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Complete radiologic response in metastatic castration-resistant prostate cancer treated with cabazitaxel. Use of a size 2 LMA to relieve life-threatening hypoxia in an adult with quinsy. In the present paper a selection of the most important patent applications published within the last 3 years and claiming the use of homologous cellular and extracellular agents as therapeutics or targets to prevent restenosis are reviewed. The study comprised a retrospective interrupted time series analysis, comparing rates of malaria diagnosis, treatment, and resource utilization before and after introduction of RDTs at a peripheral health facility in rural Western Uganda. These observations provide confirmatory evidence of a post beta-adrenoceptor blockade withdrawal syndrome which differs between the two drugs studied and this may reflect the properties of the drugs, in particular the PAA of bopindolol.

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Thus, this decamer sequence represented the optimal Ig-SAg epitope or mimotope. Patients with impaired ankle function, as shown by means of an ankle score at 12 months, were followed for 3 years. No significant difference was demonstrated between platelet lifespan in pregnant women (9.2 days), in non-pregnant women (9.7 days) and in men (9.2 days). Calcium and phosphorus metabolism in stable renal transplant recipients. Both highly endotheliotropic and poorly endotheliotropic virus clones, representing three distinct restriction fragment patterns, were reconstituted after transfection of BAC clones derived from previously plaque-purified strain TB40/E.

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There is now good evidence to support the idea that melodic contour and tone chroma, in addition to tone height, contribute to recognition of both highly familiar and recently learned melodies. It is postulated that those antibodies demonstrable by the ordinary IgG indirect method and those antibodies possessing capacity to fix complement should bind to different sites of the basement membrane zone. Between September 1987 and December 1992, 52 hospitals had consultation visits using American College of Surgeons criteria. Each imaging plane, including the transverse, oblique coronal, oblique sagittal, and oblique transverse in abductor external rotation (ABER) position were evaluated for the following three findings: tear of the superior labrum at biceps tendon insertion, Bankart lesion, and continuity of the two former findings.

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In 3-D, responses were sampled with 12 x 12 x 10 resolution in spatial frequency, orientation, and temporal frequency. Only active enzyme variants can hydrolyse toxic halogenated alkanes to promote growth, whereas inactive mutants starve or die due to the toxic compound. Composition of cardioplegic solutions used in nine medical centers. Forms of organization for the coordination of health services in socialist countries All available data, however, suggest that the 2-kilobase spacing of BamHI sites within the repeat may be specific to the X chromosome.

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The concentration of insulin that produces half-maximal stimulation of glycolysis by stripped soleus muscle preparations is markedly increased by the adenosine analogues, 2-chloroadenosine and N6-phenylisopropyladenosine, but is markedly decreased by the methyl xanthine analogue, 8-phenyltheophylline. In conclusion, outstretching the arms helps postural stability in challenging situations such as tandem stance on a narrow beam with eyes closed. Muscular tumors as a cause of recurring intestinal hemorrhage (apropos of 3 cases) Can gamma-glutamyl transferase levels contribute to a better prognosis for patients with hepatocellular carcinoma? Characterization of intracranial neoplasms by CT and intraoperative sonography.

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Central AVP may play a role in enhancing, while serotonin plays a role in inhibiting, aggressive behavior in personality-disordered individuals. The comparison also confirmed a favorable effect of spinal cord stimulation on the development of bladder automatism. Pharmacologic interventions are usually necessary for agitation, physical attacks, and significant delusions or hallucinations. MicroRNAs (miRNAs), a class of small RNAs, have been intensely investigated recently because of their important regulatory role in gene expression. Childhood cancer: basic considerations in diagnosis and treatment.

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Cytoskeletal organization of the vestibular sensory epithelia: saponin perfusion method for observing intracellular structures by scanning electron microscopy. Twenty adult males and postmenopausal females with MetS and symptoms suggestive of OSA were enrolled in the study.

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The insulinomimetic agents H2O2 and vanadate stimulate tyrosine phosphorylation of potential target proteins for the insulin receptor kinase in intact cells. These abnormal dendritic patterns show a striking resemblance to those described by Purpura in mentally retarded children of normal karyotype. These approaches permit similar inferences about whether the association is due to individual (fetal) or shared (maternal) factors, and are valid in the circumstances that non-shared factors missing from the regression model do not influence the regression estimates.

