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Sporanox (Itraconazole)
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Itraconazole

Sporanox, a common triazole anti-fungal drug in widespread clinical use, has evidence of clinical activity that is of interest in oncology. There is evidence that at the clinically relevant doses, Sporanox has potent anti-angiogenic activity, and that it can inhibit the Hedgehog signalling pathway and may also induce autophagic growth arrest. The evidence for these anticancer effects, in vitro, in vivo, and clinical are summarised, and the putative mechanisms of their action outlined. Clinical trials have shown that patients with prostate, lung, and basal cell carcinoma have benefited from treatment with Sporanox, and there are additional reports of activity in leukaemia, ovarian, breast, and pancreatic cancers. Given the evidence presented, a case is made that Sporanox warrants further clinical investigation as an anti- cancer agent. Additionally, based on the properties summarised previously, it is proposed that Sporanox may synergise with a range of other drugs to enhance the anti-cancer effect, and some of these possible combinations are presented in the supplementary materials accompanying this paper.

Other names for this medication:
Itraconazole, Sporanox, Fulcover, Icoz, Candistat,

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(3) Besides, stress responses were measured on 31-items on the difference between present and past levels. Identification of chemoresistant factors by protein expression analysis with iTRAQ for head and neck carcinoma. Increasing the yield of primary care-oriented practitioners from residency programs in internal medicine.

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Of the three ethylenediaminetetraacetic acid (EDTA) salts used for anticoagulation of blood specimens for hematologic testing, potassium salts are the most readily soluble. Effects of 12 months quinapril therapy in asymptomatic patients with chronic aortic regurgitation.

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Increased vascular permeability in rat nasal mucosa induced by substance P and stimulation of capsaicin-sensitive trigeminal neurons. These pressures can lead to pathogen-specific, ubiquitous dynamic behaviours. Regional analysis of the kidney was attempted by evaluating the independent responses of the renal parenchyma and renal pelvis to a bolus injection of 99mTc-DTPA.

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Its unique properties of biocompatibility, biostability and permanent adherence to bone make this new material very useful in head and neck surgery. Interrelationship between the immunological and steroid hormone parameters in rheumatoid arthritis. Observations suggest that the intracellular movement and release of vaccinia virus utilize a host cell cytoplasmic network that involves microfilaments for stability.

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a method to measure 2D K(2)SNR associated with grid use in digital radiography system was developed and validated. Patients on mechanical ventilation are occasionally hard to wean because of fatigue and/or depression. OAV has a unique fiber and a penton protein that lacks a recognisable integrin-binding motif.

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Metyrapone, a corticosterone synthesis inhibitor, has been demonstrated to reduce cocaine-related behaviors, especially in a low-dose combination with oxazepam, a benzodiazepine. This method reduces swelling and damage in superficial layers of the slices and improves the success rate for targeted patch clamp recordings, including recordings from fluorescently labeled populations in slices derived from transgenic mice. Experience gained from open biopsy facilitates the development of the percutaneous technique. In the search for therapeutic approaches, focused modalities which specifically target hypoxia have been particularly sought. The unique challenges faced by psychiatrists and other mental health professionals working in a multicultural setting.

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Three-dimensional MRI scanning was carried out on the L3-4, L4-5, and L5-S1 discs. The pathogenesis of this phenomenon nearly always involves acute thrombosis superimposed on a disrupted atherosclerotic plaque. In the present study, we examined the possibility that the genotype of the ACE gene might influence the development of left ventricular hypertrophy. In these animals, the response of the cerebral circulation to changes in PaO2, PaCO2, and MABP was determined before and after fentanyl administration.

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A 4-year-old girl developed a recurrent abdominal pseudocyst from a ventriculoperitoneal shunt. Excretion of the dopamine metabolites homovanillic acid and 3-methoxytyramine did not change. Vaterite was observed in 5 of the samples, whereas aragonite was found in 1 sample. Evaluation of the pulse-wave form by means of the harmonic Fourier-analysis in aortic valve insufficiency

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The pre-penetration binding interactions between gametes of the golden hamster were investigated in vitro. Nonalcoholic fatty liver disease (NAFLD) is linked to obesity, metabolic syndrome, and cardiovascular disease. Behavioral characteristics of adolescents as determined by brain neurophysiological and neurochemical processes during puberty are the focus of this article.

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Both parents were carriers for the R383Q variant, suggesting that R383Q is a recessive mutation. Long-term survivors who received intracardiac medications from paramedics were compared to a control group resuscitated by paramedics with intravenous medications alone. In contrast to BPV-1 E5, HPV-16 E5 does not activate growth factor receptors, phosphoinositide 3-kinase or c-Src, and fails to induce focus formation, although it does promote anchorage-independent growth in soft agar. Injection and sexual risk practices among young heroin users in Hanoi, Vietnam.

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The women were interviewed in their rooms on postpartum day 2 or 3 and by telephone 6 weeks, 3 months, 6 months, and 12 months postpartum. Renal cell carcinoma is a common malignancy that often presents as a metastatic-disease for which there are no effective treatments. Efficacy of cumulative doses of salbutamol administered via Turbuhaler or Diskhaler in patients with reversible airway obstruction.

