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P-glycoprotein is located in tissues with excretory function such as intestine, liver and kidney. Intensive therapy units of five tertiary referral centers in Scotland. Br/Rb ratio obtained by XRF analysis of kidneys of normal and tumor-bearing mice treated with cis-DDP.

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We exemplify these findings by studying strongly interacting bosons in a double well subjected to phase noise. Range of motion and strength of the wrist were reduced on the average of 50 percent.

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Biweekly (once every 2 weeks) heparin-induced extracorporeal low-density lipoprotein (LDL) precipitation (HELP) therapy was evaluated for safety and efficacy in selectively reducing LDL cholesterol levels compared with weekly HELP therapy. Inhibition of apoptosis in cells deficient for Wg signaling only partially rescued the clone growth defect, suggesting that Wg is also required to promote cell proliferation. Ameliorating effects of carnitine and its precursors on alcohol-induced fatty liver.

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Changes in sulphydryl content of the plasma were shown not to be due to weight loss or decrease in plasma protein level. Purification and characterization of an oxygenase component in benzoate 1,2-dioxygenase system from Pseudomonas arvilla C-1. Overexpression of MDM-2 mRNA and mutation of the p53 tumor suppressor gene in bladder carcinoma cell lines. In this study, imidazole, a compound structurally similar to guanidine, was also tested.

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The engorged thoracic rete apparently affects the degree and pattern of thoracic collapse and thereby reduces the amount of displacement stress exerted upon the abdominal organs when the animal is subjected to the high ambient hydrostatic pressures encountered during normal diving. The incidence of paralysis does not correlate with the magnitude of the humoral response to either T. These enriched cells are more responsive to IGFBP-3 and secrete less of this binding protein than non-enriched cells, supporting the concept that IGFBP-3 secretion by human breast cancer cells may function as an autocrine or paracrine modulator of cell proliferation. Brain development in the late gestation in human seems to be equivalent to that in the postnatal stage in rats and mice. Developing and implementing a tool for course evaluation by students.

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A dual effect of corticosterone treatment was observed in the cerebellum during the course of growth. The prospective study included immediate postoperative follow-up data as well as longer term results from the quantitative test series. However there was an early and important drop (p less than 0.001) in blood and liver copper as early as the first month, which continued until the end of the experiment. The phosphoinositide-dependent protein kinase 1 inhibitor, UCN-01, induces fragmentation: possible role of metalloproteinases. Further, gal3 mutation in combination with other genetic defects leads to the non-inducibility of GAL genes.

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Conclusively, the analysis shows that the BMC values lie within normal limits in patients with juvenile periodontitis. Compared to normal subjects, HCA-bearing GSD-Ia patients have a 2.8-fold higher serum IL-8 concentration, while GSD-Ia patients without HCA have a 1.4-fold higher concentration. Physician perceptions of the value of physical modalities in the treatment of musculoskeletal disease. Salient barriers included (1) changing work schedules, (2) poor weather conditions, and (3) lack of scheduled and timely breaks.

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The role of hematopoietic growth factors in lineage commitment and differentiation is unclear. Carraguard use was not associated with abnormal genital findings, other abnormal clinical findings, markers of genital inflammation, epithelial sloughing or microhemorrhage, or self-reported symptoms in women and men, or with abnormal vaginal flora or genital shedding of HIV-1 RNA in women. The current study is the first to suggest an important role in vivo for increased eNOS, and perhaps NO production, in the process of endothelial regeneration and wound repair. Albumin content of airway secretions was higher on the first day but not significantly altered on subsequent days.

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A sensitivity analysis was performed, restricting our evaluation to patients who were adherent to diabetes therapy. The effect of cervical contractions on the generation of intrauterine pressure during the latent phase of labour. Clinical and radiological study of the manubrio-sternal articulation. Alternating hemiplegia of childhood (AHC) is a rare neurological disease characterized by recurrent paroxysmal attacks of hemiplegia.

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It is the application of a combined investigative approach using several different techniques that will further our understanding of new infectious diseases. The prosthesis has been used for the past 3 years, and the last 23 patients are reviewed. Purification and characterization of the nuclease NucM of Erwinia chrysanthemi.

