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In cancer cells, both classes suppress microtubule dynamics through inhibition of microtubule dynamic instability and treadmilling, and commonly induce diverse signals responsible for cell death initiation and execution via the mitochondrial intrinsic pathway. The reduction of CR1 was dependent on the dose of IFN-gamma used and the time of cellular exposure.

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Regression in autism: prevalence and associated factors in the CHARGE Study. Low molecular weight heparinoids (LMWHs) offer a new treatment option to patients experiencing acute ischemic stroke. Iodoacetic acid-induced rigor in ileal longitudinal smooth muscle of guinea-pig. Characterisation of a novel lyssavirus isolated from Pteropid bats in Australia.

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As documented in several recent investigations, genital chlamydial infections are at least as common as gonorrhea in the Scandinavian countries. Normal rats, rats with chronic pancreatitis induced 12 to 16 weeks earlier by oleic acid injection into the pancreatic ducts, and sham-operated rats were studied. The variation in the FiO2 during normal and deep breathing was also studied in order to assess whether a significant difference in the FiO2 occurred.

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Several splints are being used, both dynamic and static, for the purpose of increasing finger flexion. MMC, however, showed a decreased cytotoxicity in XEM2 cells when compared to the parental V79 cells. When treated with the microtubule inhibitor colcemid, and fertilised, young eggs remained at metaphase, but many older eggs formed nuclei, although older eggs treated with colcemid and A23187 remained at metaphase. Personal toilet after defaecation and the degree of hand contamination according to different methods used.

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These results suggest that calcific valvar disease may result in part from vitamin K-dependent processes. (TWHF), has been shown to exert various pharmacological effects.

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For increasing the natural defence, RD-LPS as immunomodulator may be of practical value. Bacteriorhodopsin in dimyristoylphosphatidylcholine vesicles is randomly distributed in the plane of the membrane and exhibits rotational diffusion above the gel to liquid-crystalline phase transition. Following trypsin cleavage of the methyltransferase, a stable proteolytic product is produced which has been purified for biochemical characterisation. The development of the SisterTalk program could provide a useful starting point for development of successful weight control programs for black women in other parts of the United States as well as for other ethnic and racial groups. Mean survival after diagnosis in 73 patients with cancer of the pancreas was 7.2 months.

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Immunochemical demonstration of keratin and vimentin in cytologic aspirates. SP tests and a control test with normal saline were randomly performed at weekly intervals. On tractography, both groups A and B (with or without neurological deficit) showed disruption of fiber tract at SOL and thickness of distally traced spinal cord was appreciably less than the upper cord.

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Heterotopic ossification is a common complication of hip surgery and musculoskeletal or brain trauma. To study the association between serum human papillomavirus (HPV) deoxyribonucleic acid (DNA) and clinicopathologic prognostic factors and the clinical usefulness of serum HPV DNA in early-stage cervical cancer. The effect of phacoemulsification on corneal endothelial cell density. It was found, that is possible to identify most if not all the segmental arteries in the anteroposterior view, but the lateral view let identify the segmental arteries that arise perpendicular to the frontalplane. If validated in additional studies it seems rational to recommend to look for the GREM1 founder mutation in Ashkenazi individuals with multiple colorectal polyps and/or fulfill the criteria for LS.

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A small subpopulation of human peripheral blood T lymphocytes has the capacity to adhere selectively to myelinated sections of human and nonhuman brain tissue. The clinical presentation, investigation and treatment of these patients is discussed. This study demonstrates that both the clinical and electroencephalographic aspects of partial complex seizures in children are similar to those reported in adults. Although it has been inferred from recent studies in several model plant species that multiple photoreceptor systems mediate this process, surprisingly little is known of light signal transduction in maize. Report of a rare case with coincident occurrence of multiple oral polyps.

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Hierarchical regressions predicted each adiposity measure adjusting for age, race, gender, family socioeconomic status, and parental smoking. The primary aims of surgery are to maintain standing balance and prolong independent ambulation.

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The role of cell type in transport and metabolic conversion of antiviral substances. Functional Rho is required for signaling to SRF by several stimuli, but not by activated CDC42Hs or Rac1. The fatty acid composition of total lipids and total phospholipids of maxillae and mandibles of rats fed an essential fatty acid-deficient (EFAD), marginally FAD (MEFAD), and a control diet was determined. A week after neonatal sciatic nerve section, thiamine monophosphate-containing nerve terminals from nearby intact nerves begin to sprout into the sciatic nerve territory in the dorsal horn. Clinico-morphologic characteristics of the shock lung syndrome among patients sustaining hemorrhagic shock during labor

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Multiple and complex pathophysiologic abnormalities have been described in borderline hypertension. Wound healing and transwell experiments were used to evaluate cell migration and invasion. The organization of a multicenter approach will guide us towards a better understanding of ILD in children. The treatment of myofascial pain-dysfunction syndrome using the biofeedback principle. The N-terminal end of Spx contains a Cys-X-X-Cys (CXXC) motif, which is a likely target for redox-sensitive control.