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The immunization with CFA alone was also effective in preventing neuronal cell death, but the magnitude of the neuroprotective effect was smaller. Unfortunately, polymer coatings on the metallic surface may exhibit numerous problems after implantation, such as late thrombosis, inflammation, and restenosis.

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The 9-year-old boy with connatal HIV infection presented with failure to thrive, chronic diarrhea, and intermittent abdominal pain. Assessment of Root Perforation within Simulated Internal Resorption Cavities Using Cone-beam Computed Tomography. Additionally, a corrective lenses group, 60 cases (120 eyes), was set up as the control.

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Biological sources of H2 include oxygenic photosynthetic green algae and cyanobacteria, both of which contain hydrogenase enzymes. Imatinib induced G0-G1 cell cycle block in CML cells, which was further enhanced in a mesenchymal stem cell (MSC) coculture system. Wild type C6 cells treated with ACNU (0, 10, 30, 60 micrograms ml-1) for one hour showed longer distance of migration of DNA than the ACNU-resistant subtype cells (C6R), indicating that ACNU-sensitive C6 cells were more vulnerable to ACNU than C6R cells.

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We also observed the vertical transmission of the bacterium to their progeny. Steady state levels of GIP mRNA were determined in the intestine during fetal and postnatal development by double ribonuclease protection assays.

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In the present study the ability of the nonenzymatic product of PGD(2), 15-deoxy-Delta12,14-prostaglandin J(2) (15d-PGJ(2)), to increase the cytotoxicity of allyl alcohol was evaluated. The lack of germline mutation in two members of another HPRT family and duplication of the same parental allele of chromosome 7 in multiple tumours suggests that a germ line event other than mutation of MET tyrosine kinase is involved in the development of these tumours. The reference signal was a 200-ms, 1000-Hz sinusoid, presented monaurally with the masker. The Peninsula Maternity and Neonatal Service (PMNS) was established on 1 January 1980 as a result of the regionalization of obstetric and neonatal services in the Cape Peninsula. The first- and second-order temporal interference between thermal and laser light.

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Differential diagnosis of shoulder pain: chronic neuropathy of the suprascapular nerve These findings suggest the possibility that PGE2 regulates PAK activity in PBL by inhibiting the production of IL-2 by activated T cells. A desorption-resistant fraction of adsorbed 2,4-D was estimated from interdependent adsorption and desorption isotherms. Determination of the heat and temperature of fusion of the absorbed water allowed resolution of the water into four different states.

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In addition, it was found that an A to C transversion in the first base following the initiation codon (in the absence of the inhibitory secondary structure) decreases lacZ expression almost twofold, whereas C to U transitions in the next two positions have negligible effects. Neural activity in primate parietal area 7a related to spatial analysis of visual mazes. To analyze the transition profile in more detail, we investigated local structural changes using temperature-dependent NOE intensities. Alternate-day treatment lacked all these adverse effects of betamethasone and the results did not differ significantly from those in the control chicks. Cystic fibrosis: the nurse-teacher and carer for mother and child.

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New anthracycline antibiotics produced by interspecific recombinants of streptomycetes. Joint inflammations and flare-up reactions in mice induced by a helper T cell clone. In this study, we further test the effects of SsaI on modifying the metastatic and invasive behaviors of cancer cell lines.

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It is suggested that the higher K1 value, representing an immediate effect of reserpine, stands for inhibition of uptake at the cell membrane. The biological basis of this heterogeneity is poorly understood. This review presents evidence that individuals with asthma are more susceptible to adverse respiratory effects from ozone exposure than are nonasthmatic individuals under similar circumstances. While progress in this field has been buoyed by the proposed existence of progenitor cells for the corneal endothelium at the corneal limbus, strategies for exploiting this concept remain unclear.

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The results seemed to confirm that the alteration of dental occlusion can induce some fluctuations in visual focusing. The postoperative images were compared with the intraoperative fluoroscopic images in terms of quality. Identification of patients with poor QoL during induction will provide opportunities for early interventions, and may subsequently improve future QoL. On caesarean delivery, fundal rupture of the uterus was identified.

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Specific profiles of change in T25FW and MSIS seemed to exist (generally, a lower increase in disease impact in patients with longer disease duration and higher baseline impact/disability). After an interval of at least two years 16 patients with paroxysmal postural vertigo were symptom-free 39 had rare or (and) tolerable vertigo, 30 frequent and (or) disturbing recurrent postural vertigo. The examination included a fasting blood sample, standard 2-h 75-g oral glucose tolerance test, blood pressure measurements and questionnaires to assess treatment for dyslipidaemia and hypertension.

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epidermoid carcinoma, A-431) are also TNF resistant, whereas those that express no significant levels of this gene (e.g. The patients who underwent implantation operations were studied by CT 3D and 99m Tc SPECT (Single Photon Emission Computerized Tomography) procedures to evaluate osseo-integration at 3 weeks, 3, 6, 12, 24 months. Some histamine H1 (tripelennamine, diphenhydramine and cyclizine) and H2 (ranitidine and cimetidine) antagonists (1 and 10 mg/kg) were administered to morphine-dependent mice to evaluate the changes on naloxone-induced abstinence syndrome.

