Atazanavir is a protease inhibitor that, when given with a pharmacokinetic enhancer (ritonavir or cobicistat), is a potent, once-daily anchor agent for antiretroviral therapy. In the past, it was prescribed frequently for initial treatment, but in recent years several newer and better-tolerated anchor drugs have largely replaced Atazanavir in clinical practice. Atazanavir causes indirect hyperbilirubinemia that can lead to jaundice, which is benign but can be cosmetically bothersome, especially with icterus; it can also cause nephrolithiasis and gallstones. In addition, concomitant use of certain acid-suppressive agents can significantly decrease absorption of Atazanavir. If a patient is taking Atazanavir as part of combination antiretroviral therapy and is tolerating it well with consistently suppressed HIV RNA levels, it is not necessary to change Atazanavir to another agent, though most clinicians have a low threshold to switch the regimen if the patient has troublesome side effects. Atazanavir can be given either with or without a pharmacokinetic booster, though current guidelines recommend that it be combined with a pharmacokinetic enhancer and advise against use of unboosted Atazanavir.
Other names for this medication:
Atazanavir,
Atazor,
Reyataz,
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