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These results together with the identification of a maternal mRNA with strong homology to TGF-beta, suggest that molecules closely related to FGF and TGF-beta are the natural inducers of mesoderm in vertebrate development. Osteoarticular manifestations in children with systemic scleroderma

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immitis were observed in lung, perihilar lymph nodes, and brain. PHIL (Precipitating Hydrophobic Injectable Liquid) (Microvention, Inc California, USA) is a new liquid embolic agent, CE marked and available for clinical use in Europe.

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Expression of nerve growth factor and trkA after transient focal cerebral ischemia in rats. The changes in the ECG were similar to those observed in the myocardium dystrophy. Physiological, clinical and therapeutical basis of a new hypothesis for headache. Oropharyngeal tularemia: an uncommon cause of pharyngitis, fever, and adenopathy.

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Regulation of factor VIIa activity in plasma: evidence that antithrombin III is the sole plasma protease inhibitor of human factor VIIa. In addition, a clear correlation was seen between the sensitizing potential and chemical structure of the local anaesthetics. The synaptotagmin juxtamembrane domain is involved in neuroexocytosis.

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A new syndrome of congenital hypoparathyroidism, severe growth failure, and dysmorphic features. Nonviable bacterial antigens administered with IL-12 generate antigen-specific T cell responses and protective immunity against Listeria monocytogenes. Two experiments were performed to test the reliability and validity of psychophysically determined maximum acceptable workloads for setting lifting standards.

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Five weeks post-injection Schwann cell remyelinated fibers were present along the surface of the dorsal columns and around blood vessels within the lesions. Nineteen months after the initial presentation, a second tumor at the dome of the right lobe liver was found. The predicted sequences of murine Lis1 protein and its human homolog LIS1 are virtually identical. In parallel microdialysis experiments, both strains showed significant dose-related increases in dopamine release in the nucleus accumbens following acute morphine challenge (1.0-10.0 mg/kg SC). Echocardiography revealed that the timing of the diastolic TR (and noted MR) coincided with the second phase of the pulmonic insufficiency (PI) jet.

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Frustration of ferroelectricity in epitaxial film of relaxor ferroelectric PbSc1/2Nb1/2O3. In this work, eight genes required for the catabolism of protocatechuate were localized within a 13.5-kb SalI region of DNA. The in vivo mutagenic frequency and specificity of O6-methylguanine in phi X174 replicative form DNA. miR-122 levels did not correlate with disease severity or mortality in critically ill patients.

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One monoclonal antibody 115A10 (MAb 5A10) specifically stained a subpopulation of retinal bipolar cells in various vertebrates. Genetic epidemiology as a tool for investigating rheumatic disease.

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Subjects reported strain and burden independent of other current stressors in their lives. Effects of partial silencing of genes coding for enzymes involved in glycolysis and tricarboxylic acid cycle on the enterance of human fibroblasts to the S phase. A new pharyngopalatoplasty procedure utilizing a palmaris longus tendon graft has achieved consistently gratifying results in selected patients with functional palatal musculature. The balance of serine proteases and inhibitors in nerve and muscle is altered during programmed- and injury-induced remodeling. We now document that mutation in the GADD34 gene is a frequent event during transformation and/or immortalization of rodent cells.

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Indomethacin and aspirin prevent the starvation-induced fall in plasma insulin. The acetabular and glenoid areas, the costochondral junctions and the sternal ends of the clavicles were also involved.

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At substrate concentrations at which native alpha 1-PI was readily degraded by macrophage elastase, oxidized alpha 1-PI was hardly degraded at all. Black aspergilli were predominant among the different Aspergillus spp. One must attempt to lower portal pressure with drugs such as propranolol and/or undertake portal decompressive surgery. To assess the efficiency of pulse-dose radiofrequency (PDRF) in the management of chronic pain in patients with trapezio-metacarpal osteoarthritis (OA). Basic principles of the rehabilitation process of the mental patient

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Decrease in male fertility observed in the past decades have involved sperm quantity and quality disorders. This study shows that the range of histologic features in craniopharyngioma includes and spans both odontogenic lesions but more often simulates KCOC.

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Eighty male volunteers participated in an analogue study of the effects of alcohol intoxication at the time of a crime on the physiological detection of deception using control question and guilty knowledge techniques. In addition to smoking, other contraindications include women with a history of angina, myocardial infarction, blood clots or stroke, estrogen dependent cancer, hypertension, a known lipid disorder, and women with hepatitis or cirrhosis of the liver.

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Providing surrogate endpoints in clinical trials, medical imaging has become increasingly important in human-centered research. Effects of the putative substance P antagonists (D-PRO2, D-PHE7, D-TRP9, and D-PRO2, D-TRP7, D-TRP9) on electrical activity of myenteric neurons. Second, we introduced a validated quality metric, the Clinical Performance and Value vignette, to a sample of cardiology providers to examine clinical practice variation in treating coronary heart disease (CHD), coronary heart failure (CHF), and atrial fibrillation (AF).

