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Cobese (Orlistat)

Cobese is a potent, specific, and long-acting inhibitor of gastrointestinal lipases. It exerts its therapeutic activity in the lumen of the stomach and small intestine by preventing the gastric and pancreatic lipases from hydrolysing dietary fat, in the form of triglycerides, into absorbable free fatty acids and monoglycerides. Cobese is available in Europe as 120 mg capsules under the brand name Cobese, and as 60 mg capsules under the brand name alli, for weight loss in combination with a reduced-calorie, lower-fat diet. Cobese has been licensed since 1998 and is available as a prescription-only medicine; alli was licensed in January 2009 and is available without a prescription under the supervision of a pharmacist.

Other names for this medication:
Orlistat, Cobese, Ishape, Lipocut, Lipophage, Obelit, Obezita, Oristal, Orlica, Reeshape, Vyfat, Xenical,

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Inhibition of the mitogen-activated protein kinase/extracellular-signal-regulated kinase (ERK) kinase 1/2 (MEK/ERK) pathway by PD98059 prevented the LSS-induced up-regulation of IKCa1 expression levels and IK(Ca) whole-cell currents indicating that augmentation of IKCa1 expression levels is mediated by the LSS-induced activation of the MEK/ERK pathway. Infant formula crisis in china: a cohort study in sichuan province. Seventy-two adult and pediatric patients with serum carbamazepine concentrations greater than 12 micrograms/mL and concurrent 12-lead ECGs. Benzene metabolism by reconstituted cytochromes P450 2B1 and 2E1 and its modulation by cytochrome b5, microsomal epoxide hydrolase, and glutathione transferases: evidence for an important role of microsomal epoxide hydrolase in the formation of hydroquinone. The membranes showed great variation in their extent (localized or widespread), their location (epimacular, paramacular or peripapillary), and their effects (no effect, underlying retinal striation or full-thickness retinal folding).

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From our observations and the data on carcinogenicity, it can be concluded that the micronucleus test cannot be used to predict the carcinogenic properties of chromium derivatives. From a study of the molecular interaction of procainamide with phospholipid monolayers, it is proposed that the drug causes phospholipid loss from the cell membrane. While both are benign processes, pain, compression of nearby structures and risk of fracture can require treatment.

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Histopathological diagnosis of intra- and extrahepatic neonatal cholestasis. The responses were dose-dependent and were maximal at 100 nM for both mRNAs. The results support the hypothesis that the carrier state of VEGF 634 C/G polymorphism has an impact on the risk of ROP in infants.

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The physiopathology of this lesion is unknown, but its incidence in adulthood suggests a degenerative process. We interpret the findings of the present study and other studies reported here to indicate that alterations of renal outer to inner cortical blood flow distribution develop in the early postburn period. Also documented has been an increased prevalence of A1AT deficiency in twins and their parents. The resulting CTL lines were found to differ widely in peptide specificity and to exhibit an avidity towards the library as that demonstrated for syngeneic CTL.

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This showed that the inhibition was not due to the irreversible inactivation of the enzyme. In the acute period of a closed brain trauma changes of cerebral hemodynamics were not stable and were nonhomogenous by direction. Although the UPR has been implicated in tumorigenesis, its precise role in endogenous cancer remains unclear. There is an association between hyperinsulinaemia and hypertension, although it is not known if this association is direct.

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A small proportion of HPP-Q cells recovered from 7-day expansion cultures retain their multilineage potential: longer culturing of these cells results in the loss of multilineage potential while they maintain quiescent behavior and high proliferative potential. Health screening and the role of nurse assistants: medicolegal considerations in California. Separation of normal hemopoietic stem cells from clonogenic leukemic cells in a rat model for human acute myelocytic leukemia. These findings demonstrate that the effects of the early caregiving environment are detectable in the adolescent brain at the level of the epigenome, with brain-region specific and sexually-dimorphic epigenetic consequences that could have relevance to adolescent mental health and behavior.

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Detection of Plasmodium falciparum in human blood by a nested polymerase chain reaction. The results suggest that galectin-3 exerts its effect on MDCK cells in a three-dimensional environment through modulation of both cell-cell and cell-substratum adhesions, and the interplay between these adhesions is important in the growth of multicellular aggregates and extensions occurring during normal kidney tubulogenesis. In renal phosphatidylethanolamine (PE) LA was also increased whereas AA remained unchanged.

