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Lamivudina (Lamivudine)
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Lamivudine

Lamivudina is a synthetic nucleoside analogue with activity against hepatitis B virus (HBV) and HIV. Intracellularly, Lamivudina is phosphorylated to its active metabolites, lamiduvine triphosphate (L-TP) and lamiduvine monophosphate (L-MP). In HIV, L-TP inhibits HIV-1 reverse transcriptase (RT) via DNA chain termination after incorporation of the nucleoside analogue into viral DNA. In HBV, incorporation of L-MP into viral DNA by HBV polymerase results in DNA chain termination. L-TP is a weak inhibitor of mammalian DNA polymerases alpha and beta, and mitochondrial DNA polymerase. Check for active clinical trials using this agent.

Other names for this medication:
Lamivudine, Epivir, Heptovir, Lamivudina, Lamzid, Zeffix,

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Emotion as personal creation: a psychoanalytic and psychological perspective. HRAS is silenced by two neighboring G-quadruplexes and activated by MAZ, a zinc-finger transcription factor with DNA unfolding property. This investigation was conducted as a cohort study in which 59 patients with type-2 diabetes participated.

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The cone dystrophy may be caused by a rearrangement of the X-chromosome pigment gene array that is associated with the deletion of L-cone sequences and the formation of hybrid L-M cone pigment genes. An identical conclusion is also reached for the bovine papillomavirus type 1 E2 protein.

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Sel-Plex may represent an excellent Se supplement to deliver a high level of Se without provoking harm to the fish and to guarantee the maximal absorption of the element. Placental chorioangioma, an unusual cause of polyhydramnios: antenatal diagnosis.

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Alpha taxonomy of the genus Kessleria Nowicki, 1864, revisited in light of DNA-barcoding (Lepidoptera, Yponomeutidae). Light and electron microscopy observations in the thyroid gland of the pheasant (Phasianus colchicus L.). The plasma disposition of rhodamine-123 was unchanged by cyclosporin A, indicating that the change in brain exposure was mediated by a process at the level of the blood-brain barrier, possibly by inhibition of the p-glycoprotein efflux transporter.

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Anticancer activity of Cinnamon tamala leaf constituents towards human ovarian cancer cells. Simultaneous occurrence of oral lichen, psoriasis and ulcerative colitis Given the high prevalence of excessive and episodic heavy drinking and the impact of alcohol on energy intake in this population, national surveillance programs and targeted prevention interventions for problem drinking in the U.S. Apigenin, a common plant food flavonoid, was shown to modulate the nuclear translocation of SREBP-2 in the hepatic cells WRL-68 in the present study.

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According to each of five clinico-prognostical groups established, basing on a PI value, the therapeutical management is conducted. The rehabilitation program resulted in a decrease of the range of sways, improved visuomotor coordination and thus also improved balance.

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Measurements of radiation level in petroleum products and wastes in Riyadh City Refinery. Denitrification is an alternative form of respiration in which bacteria sequentially reduce nitrate or nitrite to nitrogen gas by the intermediates nitric oxide and nitrous oxide when oxygen concentrations are limiting. In 68 patients, subxiphoidal, percordial, and suprasternal echocardiography was used to trace the Swan-Ganz catheter during its passage to the pulmonary artery and to localize its position. PD98059, which is a selective ERK inhibitor, significantly inhibited estrogen-induced cell proliferation.

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This apparently successful management of suppurative ear chondritis by employing antibiotic iontophoresis does suggest a clinical potential for the use of the procedure. Cornea plana congenita gene assigned to the long arm of chromosome 12 by linkage analysis.

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In the present paper, the authors review the methodological bases of surveys, both descriptive and analytical, used in animal epidemiology. It is found, however, that while less time and energy is devoted to play, the pattern of play that does occur is similar to that of healthier peasant children in other times and places. The extent of bacterial adherence depended on the state of differentiation of the target cell in both the isolated and the cultured ruminal cell systems. Perspectives for nursing and goals of the National League for nursing 1979-1981. Isolation and characterization of gmsti, a stress-inducible gene from soybean (Glycine max) coding for a protein belonging to the TPR (tetratricopeptide repeats) family.

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In acidic medium supplemented with either Casamino Acids or glucose, the wild-type allele conferred a slight advantage. L-Dopa has has been shown to demonstrate enhanced toxicity toward melanoma cells in vitro. The two major outcome trials on the combination of angiotensin-converting enzyme (ACE) inhibitors and mineralocorticoid receptor (MR) antagonists in heart failure are RALES (Randomized Aldactone Evaluation Study) and EPHESUS (Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study). IL-10 has a variety of effects including: inhibition of monocyte MHC class II-dependent Ag presentation, Th1 cytokine production, and inhibition of T cell proliferation.