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In this study, to utilize CNTs in bulk scale electrode applications, we developed a dry spinning technique. The small number of deaths limited the statistical power of the analyses. No significant difference in allele frequency was found between 33 unrelated individuals with FCHL and 107 normolipidemic controls. The pharmacokinetics of thyrotropin-releasing hormone (TRH) and deamido-TRH in the rat.

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Ovariectomy led to reduced synthesis of IL-1 by PAC but estradiol replacement therapy of such rats effectively increased IL-1 synthesis. Standardized data collection was performed with a short version of the questionnaire issued by the German Stroke Registers Study Group (ADSR). The chemical results were almost identical in the two subgroups of patients, although they differ in neuropathological patterns of lesions. Despite strict traffic legislation, road traffic accidents are the main cause of maxillofacial injuries.

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RF ablations were performed using steerable Mansfield (Webster Laboratories) 4 mm tipped electrodes and locally assembled RF energy delivery system. Our results demonstrate that there are trophoblast products which could cause the maternal syndrome of pre-eclampsia through endothelial cell damage. Comparison of Rhys Hearn method of determining nursing staff requirements with the Aberdeen formula. The specular photomicrographic appearance of cornea guttata is described in both donor material and in patients. Two patients were studied using T-cell and B-cell specific fluorescent staining, which revealed that the interstitial infiltrates were composed exclusively of T-lymphocytes.

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It is the combination of G-CSF and antibiotics, however, that is clinically relevant. The fossil has striking similarity to the extant myodocopid family Cylindroleberididae, to which it is assigned, and demonstrates remarkable evolutionary stasis over 425 million years. Typically, surviving cells show a high content of RNA and protein. At the same conditions control cultures of parental strains and clones did not exhibit resistance that excludes the possibility of origin of cells resistant to both antibiotics from Crithidia of one of the parental strains as a result of secondary mutation.

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As the adenosine receptors are important for cardiac pre-conditioning and post-conditioning, adenosine may regulate the inflammatory responses initiated during ischemia-mediated immune injury related to myocardial protection. In regions where the patients differed significantly from the controls, no significant differences in mean volume between patients with schizoaffective disorder and patients with schizophrenia in any of five regions of volume reduction were found, but mean volumes in the patients with bipolar disorder were significantly smaller in three of five. Using three different assays, we were unable to observe inhibition by the synthetic peptide.

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Estimating the formula for the flow length y, it was found that y was represented by the sum of the first order formula of A and B. Base hydrolysis and amino acid analysis for phosphotyrosine in proteins. According to the economical principle to obtain the highest advantage with the minimalst engagement for the society we passed over in geriatrics from the individual physiotherapy to the therapy in the group, which was very successful in our institution. Co-cultivation of cells with MTX and folinic acid reversed the effect of MTX on polyglutamate formation, DNA synthesis, and cell growth.

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We aimed to evaluate the placental volume and placental mean gray value in preeclampsia and healthy placentas by using three-dimensional (3D) ultrasonography and Virtual Organ Computer-aided AnaLysis (VOCAL). Cost-effectiveness of invitation to food supplementation early in pregnancy combined with multiple micronutrients on infant survival: analysis of data from MINIMat randomized trial, Bangladesh. Recent research into the inflammatory component of multiple sclerosis (MS) indicates that, as expected, pleiotropy and redundancy characterize various physiopathological mechanisms of the disease. The antinociceptive effects of tramadol combinations, are partially due to the activation of MOR, DOR and KOR opioid subtypes. These results, in conjunction with trends in tobacco consumption, indicate that mortality from lung cancer in both men and women will increase substantially through the early part of the 21st century in Korea.

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Glucosyl-transferase is a soluble protein of the endoplasmic reticulum that recognizes protein domains exposed in denatured but not in native conformations (probably hydrophobic amino acids) and the innermost N-acetylglucosamine unit that is hidden from macromolecular probes in most native glycoproteins. The gene for spherocytosis, therefore, is likely either very close to the centromere of chromosome 8 or on 12p. Changing blood use in the AIDS era: the case of elective hip surgery. This was manifested by low isolation rate of virus in the interepidemic period, reduced hemagglutinating, interfering, and immunogenic activity of these viruses, poor reproduction in the lung tissue of white mice and the lack of virus-specific syntheses in splenocytes of infected Syrian hamsters. Cholesterol is excreted into the bile directly or after conversion to bile acids, which are also present in the plasma as they are effectively reabsorbed through the enterohepatic cycle.

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Recently, we translated this strategy into a first clinical phase I/IIa trial and observed no side effects, and preserved or even increased C-peptide responses to a mixed meal tolerance test during the first year after treatment. Microscopic findings and functional studies indicate that this barrier might be impaired in patients with non erosive reflux disease (NERD) but not in patients with functional heartburn (FH). ArsS and ArsR work through phosphorylation-dependent and phosphorylation-independent regulatory mechanisms to impact acid acclimation and allow gastric colonization. The putative trans-activator protein was immunoprecipitated from overproducing stable cell lines and shown to migrate as a 14-kilodalton polypeptide on sodium dodecyl sulfate-polyacrylamide gels.