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Visual evoked responses and postmortem findings in a case of cortical blindness. coli within intra-abdominal abscess were observed for most antibiotics with the doses used in this study. Highly enriched pools of UTCs and TGCs were obtained from four bovine placentas (Days 118-130 of gestation) using an optimized fluorescence-activated cell sorting procedure. Addition of FSH in combination with pregnenolone failed to increase progesterone or estradiol levels beyond that seen with pregnenolone alone.

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The growth of PGE1-independent clone 1 was inhibited rather than stimulated by PGE1. This preparation and its complex with aspirin conserves the normal hemostatic system status and moderates the insular system disturbances.

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Purified rat peritoneal mast cells rapidly accumulated 45calcium from the external medium. The reduced cytochrome P-450 donates 2 electrons to dichlorophenolindophenol or to cytochrome c. The authors also analyze a charge structure based upon patient care requirements and apply the budgeting process to the cost determination of nursing services.

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Radioimmunoassay for plasma levels of NPY indicated that the secondary increase of vascular resistance was not associated with a secondary peak in the plasma level of NPY. Therefore we examined whether immersion in a food thickener affects the pharmacological effect in patients taking magnesium oxide tablets, and whether immersion affects its disintegration and solubility. Acceptance of amino acids by transfer RNA in the liver of rabbits in experimental diabetes complicated by glucocorticoid administration Subendomyocardial biopsy was conducted in 18 patients, post-mortem material was studied in 42 cases.

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Myocardial involvement in carrier states for Duchenne muscular dystrophy. Here, we found that consumption of an HFD resulted in neutrophil infiltration and enhanced MPO expression and activity in epididymal white adipose tissue, with an increase in body weight gain and impaired insulin signaling. Additionally, the fact that autoimmune infiltration in GAD65 transgenic NOD mice remained largely restricted to the pancreas, indicates that the organ-specificity of autoimmune disease is dictated by tissue-specific factors in addition to those directing autoantigen expression. In this study, we examined the effects of serotonin (5-HT)3 receptor antagonists (5-HT3RAs) including ramosetron, alosetron, and cilansetron on colonic nociceptive threshold in rats. The aminopeptidase also catalysed the hydrolysis of dipeptides and tripeptides but mostly at rates much less than that with L-lysyl-4-nitroanilide and oligopeptides.

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High-level beta-lactamase-producing mutants had similar degrees of increased resistance, enzyme substrate profiles, and isoelectric (pI) values irrespective of the selective agent. Reconstructing muscle activation during normal walking: a comparison of symbolic and connectionist machine learning techniques.

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Country-specific costs of care from official sources were applied in each analysis. It is well documented that small basic peptides with lipophilic counterparts induce non-cytolytic histamine release particularly from rat peritoneal mast cells, and to a lesser extent from human leukocytes. Rapid diagnosis by demonstration of toxoplasma in the placenta using cell culture The thyroid hormone inhibits the thyrotropin receptor promoter activity: evidence for a short loop regulation. Serum concentrations of transferrin receptor in hereditary hemochromatosis.

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When cells from donors tolerant of H-Y were mixed with cells from donors tolerant of H-2Kb, enhanced mortality among male F1 hosts was again observed. The activity of phosphofructokinase in the perfused rabbit psoas muscle was investigated after perfusion in the presence of either propranolol or isoproterenol, and after 48 hr starvation. Breast pathology findings in the prevention of female cancer in 15,500 women All responded well and there has been no evidence of local disease recurrence in any of the four patients.

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In 11 of 13 eyes injected with methyl methacrylate through the short posterior ciliary arteries, there was a perineural, circular arterial anastomosis (circle of Zinn-Haller) at the scleral level. The populations of Bryansk and Gomel regions (except for a population of Lake Strativa in Starodubskii district, Bryansk region) exhibit broad structural variation, including somatic mosaicism for morphotypes of the salivary gland chromosome set, decondensation of telomeric sites, and the presence of small structural changes, as opposed to populations of Saratov region. The presence of host anti-mIgG antibodies prior to infusion was associated with decreased serum concentrations of T101. Seven patients with Gaucher type 1 disease are presented: five female and two male. The presence of a physician as first responder ensures good quality resuscitation in case of cardiac arrest, and allows recording of a first ECG, which can be very informative, especially in ACS without ST segment elevation.