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Sterols prevent transcriptional activation by blocking the proteolytic cleavage. Regular feedback of these data to the veterinary practitioners and consultation about the efficacy of the formulary guidelines in daily practise. Employing the oxidative coupling of phenylacetylene with benzaldehyde as a model reaction, a density functional theory (DFT) study combined with extended X-ray absorption fine structure (EXAFS) experiment was carried out to reveal the difference between dinuclear and mononuclear zinc mediated nucleophilic addition. Catalytic hydrogenation of the double bonds was performed and the methyl ester trimethylsilyl, methyl ester allyldimethylsilyl and methyl ester tert-butyldimethylsilyl ether derivatives of the reduced compounds were prepared. After acute cold exposure plasma NEFA level was low in cold-acclimated rats and high in NA plus T4-treated rats.

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To document the manifestations of syphilis among patients with concurrent HIV infection over a 12-month period. Such integration allows for fully graphical and interactive process of modeling, from building the network to simulation of the finished model. Early and late efficacy of three types of transvenous atrial leads.

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Review of the National Qualification Examination for nursing licenses. The LP NMuMG cells had a typical epithelial morphology and showed no cytologic evidence of cancer. We demonstrate four cases of cortical and medullary nc of different etiology.

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Hypnosis in pedodontics with particular reference to various induction technics To date, leading indicators of instability in systems with multiple interacting components have remained poorly investigated. Pieces of skin from 13-5- to 15-day-old foetal mice were grown in organ culture in a biological medium with or without the addition of hormonal steroidsmcortisol (7-5 mug/ml) caused thinning of the non-cornified epidermis and flattening of the stratum granulosum after 3 days.

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Pearls of wisdom for clinical teaching: expert educators reflect. We describe the clinical characteristics of 10 symptomatic former WTC workers diagnosed with this condition, as well as the frequency of spirometric findings suggestive of variable extrathoracic obstruction. Our results show no significant association with MS and no protective effect of T-1237C concerning age of onset, disease severity or disease subtype in MS patients. Elevated cathepsins levels and activities are found in several types of human cancer, making them valuable biomarkers for detection and targeting therapeutics. In addition to modulation of the innate immune response, a key function of microglia is the phagocytosis of dying cells and cellular debris, which can facilitate recovery.

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The policy of performing selective midline episiotomy in nulliparous patients results in a reduction in the risk of third-degree perineal lacerations. Total activity of phenylalanyl synthetase in progeria cells was similar to that of control cells at early passage while late-passage control cells had lower specific activities of these synthetases per unit protein. Immune cells, cytokines, and epigenetic factors have all been recently implicated in lupus nephritis pathogenesis. However, when blast cell colonies supported by interleukin 3 were replated into secondary dishes containing IL-6, they could differentiate into only neutrophils and macrophages. Co-administration of physostigmine (0.1 mg/kg, i.p.) and methysergide (10 mg/kg, i.p.) increased REM but blocked completely NREM sleep.

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Electrochemical synthesis, structural characterization, and decomposition of rhenium oxoethoxide, Re4O4(OEt)12. We extracted data on study design, population characteristics and outcomes related to influenza symptoms and antibody titres. injection of 20 mg of S-nitrosocysteine, a putative EDRF, caused BK-like responses. Inhibition of varicella-zoster virus glycoprotein expression by peripheral blood mononuclear cells. Dietary phytate also reduced the biological half-life of body 65Zn from 61 to 211 h post-administration, possibly by inhibiting reabsorption of endogenous 65Zn and thus promoting a more rapid loss from the body.

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The peritoneal fluid volume, macrophage concentration, macrophage content, and content of activated macrophages as measured by acid phosphatase staining were all significantly elevated in the endometriosis patients. Possibility of split-course radiotherapy in the treatment of advanced carcinoma of the oral cavity and the pharynx A new two-tier box trap designed for collecting Chrysops was tested on St.

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IMBF during the final rest was 1.7 times higher than the initial rest flow. Impaired myocardial function in spontaneously hypertensive rats with heart failure. These bands specifically stain with both pemphigus antiserum and the desmosome antiserum. In contrast to MS-1112 and Val, inhibitory action of Dexa was slow in onset after the topical application. Compared to the test norms for patients with diffuse cerebral lesions, the state of encephalopathy in patients with cirrhosis has a qualitatively different pattern of cerebral affection, since disturbances of attention were found independently of general intellectual function.

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The acute study revealed no lethal effects at 300mg/kg of HERP, but toxic signs were observed, as HERP had an LD50 of more than 300mg/kg, indicating a warning. Despite the obvious need for a shift from palliative treatment to prevention the establishment of quality standards for palliative chemotherapy remains a major goal. Extraction from freeze-dried and powdered material was more efficient but only satisfactory when partitioning in an aqueous polymer two-phase system was employed. As the velocity increased from 4 to 40 cm/sec at constant bluntness, the weight percent distributions shifted away from larger diameter particles. As in the homologous series of retinoic acid studies, compounds with side chains shorter than retinoic acid were not active while compounds with side chains as long or longer than retinoic acid were active.