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Stress-induced reversible and mild-to-moderate irreversible thallium defects: are they equally accurate for predicting recovery of regional left ventricular function after revascularization? Bladder urothelial cells (BUCs) from patients with interstitial cystitis (IC) patients have augmented release of ATP during in vitro stretch.

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The overall expression of Fas receptor, found on cultured NP cells, could have disadvantageous implications on their potential therapeutic applications because they could be the targets of cytotoxic T-cell activity acting by Fas ligand-induced apoptosis. Propranolol did not influence the responses of the intestinal circulation to adenosine suggesting that beta-adrenergic receptors are not involved in the action of adenosine. There is a good disposition to volunteer their work and skills, recognizing it as a moral/ethical/professional obligation. The optimal pH for renin activation by the membrane was pH 5.0 to 6.0. Pretreatment with the 5-HT1A receptor agonists 8-OH-DPAT or gepirone does not attenuate the inhibitory effect of systemically administered cholecystokinin (CCK) on food intake in rats.

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Compressive myelopathy associated with type VI mucopolysaccharidosis (Maroteaux-Lamy syndrome). Exon 5, in particular, has an unusual structure such that a polypeptide product is unlikely to be anchored in the cell membrane. To determine whether these processes are dependent upon the same or different populations of stromal cells, stromal cell lines were generated from the adherent layer of a Dexter type long-term bone marrow culture.

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The feasibility of selectively eliminating human antigen-specific B cell responses by treating cells in vitro with antigen covalently linked to a cell toxin was examined. With mouse Mb, the autoimmune T-lymphocyte response was under genetic control and mapped with the I-A and the H-2D end of the H-2 gene complex. The relationship between bronchial elastic sign and peripheral bronchogenic carcinoma: a preliminary report

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We identified 30 trials with a total of 4344 participants randomised, with 17 different drugs or treatment comparisons. In two cases, the MR changes were subjacent to the scalp areas where the most severe cutaneous lesions were located in the neonatal period. This forum article features the current knowledge on the role of GSH in redox signaling, particularly the regulation of transcription factors and downstream signaling in lung inflammation. The variant line has been shown to synthesize and secrete increased levels of heavy chain, light chain, and J chain polypeptide compared to the parental wild-type cells from which it was isolated.

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Here, we report that Grp78 heterozygosity has no effect on organ development or antibody production but prolongs the latency period and significantly impedes tumor growth. A method is suggested for the interactive input, conversion and presentation of data about the structure of irradiated organism preset as Data Reference Planes (DRP). This heptameric isoform can accommodate double-stranded DNA in its central channel, which nicely explains its recently described DNA remodeling activity. Nocturnal and day panickers differed in their responses to the hypnosis scene only.

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Effects of the dipyridamol-dihydroergotoxine methane sulphonate associations on pO2 and its incidence in brain tissue. After no mites were seen, treatment was continued for at least 2 more weeks and then stopped. Histochemical studies have revealed hydrolytic enzyme activity in the redial tegument and caecal epithelium of Fasciola hepatica.

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In a dual-task paradigm participants had to execute bimanual pointing movements to different peripheral locations, and to identify target letters that had been briefly presented at various peripheral locations during the latency period before movement initialisation. From a theoretical point of view, a clinical relevant interaction may exist between clopidogrel and cytochrome P450 3A4 metabolized statins.

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Activins have potent effects on early morphogenetic events during amphibian embryogenesis but no evidence for their role during human development other than their expression in steroidogenic tissues has been reported. In order that tmRNA could participate in the ribosomal elongation cycle, a triplet preceding the mRNA portion of tmRNA (the -1triplet) should be in the A-form and this form should be recognized by the ribosomal decoding center. All the mutants except bel4 also showed high levels of transcription of an intact PHO5 DNA integrated at the URA3 locus in the absence of the cognate transcriptional activator, Pho4p, and in the absence of upstream activating sequences of PHO5.