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This approach is more sensitive than conventional slot blot analyses in detecting radiolabeled nascent transcripts and is efficacious in cell systems supporting inherently low levels of virus gene expression. Chemoattractant increased surface staining of elastase and the cleavage of elastase-specific fluorogenic substrate by neutrophils.

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Scheduling of fluorouracil: a forget-me-not in the jungle of doublets. The objective of this study was to provide insight into how advanced cancer patients and their caregivers use a Question Prompt List (QPL) during a consultation and for preparation for future consultations.

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Reaction rate constants (k.yr-1) of racemization of Asp, Glu and Ala in antemortem teeth were 5.3825 x 10(-4), 5.1000 x 10(-5) and 2.3875 x 10(-5), respectively. YST-1 cells were considered to be of value for studying the nature and histogenesis of EMS. The spheroid showed well-defined cellular morphology and clear boundary between two cell lines.Significant expression of Cx43 was found along the boundary.SW620 cells had no expression of Cx43 when cultured alone, while the expression of Cx43 was induced upon co-culturing with fibroblasts.In the colorectal cancer tissue, expression of Cx43 was minimal in the centre of tumor in contrast to an upregulated expression at invasive front. Although H2-receptor antagonists were given, she had to be admitted due to chills and high fever.

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Clinical experience with cyproterone acetate in a randomised and in an open trial. Evidence from a context discriminatory task and a newly developed task that depends on the ability to distinguish discrete auditory cues indicated that CBP-dependent neural signaling within the mPFC circuitry is an important component of the mechanism for disambiguating the meaning of fear signals with two opposing values: aversive and nonaversive. The results of quantitative RT-PCR showed that expressions of CCL13 and HSPC159 mRNA in nephrosis PBMC samples were higher than those in remission samples from all 24 MCNS patients examined, while these mRNA expression patterns were variable among 10 MN patients.

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Quantification of the relative importance of, and the effect of nutritional status on, the individual pathways of tryptophan metabolism. A heat-stable extracellular protease from Pseudomonas fluorescens was purified by chromatography on a DEAE-cellulose column and gel filtration on a Sephadex G100 column. The question that lingers is whether the blood supply at the radial attachment is sufficient for healing.

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Nor were significant differences found in these respects between individuals with and without a caries increment during the observation period regardless of grouping. To develop a procedure for noninvasive measurement of language lateralization with functional magnetic resonance imaging (MRI).

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These findings suggest that neural activity in brain regions previously associated with symptom provocation in specific phobics and subjects with posttraumatic stress disorder also are involved during panic in healthy individuals. Local activation of the monocyte-macrophage system in experimental contact dermatitis of the guinea pig. The L-arginine/nitric oxide pathway in the rabbit urethral lamina propria.

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protein core, link protein as well as glycosaminoglycans were decreased in the tissue after treatment with tolfenamic acid. Morphology and dendritic domains of neurons in the lateral parabrachial nucleus of the rat. Existence of the HBV infection made us avoid to increase the corticosteroid dose or to use other immunosuppressants such as azathioprine or infliximab. The data suggest that this HTS format will be useful for the identification of better lead compounds for developing new therapeutics for FXS.

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Autoimmune hemolytic anemia caused by use of alpha-methyldopa (Aldomet) These results indicate that hypothalamic dopaminergic neuron and its postsynaptic dopamine receptors relating to GH secretion might be impaired. Osteoarthritis of the knee: correlation of subchondral MR signal abnormalities with histopathologic and radiographic features. Incidence and risk factors of low-back pain in middle-aged farmers. The aim of this study was to evaluate the diagnostic value of modern imaging tools in pulsatile tinnitus, which might be apparent in a variety of different diseases.

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Correlation with phenotype and other known Y chromosome markers establish that the Y-chromosome-specific reiterated DNA discussed here has no evident role in male determination. Providing these tools supports the provision of trauma-informed care. The inhibition induced by pokeweed mitogen-stimulated T suppressor cells was not affected by the antibody treatment, suggesting that these two inhibitory cells recognize different target structures.

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Acid phosphatase staining pattern as an indicator of T-cell acute leukemia. T-lymphocytes of the cerebrospinal fluid in meningoencephalitis (preliminary report) Identical results were obtained using purified R1 isolated from infected cell extracts or following expression in Escherichia coli.

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Peritoneal macrophages from aged rats produced EP/IL-1 as well as young adult rats. Six groups of five each were assigned as follows: thoracotomy control groups treated with reamed or unreamed nailing, lung contusion groups treated with reamed or unreamed nailing, and shock and lung contusion groups treated with reamed or unreamed nailing.

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This stimulation required protein synthesis as shown by inhibition with cycloheximide. The alteration effected by the act-1 mutation, which was dominant in diploids, was localized to the large subunit of the cytoplasmic ribosomes, but no ribosomal protein alterations were detected using two-dimensional gel electrophoresis. The objective was to evaluate the effect of chronic D2-dopamine receptor inhibition on gall-bladder emptying in diabetic patients. Primary care professionals should be proactive in partner notification of STIs.