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Lung and dermal vascular injury produced by preformed immune complexes. The technique is presented here as an alterative method when performing laparoscopic appendectomy. Selenium distribution in blood fractions of New Zealand women taking organic or inorganic selenium.

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Such chronobiologic endpoints are often more sensitive than the mean for separating groups at different risk of developing high blood pressure. Fatty acid metabolism and its longitudinal relationship with the hypothalamic-pituitary-adrenal axis in major depression: Associations with prospective antidepressant response. The internal fixation of prestress type by the Weber technique and the osteosynthesis with Spongiosa-screw are the preponderant methods actually used in surgical treatment.

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Immediate-release morphine was used on an as required basis for incident pain. Levovist improves the diagnostic confidence of duplex scanning, but marginally. Alpl(-/-) mice feature craniofacial shape abnormalities suggestive of limited anterior-posterior growth. The health promotion capacity-building framework is relevant for efforts to build health promotion research into mental health organisations. In mammalian cells, (H37A)M2 forms a high conductance monovalent cation channel that can be blocked by the antiviral drug rimantadine.

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A high frequency of these self-reactive cells are also alloreactive. Delayed-type hypersensitivity (DTH) reaction to SRBC, phagocyte activity and circulating leukocytes also were significantly decreased in mice dosed at 40 and 80 mg/kg ICZ.

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Bilateral lesions of the hypothalamic paraventricular nucleus did not prevent RR-evoked changes. This study demonstrates that NGS of bisulfite treated HPV DNA is a useful and efficient technique to survey methylation patterns in HPV16. The dynamics of apical and basal regeneration were monitored using the monoclonal antibody TS19. The gas-liquid chromatographic retention indices of bile acids with 6 alpha- and 6 beta-hydroxyl groups are compared with those of bile acids without the C-6 hydroxyl group and the effect of the C-6 hydroxyl group on the retention indices of bile acids is determined.

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The scanning protocol generated excellent reproducibility for key bone properties measured at the distal and mid-shaft regions of the 2(nd) metatarsal. Apolipoprotein A5 gene (APOA5) has been shown to modulate plasma triglyceride concentrations.

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The strains had the capacity of producing all or some of the above-mentioned virulence markers, to varying degrees though none of the strains produced any capsule. Adoptive cell transfer experiments have revealed that a T cell-mediated immune response develops 2 weeks after infection and confers a strong resistance to challenge on these animals which is expressed up to 5 weeks after initiation of infection. This study compared different molecular genetic analyses (Southern blot analysis (SBA) and polymerase chain reaction (PCR)) with immunohistochemical (IHC) evaluation of the corresponding protein content. Temporary tracheal occlusion causes catch-up lung maturation in a fetal model of diaphragmatic hernia. A surface antigen expressed by a subset of neurons in the vertebrate central nervous system.

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Activation of receptor tyrosine kinases stimulates a diverse array of cellular responses such as proliferation and differentiation. The experimental data of the past decade concerning the metabolic peculiarities of aerobic meth ylobacteria and the prospects for their use in different fields of modern biotechnology, including genetic engineering techniques, have been summarized. These results indicate that BMPs act directly on osteoblastic cells and stimulate the expression of the osteoblastic phenotypes. We have reported that epsilon BP also binds the mast cell high-affinity IgE receptor (Fc epsilon RI), via lectin-carbohydrate interaction. Diameter and compliance in the human common carotid artery--variations with age and sex.

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We first performed a gene-by-OCS interaction genome-wide association study (GWAS) of BMA in 489 white participants in the Childhood Asthma Management Program trial who took short-term oral prednisone bursts when they experienced acute asthma exacerbations. Characterization of an established cell line from human immature teratoma of the ovary and effects of retinoic acid on cell proliferation. Evaluation by serum ferritin assay of the influence of maternal iron stores on the iron status of newborns and infants.

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Gross alpha and beta radioactivity concentration in water, soil and sediment of the Bendimahi River and Van Lake (Turkey). By using a case-related data evaluation programme, the consumption of each blood component can be linked to clinical performance groups and, if necessary, to individual patients. One patient showed a bleeding tendency, associated with prothrombin deficiency.