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Neutron doses of 0.02 Sv were measured in correspondence to the cervix, 50 cm from the photon beam axis, following a complete treatment course of 46.5 Gy with an upper mantle field of 18-MV x-rays. Thorough investigation into the circumstances surrounding these four incidents, along with the evaluation of the forces exerted upon the cranium at the time of impact, suggest that symmetrical cranial fractures in infants are most likely the result of bilateral compression of the head between two surfaces, rather than the result of a localized impact. Of the 23 studies identified, 10 focused on hypertension, seven on diabetes, one on dyslipidaemia, one on coronary heart disease, one on heart failure and three covered multiple diseases. A high index of suspicion must be maintained for all dimples above the intergluteal fold despite a normal examination or neuroradiologic studies. Oxygen sites in the zeolite stilbite: a comparison of static, MAS, VAS, DAS and triple quantum MAS NMR techniques.

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It may be used either as a bridge to cardiac transplantation or as a destination therapy. Ocular findings in patients with autosomal dominant retinitis pigmentosa and transversion mutation in codon 244 (Asn244Lys) of the peripherin/RDS gene. 8-Methoxypsoralen (1 microgram mL-1, 4.6 microM) added to (phytohaemagglutinin-stimulated cells induced a two-fold increase in the number of mitoses. Lymphocyte numbers and function in 37 patients with colorectal cancer were compared with those in 23 healthy controls of the same age range.

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Treatment with hyaluronate increased the rate of cell seeding to 2.04 times that of untreated control cultures and 1.82 times that of chondroitin sulfate-treated cultures. 34 polycythemic patients, in complete or partial stable remission, were studied for beta-thromboglobulin (beta-TG) and platelet factor 4 (PF-4) before, during and after treatment by an antiaggregating agent, ticlopidine, in comparison with 30 untreated patients. The solubilized enzyme has been enriched by precipitation with polyethylene glycol and chromatography on DEAE-Sephacel and hydroxylapatite columns. Lipids of myelin, white matter and gray matter in a case of generalized deficiency of cytochrome b5 reductase in congenital methemoglobinemia with mental retardation. Models of these phenomena have thus used additional concepts, for example, appealing to attentional effects or more elaborate learning mechanisms.

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Nurses in practice collaborate in teaching clinical nursing research. Tissue-type plasminogen activator (t-PA) is a serine protease with a molecular weight of about 70,000.

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Mortality was analysed based on signal profiling, and appropriate statistics were used. The effect of irradiation on the tumor histology was severely expressed in the nucleus and cytoplasm on the 4th to 7th day. Co-ordinate regulation of the biosynthesis of the majority of constituent proteins. Building on a clear understanding of the purpose and dimensions of population health that must be measured, developers can then choose specific measures using existing data or developing new data sources if necessary, with established validity, reliability, and other scientific characteristics. In this paper, we study heteroclinic bifurcations of such a predator-prey model.

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Relationship between expression of 5-fluorouracil metabolic enzymes and 5-fluorouracil sensitivity in esophageal carcinoma cell lines. Other therapeutic nucleic acid materials such as small interfering RNA, antisense oligonucleotides, or microRNA have also been included into the protocols of gene therapy. Genetic toxicological of some plant flavonoids by the micronucleus test. Furthermore, the 125I-labeled cytotoxic eluates recognize the same determinant(s) on IgM and IgG.

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The labeled cells were analysed with a flow cytometer, equipped with an argon-ion laser and a (0.5 mW) helium-neon laser. 1) disc disease: 11 cases, 2) spinal cord tumor: 6 cases, 3) Arnold-Chiari malformation: 3 cases, 4) atlantoaxial dislocation: 3 cases, 5) ossification of the posterior longitudinal ligament (associated with ossification of the ligamentum flavum): 2 cases (1 case), 6) spinal foreign body (acupuncture needle): 1 case. Purification of 20 alpha-hydroxysteroid dehydrogenase from human erythrocytes. Epidemiologic studies suggest that statin use may be inversely associated with risk of prostate cancer, but prior studies have focused predominantly on non-Hispanic white populations.

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Influence of climatic conditions on the mutations in pollen mother cells of Tradescantia clone 4430 and implications for the Trad-MCN bioassay protocol. Growth kinetic measurements reveal an almost complete mitotic block 6 h after exposure, followed by a large overshoot in cell proliferative activity. In functional studies, inhibition of Src-kinase activity with PP2 partially reversed actin disintegration and also restored amylase secretion. In our current communication, we outline the indications and the surgical technique of hemispherotomy and report our experience of the clinical application of this surgical procedure. Cytochemical characteristics of leukopoietic differentiation in murine erythroleukemic (Friend) cells.