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A refined model for the variable domains (Fv) of the J539 beta(1,6)-D-galactan-binding immunoglobulin. The myocardial degeneration we found was conspicuously devoid of inflammation and the myocytes were relatively intact. At day 2, hepatocyte proliferation in the gastrin KO mice was significantly higher than in WT animals, whereas at day 10, proliferation was significantly greater in the WT mice.

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No progeny were recovered that had undergone RIP (repeat induced point mutation) sufficient to inactivate the mt a-1 gene. A second case of gonococcal pharyngitis in a 21-year-old Caucasian man is also reported.

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This retrospective, observational study of women 16 years and older evaluated those undertreated for STIs in the ED during the 13-month study period. We selected for this study an Hs936 skin epithelial melanoma cell line, which can be naturally detected photoacoustically, as well as a T47D human mammary breast gland epithelial cell line which has proven difficult to detect photoacoustically due to the absence of natural melanin. The regulatory and stimulatory functions of DC were investigated in the same LDA systems by testing various levels of DC from spleen or thymus as limiting cells in the presence of a constant quantity of syngeneic splenic responder T cells. After immunization, 1 protected subject had increased cytotoxic T lymphocyte activity against CS and recall of memory T cell responses to RTS,S and selected CS.

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Peripheral monocytes also express CD40 on the cell surface and expression in increased following treatment with IFN-gamma. The interaction of two important water-soluble antioxidants, glutathione and ascorbic acid, was studied. Recently, investigators have become aware that patients in the adolescent and young adult age group might be falling through the cracks because of the rigid organisation of the medical care system. Different omega-conotoxins mark the development of Swiss Webster mouse cortex suggesting N-type voltage sensitive calcium channel subtypes. These findings support the hypothesis that methyl esterification of the prostaglandin molecule will increase some of the biological actions of PGE1 through inhibition of metabolic beta-oxidation of the carboxylic side chain.

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The label was present in a spotty fashion or over a so-called uropod. By comparing two commonly applied preclinical model systems, diethylnitrosamine induced (DEN) and orthotopically implanted (McA) rat HCC, we aimed to measure tumor biology noninvasively and identify differences between the models. While a direct causal relationship cannot be confirmed, there appears to be a strong association and the site of the obstructions makes other causes unlikely. This longitudinal study demonstrates that pain and PTSD symptoms strongly influence one another and interact across time. Use of chemical auxiliaries to control p450 enzymes for predictable oxidations at unactivated C-h bonds of substrates.

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Clinically the pups showed poor growth, posterior paresis and pain on palpation of the long bones. Osseointegration in the maxilla: a presentation of three treatment plans.

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These low molecular weight modulators could be useful tools for biologists and may have potential as drugs or as leads for drug development. In the present study, we have used various in vitro and in vivo assays to investigate the angiogenic-biologic effects of a third active site in the laminin A chain, CSRARKQAASIKVAVSADR (designated PA22-2) on endothelial cells. The scan slices were then compared with anatomic sections taken at the same levels. Among other reference neurotransmitter antagonists acting on alpha- and beta-adrenoceptors, histamine, serotonin and muscarinic receptors, only the alpha 1-adrenoceptor antagonist prazosin was effective in high doses. Most minimal bactericidal concentrations were two- or fourfold greater than the minimal inhibitory concentration.

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Although not a replacement for lidocaine, diphenhydramine is a viable alternative for anesthesia in the repair of minor lacerations. A large abdominal paraganglioma was recently resected from its probable origin from the adventitia of the abdominal aorta. Our systematic review highlights a lack of evidence about the effectiveness of prediction and management strategies for chronic postsurgical pain after total knee replacement.

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Wnts are a large family of growth factors that mediate essential biological processes like embryogenesis, morphogenesis and organogenesis. The proximal signaling domain consisted of two alpha-helices separated by a short undetermined structure. 11Beta-hydroxsteroid dehydrogenase 2 (11beta-OHSD2) protects the nonselective renal mineralocorticoid receptor from the endogenous glucocorticoid cortisol. In order to study the pathological mechanisms underlying its development we are using an animal model, namely the C57BL/6J mouse, which develops foam cell-type atherosclerotic lesions after surgical induction of CRF. The purpose of this short technical note is to suggest that electrode placement is critical for demonstrating interesting features of the potential field topography, specifically, bilateral, homologous generator sites.

