapy is a potential new drug modality.

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A microneutralization test for the assay of porcine parvovirus antibody. In this patient we found a single tumor cell line within the normal lacrimal gland. This study shows that NGS can be used for extensive assessment of genetic mutations involved in antifungal resistance. Len c 1, a major allergen and vicilin from lentil seeds: protein isolation and cDNA cloning.

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This enhancement in platelet reactivity may be associated with cardiovascular morbidity in the withdrawal state of alcohol dependency. The molecular pathology of chronic nitrate intoxication in domestic animals: a hypothesis.

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Foaming activity required both hydrophobicity and other factors pertaining to the adsorption of proteins at the interface in order to obtain adequate foam lamella strength. Heat treatment of extract and G 50 separated fraction P2 demonstrated total loss of hypoglycaemic activity. The Clinic has a psychoanalytical orientation and has a strong tradition in group psychotherapy, family therapy and social therapy. The optimal cultivation parameters, such as the initial glycerol concentrations in the two chambers, the desired transport rate across the membrane, glycerol concentration in the feed/dialysing medium, and the time to start the medium exchange, were determined from preliminary experiments and calculations.

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The kinetics of the oral absorption of alcohol and the relationship among stomach emptying rate, the apparent absorption rate, and the area under the BAC-time curve are discussed and data presented. A comparison was made between the rate of iodide permeation of dentin by diffusion and by filtration. A survey carried out by the Institute for Consumer Ergonomics in Loughborough. These results are consistent with epidemiologic evidence suggesting that high density lipoprotein cholesterol concentration is inversely related to probability of developing clinically manifest atherosclerotic disease.

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A simple 5-item risk index based on readily available clinical data accurately stratifies average-risk patients into low- and intermediate/high-risk categories for ACN at screening colonoscopy. The major allergens of all species belong to the pectate lyase enzyme family.

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Chondrogenic differentiation of human adipose-derived stem cells: a new path in articular cartilage defect management? L-IRMA may therefore be a simple method to study the glycoprotein heterogeneities in tumors and in normal subjects. It is equally doubtful that the production and/or presence of these toxins confers a selective advantage on the phytoplankton producers, when in fact the diversity of naturally occurring phytoplankton species may well be maintained by lytic viral infections (22,64). Distinctive and common neural underpinnings of major depression, social anxiety, and their comorbidity.

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Carotid pseudoaneurysm after laryngectomy is a very uncommon complication. Interferon-gamma induces characteristics of central sensitization in spinal dorsal horn neurons in vitro. Multifocal epileptogenic effects of the cortical topical use of cobalt powder

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Production of interferon and other lymphokines during murine tumour growth. We have used a GFP-based assay for chromosome loss in human cells to investigate the effects of over-expressing Securin.

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Regular assessments are especially important in children subjected to long-term systemic steroid treatments. Surgical reconstruction in the second stage after burn injury requires an individual approach. Fatal amiodarone-induced hepatotoxicity: a case report and literature review.

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EspA, EspB, intimin, Tir, and bundle-forming pilus expression is detectable during the entire 5-h infection. Some investigations concerning the problem of front-back discrimination in normal hearing are described.