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MCD spectra of iron-sulfur complexes with or without inorganic sulfur. We designed to determine the CGRP-I (or CALCA), II (or CALCB) gene expression and morbidity and CALCA T-692C single-nucleotide polymorphism (SNP). The genus Paralia Heiberg is one of the most recognizable, widely distributed and commonly reported diatoms from contemporary coastal marine environments and ship ballast. These functional changes all contribute to the development of ISH in elderly persons. The possibility was examined that changes in sensitivity of the aorta to alpha-adrenoceptor agonists during pregnancy in the rat are due to changes in smooth muscle receptor-mediated responses and/or endothelial cell-mediated responses.

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Electronic databases are not sufficiently up to date to provide comprehensive notation of the most recent literature for reference in developing scientific papers. We consider three penalty functions, least absolute shrinkage and selection operator (LASSO), smoothly clipped absolute deviation (SCAD) and HL, in our variable selection procedure.

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RA-induced Runx2 in lower sternal chondrocyte cultures and over-expression of wild-type (WT) Runx2 enhanced colX and alkaline phosphatase activity, while over-expression of dominant negative Runx2 was inhibitory. Equivalent oral dosages (800 mg, 21.6 mmol) of standard ( Lithicarb ) and sustained-release ( Priadel ) lithium carbonate preparations were administered using a randomised cross-over design to six patients receiving long-term lithium maintenance and eight healthy student volunteers. Retinal did have an effect on the geometric structure of the liposomes. These results are in agreement with those obtained in rats maintained on a low iodine diet suggesting that high cellular enzymatic activity is due to specific enzyme induction in excess of cell proliferation and protein synthesis.

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Patients with VAD performed worse on tests that are influenced by frontal and subcortical mechanisms. Subsequent univariate analyses revealed, however, differential effects of caroverine--dependent on recording conditions and doses.

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A normal lens phenotype is restored in double transgenic animals that carry both wild-type and mutant human p53 alleles. Eye stabilization by vestibulo-ocular reflex (VOR) and optokinetic reflex (OKR) in macaque monkey: which helps which? The fibrinolytic activity of the endometrium of the two uterine horns in the rat was histochemically determined. A prominent labelled protein of apparent molecular weight of 60 000 is observed in the soluble fraction after neuraminidase treatment of intact cells. Compound 13 g which has a N-sulfonylmethyl substituted imidazoline moiety showed the most potent antibacterial activity.

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Complex evaluation of hemodynamics in the arteries of the extra- and intracranial parts of the brain Transcriptional regulation of phospholamban gene and translational regulation of SERCA2 gene produces coordinate expression of these two sarcoplasmic reticulum proteins during skeletal muscle phenotype switching. In this review, we summarize the salient features of macrophages and DCs in the healthy and inflamed intestine and discuss how signals from the microbiota can influence their function. Effects of human recombinant tumor necrosis factor-alpha and interleukin 1 on the synthesis of glycosaminoglycan and DNA in cultured rat costal chondrocytes. We present the case of a 54-year-old woman affected by a large perineal region eccrine porocarcinoma, with a wide local invasion.

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In patients with cirrhosis, PSE may resolve cytopenia and the clinical complications related to hypersplenism or splenomegaly. Two laboratory based experiments were carried out in which alternative menu interface designs were developed rapidly and compared with the original design. Patients were examined, blood samples were collected, and DNA was isolated. A growing body of evidence supports an active role for enteric glia in neuronal and neuroimmune communication in the GI tract, particularly during inflammation.

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This study investigates the programs offered at Sanhujori centers in order to understand the effects of this new type of health care delivery system on postpartum care. Mexiletine and indoramin did not affect the increases in heart rate produced by stimulation of the cardio-accelerator nerve. The incidence of Pseudomonas aeruginosa bacteremia is increasing. Therefore, it provides a necessary foundation for urban drainage planning and design to accurately assess the capacity of the drainage system and correctly simulate the transport effect of drainage network and the carrying capacity of drainage facilities. A Nitinol sten and a Wallstent were placed into the iliac arteries of 14 sheep (total of 28 stents) and followed angiographically.