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Effects of varying explantations given for a provocation on subsequent hostility. DNA fingerprints obtained from rep-PCR of extracted genomic DNA or from preparations of whole cells yielded comparable patterns.

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55,000-dalton, retrovirus-associated, cell membrane glycoprotein: purification and quantitative measurements of expression in viruses, cells, and tissues. Histopathological studies were carried out to determine whether or not an immunological reaction was involved in the treatment of cervical carcinoma. The aim of this study was to evaluate the effect of OD 14 on apolipoprotein A1 (Apo-A1), the major protein constituent of the high-density lipoprotein (HDL) fraction, as compared with that of oestradiol valerate (E2V) and a placebo. In recent years, the application of next-generation sequencing and other high-throughput technologies to analysis of pediatric brain tumors has generated an abundance of molecular information. Furthermore, pectic substances, including those purified from Gymnema sylvestre, inhibited histamine release from isolated rat peritoneal mast cells, which had been induced by the antigen.

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Our results show that this protein is endowed with antinociceptive activity. The cDNA coding for mature human alpha 1-proteinase inhibitor (alpha 1-PI) has been inserted into a variety of yeast expression vectors. Careful determination of early phase filling is important when seeking to acquire reliable urodynamic data on neurogenic bladders. Hyperthermia in the chick embryo: HSP and possible mechanisms of developmental defects.

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The overall results support the notion that in old age, increased proliferation of committed granulopoietic stem cells in hypoplastic areas of the BM, assure normal numbers of mature blood cells in the periphery. Postop: post-operative, Preop: pre-operative,SGOT(AST): serum glutamic oxaloacetic transaminase,SGPT(ALT): serum glutamate-pyruvate transaminase, CRP:C- Reactive protein, MDA: Malondialdehyde, DAS: Garlicextract diallyl sulfide, AGE: aged garlic extract. Sublethal oxidative stress dose-dependently inhibited RPE cell phagocytosis of photoreceptor outer segments (POS) and activated AMP-activated protein kinase (AMPK) as determined by increased Thr172 and Ser79 phosphorylation of AMPKalpha and its substrate acetyl-CoA carboxylase, respectively. We measured BMC for the total body, lumbar spine, proximal femur (and femoral neck and trochanteric subregions), and lean and fat mass by dual-energy radiograph absorptiometry (Hologic QDR 4500), and height, sitting height, leg length, and weight at baseline and 20 months. During the inflammatory reaction, shear stress in retinal veins is reduced 24 h before leukocyte infiltration.

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Assessment of parental knowledge and attitudes toward pediatric sports-related concussions. It could also have resulted from the greater nameability of colours made possible by combining hue and saturation cues systematically. Through multiple techniques and structural insights, we clearly demonstrate for the first time that human PDZ domain interacts with the predicted Short Linear Sequence Motif (SLIM) at the C-termini of the client proteins.

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Cellular proteins which bind to adenovirus type 2 and 4 origins of replication have also been fractionated from nuclear extracts of uninfected HeLa cells. Interleukin-1 is an astroglial growth factor in the developing brain. Prior treatment of pemphigus IgG organ cultured skin sections with unlabeled anti-C3, blocked positive C3 staining.

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It is now possible to map the human genome completely with a set of closely linked markers. This drug did not decrease the size of the prostate in normal intact animals and did not exhibit significant antiandrogenic activity. Isolation and characteristics of the messenger RNA of an interferon repressor To assess the morbidity of laparoscopic cholecystectomy since its introduction in Norway in the Autumn of 1990. Effects of genetically engineered microorganisms on microbial populations and processes in natural habitats.

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Tissue shrinkage accompanying dehydration of the specimen for scanning electron microscope study although a disadvantage occasionally proved useful in that it provided the opportunity to study the internal surface of the fibrous coating when separated from the surface of the implant. From a group of more than 200 patients with median and ulnar nerve compression syndrome three cases of interest are demonstrated in detail. Self-association and base pairing of guanosine, cytidine, adenosine, and uridine in dimethyl sulfoxide solution measured by 15N nuclear magnetic resonance spectroscopy.

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In this paper we describe a new monoclonal antibody, ZB51, which recognizes an intracellular antigen in normal plasma cells in cryostat tissue sections and cell smears, and which also reacts with neoplastic cells in most cases of myeloma and with plasma cell lines. However, the nuclear envelope protein maintains its localization even after nucleic acids are lost and the nuclear space is detectable in cornified cells by use of autoantibody directed to this protein(s). During this period (75--360 days) the activity of hexokinase declines about 5-fold, that of lactate dehydrogenase increases 2-fold, while phosphofructokinase activity is unchanged. TEN showed higher peak bone and implant stresses, and is more likely to fail in both loading configurations compared with the reconstruction plate. At zero surface pressure, there is a slow transformation of the closed bilayered structure into a lipid monolayer.

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Dental education for care of the disabled at the University of Washington. The structural basis of sequence-independent peptide binding by OppA protein.

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