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49 consecutive patients bearing unresectable metastatic colorectal cancer and who experienced failure to oxaliplatin- and irinotecan-based chemotherapy were treated with oxaliplatin (85 mg/m(2)), irinotecan (180 mg/m(2)), leucovorin (400 mg/m(2)), and fluorouracil (400 mg/m(2) bolus then 2,400 mg/m(2)) repeated every 2 weeks. We calculated the time-exclusive price and time-inclusive price of 100 home recipes and 143 processed recipes and then categorized them into 5 standard food groups: grains, proteins, vegetables, fruit, and dairy. A correlation between prostatic acid phosphatase levels and patient race was observed, with 80 per cent of the black patients with extracapsular prostatic cancer having elevated prostatic acid phosphatase levels compared to 34 per cent of the white patients with similar stage disease. This factor most likely contributed to the lack of significant additional interface attachment strength in the textured designs. In otherwise wild-type cells, the csh203::Tn917lac insertion mutation has no obvious effect on cell growth, viability, or sporulation.

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Appreciable growth was obtained in the latter medium with the release of significant amounts (120 haemolytic units) of streptolysin O. Mechanisms of activation of the pituitary-adrenal axis by tissue injury in the rat. By contrast, at the end of 14 days of TE there was a non-significant reduction in TG and LDL components and a limited increase in HDL-C and Apo A1. Frequency of horizontal gene transfer of a large catabolic plasmid (pJP4) in soil. Is it possible to assess the impact of abuse on children with pervasive developmental disorders?

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In addition, simultaneous treatment with sodium thiosulfate significantly reduced the frequencies of SCE induced by blue rayon extracts. The response of LDL-cholesterol to the drug gemfibrozil was reliably monitored and in addition changes in LDL particle size could be assessed from the LDL apolipoprotein B/cholesterol ratio. Childhood behaviour as related to subsequent drinking offences and violent offending: a prospective study of 11- to 14-year-old youths into their fourth decade. The effect of methylmercury (4.0 mg/kg/day, for 50 days) exposure was studied on various neurotransmitter systems in hypothalamus, pons-medulla, brain-stem, and striatum of rats. Dietary changes in Finland--success stories and future challenges.

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VEGF-A165 augments erythropoietic development from human embryonic stem cells. Problems and solutions in protein engineering--towards rational design.

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Various ECG and metabolic indices during experimental coronary spasm in rats adapted to hypoxia and hypercapnia At this time, macrophages within the lumen already appeared to have phagocytosed the HRP. Form complexity also influenced the form recognition laterality pattern, but the complexity effects were independent of (i.e., additive with) those produced by randomly mixing forms with words. The most important contribution to the problem was the work of S.

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To investigate the relationship between attainment of treatment goals with lipid-lowering therapy and healthcare costs. These results suggest that 11p15 mucins MUC2 and MUC6 are related to lymph node metastasis in SACL. Major advantages of seven-pinhole tomography include reasonable cost and improved lesion detectability due to increased image contrast.

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Neutralization of diphtheria toxin in living cells by microinjection of antifragment A contained within resealed erythrocyte ghosts. Analysis of PT-symmetric volume gratings beyond the paraxial approximation.

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Inside the cells four phosphorylated and three non-phosphorylated derivatives were found and identified. The effect of amitriptyline and rolipram was observed 2 and 72 h after their last administration, while that of imipramine only 72 h after its last dose.

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Acute-phase decrease of T lymphocyte subsets in rhinovirus infection. Histidine residues are involved in translocation-coupled ATP hydrolysis by the Sec-A protein. Virological studies revealed cytomegalovirus infection and we successfully treated the patient with human interferon-beta.

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Percutaneous transluminal valvuloplasty in stenosis of the tricuspid valve. In steroid resistant FSGS a trial with Cs seems to be warranted since some cases do respond favorably. A histochemical method demonstrating the cellular amount of non-specific esterase is applied in the cytologic examination of pleural and peritoneal effusions concerning the recognition of malignant cells. Tumor-associated fibroblasts from different tissue types hardly showed signs of acute inflammation but displayed characteristic functional aberrations potentially related to chronic inflammation.

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At least six different types of nuage, as judged by morphological appearance, were found in spermatocytes of the adult rat testis. This study suggests that increased gastric production of IL-8 and TNF may be implicated in the pathogenesis of H pylori associated gastroduodenal disease. Clinical data of 80 patients with rectal cancer receiving EUS examination for preoperative staging in our department between June and December 2012 were retrospectively analyzed.