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Nonetheless, all macroscopic, histologic, and biochemical cartilage parameters demonstrated adverse changes in chondrocyte activity and matrix integrity. The three cell lines were found to express both GD3 and gangliosides recognised by the A2B5 antibody. These findings provide new insight into the functional and neural dynamics of sensory suppression and suggest the existence of comparable agency mechanisms for both the upper and the lower limbs. Quantitative measures of BPE and FGT are different before and after RRSO, and their relative changes are associated with prediction of developing breast cancer, potentially indicative of women who are more susceptible to develop breast cancer after RRSO in BRCA1/2 mutation carriers.

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The vitamin E deficiency is thought to be due to abnormally accelerated utilization, excretion, or degradation of the vitamin. The peak of exopolysaccharide matrix (EPS) formation, that is formed in the process of biofilm formation, by museum strain takes place at earlier terms of cultivation (120 hours) than circulating (720 hours). The patient gradually recovered and was discharged after 58 days.

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The MF was found to be a protein capable of eliciting a proliferative response in normal human lymphocytes within 40-46 hours. These findings indicate that a product of arachidonate lipoxygenase is important in the sequence of events underlying cell activation for the production of human LP/LAF/IL-1. Molecular characterization of 7 patients affected by dys- or hypo-dysfibrinogenemia: Identification of a novel mutation in the fibrinogen Bbeta chain causing a gain of glycosylation. A 48-year-old woman developed symptoms related to a tumour attached to the outflow tract of the right ventricle. Assessment of the in vivo response to multiple minor antigens in delayed-type hypersensitivity responses and in priming for subsequent mixed lymphocyte culture generation of lymphocyte-mediated cytotoxicity revealed a major degree of cross-reactivity for antigens not present on the initial in vivo stimulus.

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Calcineurin-induced energy wasting in a transgenic mouse model of heart failure. The initial AaDO2 were similar in both the groups but on day 3, 4, 5 AaDO2 were low in study group (201, 85, 70) compared to control group (236, 209, 162).

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Here, we investigated the effects of three types of anesthetics commonly used for animal experiments (urethane, pentobarbital and ketamine/xylazine). This study investigated the possible modulation by cAMP-mediated mechanisms, of cellular transit of newly-synthesised caseins and their basal secretion in explants of mammary tissue from lactating rats and rabbits. For example, improved treatment of affected individuals in dominant and X-linked diseases could lead to improved reproductive fitness, higher gene frequencies, and to an increased incidence in future generations. Nocturnal home oximetry in detecting the sleep apnea-hypopnea syndrome and in working up hypersomnolence. They were asked about advice given to patients regarding length of time to refrain from nose blowing and air travel following treatment of zygomatic fractures.

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Understanding and practice of evidence based search strategy among postgraduate dental students: a preliminary study. Our study reveals an active regulation, rather than passive inhibition, of CDK4 activity during adipocyte differentiation. The selective gains on the semantic and phonological measures suggest that improved verbal communication was achieved in a different way for each treatment group. In all conditions tested, ie, ascitic and disseminated L1210 leukemia, ascitic LSTRA lymphoma, and advanced Lewis lung carcinoma, AD 32 was significantly more effective in terms of lifespan prolongation and induction of cures than optimal adriamycin treatments.

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The present contribution using model systems indicates the usefulness of re-alignment procedures for correcting non-stationary characteristics, prior to self-modeling curve resolution (SMCR), and the potential for investigating more complex problems. In humans, TBX1 is implicated in the etiology of the DiGeorge syndrome. arizonae, the Adh gene has duplicated, giving rise to a larval/ovarian form (Adh-1) and an adult form (Adh-2). The authors describe a patient who developed a wide complex tachycardia developing during stress testing while on therapy with flecainide, and the difficulty in interpreting the electrocardiogram. Right upper extremity venous thrombosis following placement of dual-chamber urethane pacing lead.

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Gas exchange during ventilator treatment: a validation of a computerized technique and its comparison with the Douglas bag method. Further analysis, however, suggests that increased cortical venous pressure reflects the effect of the failure of transvillus absorption with increase in CSF pressure on the venous pressure gradient between ventricle and cortex. The exercise electrocardiogram after the acute phase of myocardial infection.

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In addition ProteINSIDE is the only resource that predicts proteins secreted by cellular processes that do not involve a signal peptide. Putative differences in the latter were expected to point to changes in the processing associated with neural pathways or cortical regions in the older subjects. Production of a large quantity of big ET-1 by the method described here is expected to facilitate future experiments such as X-ray crystallography and nuclear magnetic resonance studies, aimed at understanding the tertiary structure of big ET-1 and its dynamics. A case of complete posterior displacement of a Salter-Harris Type III distal medial femoral epiphysis fracture with posterior subluxation of the knee is reported.