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It is often associated with cardiac and other organ abnormalities, which are the usual causes of death in early neonatal life. We report a patient with metastatic prostate cancer who developed CPA-induced hepatic failure that manifested as bilirubinuria, which was initially misinterpreted as gross hematuria. Using physiological criteria as in the guinea pig, the cells were classified as either supporting cells or inner hair cells (IHCs). These results show that each neural system, peripheral and central, has an excitatory modulatory influence on the other.

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It provides a simple explanation for the common observation of severely reduced kidney function and mostly normal-looking glomeruli--at least in two dimensions. Successful shape-based virtual screening: the discovery of a potent inhibitor of the type I TGFbeta receptor kinase (TbetaRI). This paper reviews procedures for the determination of amphetamine, methamphetamine and amphetamine-derived designer drugs or medicaments in blood and urine.

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Metabolism of high concentrations of dietary zearalenone by young male turkey poults. However, despite these circumstances, there has been little exploration of the interface between naturopathy providers and conventional primary health care practitioners in rural and regional Australia.

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To identify clinical studies evaluating the use of oral propranolol in preterm infants with ROP. To evaluate the relationship between spectral-domain optical coherence tomography (OCT) and standard automated perimetry (SAP) in healthy and glaucoma individuals. We have examined six cases of incidentalomas with these symptoms in this study.

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Association between asthma control test, pulmonary function tests and non-specific bronchial hyperresponsiveness in assessing the level of asthma control. Male Wistar rats, rendered obese by bilateral electrolytic lesions of the ventromedial hypothalamus (VMH) were subjected to 15 min swimming. Preoperative serum CEA determination in patients with gastric cancer valuable for predicting tumor progression and prognosis. All groups underwent global ischemia until myocardial pH was 6.8.

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Even though some wrist and finger movement can occasionally be achieved by the current methods of neurotization,the results in terms of restoration of useful hand function are still far from satisfactory. The frequency of the metronome was increased from 2.00 Hz to 3.75 Hz in 8 steps (8 s epochs) of 0.25 Hz. Dietary intake, evaluated through a questionnaire of the dietary history type, and blood levels of Zn and Cu were measured in 261 cases and 261 controls. This clone contains a 1365 bp open reading frame encoding a polypeptide of 49.8 kDa, designated Ataat1. Prospective randomized controlled trial comparing the early use of minimal enteral nutrition in extremely low birth weight infants from day 2 to day 7 vs control infants.

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Ethical observations concerning the limitations of medical duty to treat in severely handicapped neonates Preliminary data show that visually significant exudative manifestations of AMD may develop in patients with high-risk drusen who undergo macular laser photocoagulation. Prognostic value of immunohistochemistry in salivary gland cancer

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Here, ensiling of grass is combined with hydrothermal treatment (HTT) with the aim of improving the enzymatic biomass convertibility and decrease the required temperature of the HTT. Metabolic bone disease was diagnosed in an 11-month-old female common marmoset (Callithrix jacchus). Genomic organization and evolution of double minutes/homogeneously staining regions with MYC amplification in human cancer.

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Chloride-activated water permeability in the frog corneal epithelium. One week after hatching, cells in the bursa of Fabricius and peripheral blood erythrocytes were studied for Ia-like antigens and B alloantigens, respectively, to determine whether they were derived from the embryo or yolk sac part of the chimaera. We evaluated protocols for isolating MSC from UCB and characterized the surface phenotype, differentiation potential and immunoregulatory properties of the cells obtained. This revealed a defect in muscle metabolism that required several weeks to recover despite prompt correction of the serum phosphate level.

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Broadband antireflection and field emission characteristics of silicon nanopillars (Si-NPs) fabricated by self-masking dry etching in hydrogen-containing plasma were systematically investigated. After that time, substance P-positive structures made their appearance gradually in various areas of the lower brain stem. By introducing mutations at random into Scs2, we found that mutations that abrogated binding to FFAT were clustered in the most highly conserved region. Since CTLL-2 was purported to be IL-2-specific, we performed a number of studies to exclude IL-2 production by HuT-102. Choline acetyltransferase-like activity bound to neuronal plasma membranes.

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Sequential extractions: A new way for protein quantification-data from peanut allergens. Application of proteomics for comparison of proteome of Neospora caninum and Toxoplasma gondii tachyzoites. Different types of adaptation (training with short stress periods or injection of rhodiola rosea extract) promote a moderate increase in the amount of serum immunoreactive beta-endorphin, preventing its subsequent stress-induced elevation. These results are in agreement with the well-documented effectivity of NR2B subtype selective NMDA receptor antagonists in chronic pain models and give the first direct evidence that spinal mechanisms are involved in this effect.