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infusions produced a pattern of melatonin in the blood equivalent in amplitude and duration to that observed previously in pineal-intact animals exposed to a short photoperiod. The patient who has symptomatic coronary artery disease suffers from a chronic, incurable illness. We suggest that, after As(2)O(3 )treatment, the N-terminal domain of c-Jun phosphorylation by JNK recruits TGIF/HDAC1 to the Sp1 sites and then represses p21 expression. In addition the human enzyme has three more residues at the C-terminus.

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pomifera agglutinin, three more beta-chain forms were found, but all six could arise from only two genes, with additional post-translational proteolysis and post-translational substitution with an unidentified component of 106 Da creating the set of six forms. The OAEs recorded with the contralateral tone were compared with those recorded without the tone to determine the effect of the acoustic reflex. Exaprolol, metipranolol and propranolol significantly modulated 32P incorporation into phospholipids of resting and 48/80 stimulated cells.

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Notes on the early history of infective endocarditis and the development of an experimental model. In this article, we present the major findings regarding the health status of the Dutch population and discuss the implications for prevention policy. This high expression was decreased with the development of HCCs.

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Histological and biochemical investigations confirmed an acid maltase deficiency (AMD). Intersubject variability elucidates the cerebral generators and psychological correlates of ERPs. The target antigens recognized by the cross-reactive population of cytotoxic T cells on A/USSR/90/77 (H1N1) influenza virus-infected cells was studied with monoclonal antibodies to the H-2k antigen and viral hemagglutinin. A common mechanism of chromosomal translocation in T- and B-cell neoplasia. On the base of the results obtained it is suggested that, contrary to this norm, it is more favourably not to use the preincubation for the detection of staphylococci in feed mixtures because the MPN of staphylococci found by statistical analysis in 1 g of the preincubated mixture is significantly lower than that obtained without preincubation.

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In summary, we have developed an epitope-tagged Cre recombinase that is fully active and readily detectable. A new dwarfism of a spondyloepiphysometaphyseal dysplasia is described among Venezuelan Indians of the Yukpa (Irapa) tribe. Photoluminescence of a single quantum emitter in a strongly inhomogeneous chemical environment.

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Past studied have not revealed useful correlations between clinical variables and the energy required to terminate ventricular fibrillation. After the successful completion of experiments with animals, 7 patients with portal hypertension were implanted with porta caval interposition grafts, using 12 mm gauge, 3-4 cm long, Dacron double velour. For future research, we suggest greater methodological rigour (participant selection, blinding of outcome assessors, reporting of all outcomes analysed and registering of the study protocol). The hypothesis was also tested in endothelial cells, a more physiological system, where both proteins are naturally expressed. Administration of RMI 12,936 on Day 1 of pregnancy caused acceleration of egg transport, the initial changes being apparent within 12 hr of dosing.

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Antibodies against orthopoxviruses in wild carnivores from Fennoscandia. An online cross-sectional survey was conducted via public bulletin boards and invitational e-mails.

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The level of IS substance increased in accordance with advance of cancer, showing the highest level in advanced and recurrent cancer patients. Future directions in the treatment of non-small cell lung cancer. Oculomotor disorder, paralysis of all extremities and consciousness disorder (angiography of the vertebral artery): (thrombosis of the basilar artery) Changes in nitric oxide precursor, L-arginine, and metabolites, nitrate and nitrite, with aging. To investigate the influence of calcium ions on the secretion of anterior pituitary hormones in response to stimulation by exogenous hypothalmic releasing factors in man, we measured serum concentrations of pituitary hormones serially during a continuous infusion of combined TRH (2 micrograms/min) and GnRH (1 microgram/min), with concomitant iv saline or calcium administration.

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Linear growth retardation in relation to the three phases of growth. Inhibition of protein kinase A fails to alter mast cell adenosine responsiveness. In future new MRA techniques may be useful in postoperative staging of patients with peripheral vascular stenosis. Omental infarction is a benign self-limited disease that can mimic acute abdomen.

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All in all, histologic considerations suggest that asthmatic patients with severe sinonasal polyposis might benefit from the C-L procedure. First isolations of Levinea-Citrobacter cultures in Czechoslovakia. Relationship between perceived exertion and blood lactate concentrations during incremental running test in young females. Glucocorticoids in the prevention of respiratory distress syndrome The subjects were randomized to treatment with low-dose continuous combined HRT containing 1 mg 17beta-estradiol plus 0.5 mg norethisterone acetate (Activelle) or a sequential combined HRT regimen consisting of 0.625 mg conjugated equine estrogens for 28 days plus 5 mg medrogestone for 14 days (Presomen).