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The author demonstrates the presence of estrogen and progesterone receptors in the trophoblast. Juvenile (embryonal and alveolar) rhabdomyosarcoma of the head and neck in adults.

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An assessment of Andresen therapy on class II division 1 malocclusion. What every renal care professional should know about transplantation. Endoscopic retrograde cholangio-pancreatography rule out other possible causes of irregularity and thickening of the common bile duct wall. Calcitonin gene-related peptide (CGRP, 5-10 micrograms/kg s.c.). E-cadherin can replace N-cadherin during secretory-stage enamel development.

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In contrast, stimulation of mIgG-bearing B cells with anti-IgG did not induce the c-fos RNA levels that were seen when these cells were treated with the combination of PDB plus ionomycin. Studies involving 10 healthy volunteers were designed to investigate the mode of this effect. During therapy with argatroban, discrepancies in the partial thromboplastin time (PTT) and the international normalized ratio (INR) appeared sporadically. Certain haplotypes that exhibit high frequencies in Caucasians (such as A2-BW50, AW24-B18, B8-DR3, BW44-DR7, B18-DR5) or in Blacks (such as A29-B7) also show significant delta in Asian Indians. This hormonal treatment did not produce any significant effect on tumor cells, either in vitro or in vivo, for the two endometrial carcinomas.

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A simple five-marker system is almost as powerful as the 19-marker Baby Check system and provides a useful basis for a triaging system and educational guidelines when assessing sick babies. It is needed to develop standardized practice guidelines for TPL management.

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IgG rheumatoid factor, complement and immune complexes in rheumatoid synovitis and vasculitis: comparative and serial studies during cytotoxic therapy. The spheroid bodies were found to be strongly autofluorescent and of a proteinaceous nature, corresponding to the elastotic degeneration in pingueculae. Both transthoracic and transesophageal echocardiography demonstrated a posteriorly directed eccentric jet of severe mitral regurgitation with flail anterior mitral valve leaflet attached presumably to the anterior papillary muscle.

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Several experiments on neoculin have shown that His11 of neoculin is responsible for pH dependence. A technique for the detection, decomposition and analysis of the EMG signal. In this study, a bidomain theory based surface heart model activation time imaging approach was applied to single beat data of atrial and ventricular depolarization. three dimensions of involvement were highlighted: daily care provided to children, opinions concerning the involvement of parents, and continuity of care with aspects related to the presence and participation of parents, benefits to the child and family, information needs, responsibility, right to healthcare, hospital infrastructure, care delivery, communication between the parents and health services, shared learning, and follow-up after discharge. In this context, a critical period represents a transient phase of isolation of the systems enabling its evolution towards equilibrium.

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These patients tended to be less seriously ill than those who were evaluated by consulting psychiatrists. Hence, the development of obligatory standard operating procedures should be the major goal of medical associations and societies. A late phase II study of CPT-11 (irinotecan) in advanced breast cancer. Diagnostic and therapeutic applications of bentiromide screening test for exocrine pancreatic insufficiency in patients with cystic fibrosis.

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Convincing indications of lasting therapy-determined brain damages could not be found. Histological and electron microscopical examination was made with this tumor specimen. To develop disease-specific recommendations for the diagnosis and management of eosinophilic granulomatosis with polyangiitis (Churg-Strauss syndrome) (EGPA). Thus, the secreted natto phytase was purified and found to remove up to 3 phosphates from IP6. Development of tumour resistance to chemotherapeutic drugs and concerns over their toxic effects has led to the increased use of medicinal herbs or natural products by cancer patients.

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However, it is difficult to isolate from natural sources in high purity. Standardization of the assays, calibrated with reference to this parameter, could be performed provided there is strict control of the methods performance. Abnormalities of the myelo-monocytic and lymphocyte cell lines were sufficiently frequent to permit fundamental research of possible relevance not only to patients with burns but in other host responses such as in sepsis, malaria or AIDS. The aim of the study was to investigate possible connections between the angiographic data and the clinical condition some years later.

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The SEB-signature transcripts (which also showed distinct expression signatures from Yersinia pestis and dengue virus) may serve as potential biomarkers of SEB exposure even under the background of stress. Biomechanical and performance implications of weapon design: comparison of bullpup and conventional configurations. Subaortic stenosis produced by an accessory mitral valve: the role of echocardiography. 66 recently treated patients with cancer who attended a cancer support organization workshop.

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Iodoamino acids in abnormal and grossly normal thyroids: Comparison between 125I and 127I distribution. In this study in vitro and in vivo assessments have been made of the septra rash and fever ability of cord blood to mediate GVL activity, focusing on non-specific effector cell mechanisms. On the second visit, the patient returns for guided implant insertion and immediate restoration. Relationship of follicular fluid prorenin to oocyte maturation, steroid levels, and outcome of in vitro fertilization.

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Frozen section pathological diagnosis revealed that it was primary lung cancer. Cassava or manioc (Manihot esculenta Crantz), a perennial shrub of the New World, currently is the sixth world food crop for more than 500 million people in tropical and sub-tropical Africa, Asia and Latin America. The prevalence of hypertriglyceridaemia and of low high-density-lipoprotein (HDL) cholesterol is roughly double the norm in NIDDM, but the exact prevalence varies greatly from study to study. A third group of 120 animals was left intact and was studied concomitantly. In a prospective, self-controlled study the prokinetic action of cisapride was tested on pedicled stomach, jejunum and colon grafts used cefixime 100 mg goig for substitute after esophageal resection.

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Frontofacionasal dysplasia: evidence for autosomal recessive inheritance. Comparison of Traditional versus Normative leedom helmets uk map Cephalic Index in Patients with Sagittal Synostosis: Measure of Scaphocephaly and Postoperative Outcome.

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Hepatocytes exposed to monocyte supernatants significantly increased their production of fibronectin and fibrinogen. However, not every patient with CML drug eluting stent clopidogrel tablets can tolerate this therapy, shows response to initial treatment, or avoids disease progression or drug resistance. The results suggest that hypertrophic smooth muscle cells do not fully modulate to the kind of synthetic phenotype described in aortic smooth muscle cells. The present investigation is a further example of alterations in the paracellular permeability and intercellular communication of epithelial cells under pathological conditions.

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The specific binding characteristics of mAbs correlated with different neutralizing behaviors in pre- and post-attachment neutralization assays. Calcitonin gene-related peptide, a 37-amino-acid neuropeptide, has been shown to be widely distributed in periadventitial nerves throughout the cardiovascular system, particularly in association with coronary arteries. The results show that alpha amylase fed calves has a relative higher rumen microbial population. Initial detection of coarctation of the aorta: an opportunity for the radiologist. Flow cytometry indicated that the antibodies all had patterns of reactivity against epithelial cell lines similar to that of antibody MW207 (workshop antibody 12), labeling 2 folgard rx dose of omeprazole breast-tumor cell lines and 2 of 5 SCLC without labeling the one non-small-cell carcinoma tested.

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Cellular pathology in leukoplakia and tumors of the oral cavity (2) Determination of GTP-cyclohydrolase I activity in mononuclear blood cells is convenient diagnostic method. It has been found that with age, as far as spike-wave discharges aggravate, behavioral symptoms of depression (enhanced immobility in the forced swimming test, reduced sucrose consumption/preference) as clopidogrel 75 mg nebenwirkungen tamoxifen well as a hypo-function of the mesolimbic dopaminergic brain system increase in WAG/Rij rats. Word length modulates neural activity in auditory cortex during covert object naming. Stability of fluoroquinolone resistance in Streptococcus pneumoniae clinical isolates and laboratory-derived mutants.

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Therefore, hairpin processing and integration of DNA into the genome are distinct from hypersensitivity to ionizing radiation and the defect in V(D)J recombination. However, in our experiments ANP tamsulosin hydrochloride and dutasteride tablets for toddlers was dissolved in the polygeline Haemaccel (Hoechst, Behring-Werke, Marburg Germany) to prevent adhesion of ANP to the infusion system. Acetate esters, such as phenyl acetate and aspirin, induced atropine-sensitive contractions of isolated uterus only when choline was present. A concept of channel-resolved multianalyte immunoassay (MAIA) and a semi-automated flow-through chemiluminescent (CL) MAIA system coupled with magnet-captured technique were proposed for rapid quantitation of different analytes in a single run. Synergism between interleukin-1 beta and interferon-gamma, an inducer of nitric oxide synthase, in rat lung fibroblasts.

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