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This study was conducted to clarify the development of free neuromasts with growth of the barramundi, Lates calcarifer. Specific initiation by polymerase I decreases in high-density cultures, paralleling the decrease in abundance of the endogenous 35S rRNA precursor.

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One dynamic system is the transcriptome which comprises a variety of RNA species. Principal components analysis was also applied to the liver curves producing two relevant components. Comparison with human and mouse pancreatic and salivary alpha-amylases and with rat pancreatic amylase obtained from the corresponding cDNA nucleotidic sequences shows a high degree of homology between mammalian alpha-amylases. Increasing the external K concentration reduced both the amplitude of the voltage response and the rise time.

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Ocular pathology should be considered in the evaluation of psychotic states in the elderly. Cardiopulmonary bypass can be used to establish a resuscitation model in rabbits. Rotavirus infection causes acute gastroenteritis with diarrhea and dehydration of various degrees resulting primarily from destruction of intestinal villus enterocytes with subsequent impairment of the ion transport and absorption. We applied a questionnaire, and performed skin prick testing and pulmonary investigations in 36 workers at two herring factories, using 31 municipal workers as controls.

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Clinical outcome of long-term management of patients with vitamin B12-unresponsive methylmalonic acidemia. Sixteen women had preeclampsia develop at a later stage of pregnancy (preeclamptics), whereas 89 women continued to have normotensive pregnancies until delivery. Effectiveness measures, including survival to discharge, discharge medications and 30-day MACE, demonstrated improvement or favorable trends. We show that the DNA frame and one set of nanoparticles can be used to create nanoclusters with different chiroptical activities. In normal UPJ specimens there were many c-Kit positive ICCs between the muscle bundles.

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At 1, 3, and 6 days after feeding, bacteria were isolated from insect guts and feces. Homologous interference was elicited by interferon-producing live or UV-inactivated strains and non-interferon-producing live or beta-propiolactone-inactivated strains and it was not influenced by actinomycin D.

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MAb 5A10 can serve as a cell-specific marker of the bipolar cells. We observed the antifungal activity of HE against 125 vaginal yeasts that belonged to four different species of the Candida genus and S. Although the data were compatible with T cells as the source of effector cells in the virus-specific CMC, definitive identification could not be made. In addition, M2 receptor binding was also reduced in the basal ganglia, CA3 field of the hippocampus, deeper layers of cortex, medial and central nuclei of amygdala, and thalamic nuclei. Treatment of both intact and hypophysectomized pregnant rats on days 19 and 20 of pregnancy with PGF2alpha results in a rapid fall in plasma progesterone concentrations by day 20 followed by premature delivery on day 21.

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Oncofetal (OF) antigens have been isolated from mouse F9 teratocarcinoma cells, mouse testicular cells, and human molar tissue by detergent extraction followed by dialysis. With isoelectric focusing and with starch gel electrophoresis it could be shown that virtually all protoporphyrin in the erythrocytes is protein-bound. Automated amino acid sequence of small peptides utilizing Polybrene. Proceedings: Thromboembolic complications after aortic valve replacement: comparative study. The adhesion of canine platelets and leucocytes was tested by passing whole blood from the anaesthetized mongrel dog in an ex-vivo shunt system.

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The regulatory region of the barnase gene, however, is quite different from the other two. Acoustic characterization following pathologic evaluation demonstrated certain echogenic features to be highly suggestive of benign disease. Risk factor analysis was performed in 184 children and an equal number of matched controls. jellisoni could be used in the Sabin-Feldman dye test to determine the development of antibody to B. Multipoint linkage analysis gives a lod score of 9.94 for a location between D9S43 and D9S50.

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In keeping with previous findings dextroamphetamine administration decreased regional brain activation in all three tasks. Correlations between lactic acid and haemoglobin content, between rectal temperature and Hb, and between lactic acid and changes in rectal temperature were discussed. Most human chromosomes have been mapped, with markers in defined order placed approximately 10 map units apart.

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Comparison of morphine and butorphanol as pre-anaesthetic agents in combination with romifidine for field castration in ponies. Scoliosis in multicore disease may take a rapidly progredient course. VCAM-1 is an important adhesion molecule that is expressed on endothelial cells and has a critical role in endothelial activation, inflammation, lymphatic pathophysiology, and atherogenesis. The mean follow-up time was 49.3 months, ranging from 23 to 69 months. Twenty-six patients (15 men and 11 women) completed the study and among these 15 had been depressed for more than 10 years and 19 showed an entry total score of more than 25 points on the Hamilton Rating Scale for Depression (17 items).

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Dissection of the 66 000-dalton subunit of the acetylcholine receptor. The combination of ASCs and PRP appears to be synergistic, and the addition of BMP-2 could further improve the results. A detailed description is given of a method to section the pituitary stalk of the fetal lamb after 105 days gestational age.