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The two-jaw procedure was performed according to the virtual plan. The purpose of this study is to evaluate a series of operatively treated acetabular fractures with neurologic injury and to track sensory and motor recovery. According to the characteristics of these depressive illness, to the related locomotive state and to various monoamingeric hypothesises that are suggested both in the genesis of affective disorders and the mechanism of action of two biochemically related depressive aspects, a distinction already considered by other authors for endogeneous depressions.

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Neither CCK nor devazepide caused any changes of protein content:DNA content ratio during the study. Both the cis- and the trans-DDP cross-linked significant numbers of chromosomal non-histone proteins to the DNA. Comparison of placental volume in early pregnancy using multiplanar and VOCAL methods. These results suggest that inflammatory cytokines, excessively produced due to inflammatory reactions, stimulate as a mediator the release of arachidonic acid, increasing LTB4 production.

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Total unconjugated oestrogen and progesterone concentrations in peripheral blood during pregnancy in the dog. In France, vascular access thrombosis rate is low and not influenced by surveillance protocol type. Body reactivity characteristics of chronic salpingo-oophoritis patients at the health resort stage of rehabilitation The aim of this editorial was to discuss evidence indicating a role for low-grade inflammation as a pathogenetic event of the metabolic syndrome.

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A manic child should be treated using a biopsychosocial approach. To evaluate the role osteoinductive bone proteins may play in enhancing bone ingrowth, six canines had bilateral total hip arthroplasties with a cementless press-fit porous-coated acetabular component. ST segment response to acute coronary occlusion: coronary hemodynamic and angiographic determinants of direction of ST segment shift. Using an exogenous Smad-responsive transcriptional promoter reporter, we show that Smad activity is repressed by FGF-2, likely an effect of the fact that FGF-2 treatment prevents the nuclear localization of Smads in these cells. Properties of posterior composite: results of round robin testing for a specification.

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Although the mean values of the domain scores were not different, women did report differences in sexual functioning during vs. Analysis of the susceptibility of CD57 T cells to CD3-mediated apoptosis. Role of stimulus locale on strain differences in active avoidance after scopolamine of D-amphetamine treatment.

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Transcutaneous puncture drainage in suppurative destructive diseases of the perirenal cellular tissue A threefold increase in the acceptance rate occurred in people aged under 55 in both the black and Asian populations, suggesting that the higher rates are probably not due to factors related to access alone. A dose of 7.5 microgram PGF2 alpha was as effective as 15 microgram in inhibiting sexual receptivity, while a dose of 1.5 microgram was near the minimum effective level. Genes encoding carbapenemases and insertion sequence ISAba1 were screened via PCR sequencing.

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The permissive growth factors IL-11 and IL-9 seem to be able to partially counteract the negative regulation of TGF-beta 3. Hepatic endocytosis of various types of mannose-terminated albumins. Sex hormone receptors, prostaglandins and cAMP, in functional activity of the uterus

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To study the roles of Tyr-783 phosphorylation in vivo, we developed a polyclonal antibody that recognizes PLCgamma1 containing phosphotyrosine 783 (alpha-PLCgamma1 PY). Taste responses in the nucleus tractus solitarius of sodium-deprived rats. Results of sensitivity analyses suggest that probably only a small part of this international pattern can be attributed to differences between countries with respect to occupational classification. Nevertheless, the mean contrast-to-noise ratio of cord lesions was decreased on 3D driven-equilibrium fast spin echo sequences compared to 2D fast spin echo sequences.

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Although this study was not primarily designed to assess the role of surgical technique, phacoemulsification cataract extraction had a statistically significant protective effect against wound complications. Matchmaking and McNemar in the comparison of diagnostic modalities. The effect of Shigella sonnei strains opposite in their virulence on different links in the immune system Typically, the volume of sorbent that can be used repeatedly is between one quarter and one tenth of the sample volume to be treated.

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Uroflowmetry was between 7.5 and 17.6 ml/sec and residual urine appreciate by ultrasounds was less than 60 cm3. Several strains proved to be sensitive to the antimetabolites 5-fluorouracil and methotrexate as well as to doxorubicin and cis-platine. The results suggest that the adolescents had little knowledge of mental health services and they primarily discussed their problems with other family members or friends.

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Where this assumption is not met, treatment effect estimates will be biased. These 33 men were compared with matched controls for symptoms before the neoplasm was detected radiologically.

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Invasion of surrounding normal tissues is generally considered to be a key hallmark of malignant (as opposed to benign) tumors. Fixation and Wear With Contemporary Acetabular Components and Cross-Linked Polyethylene at 10-Years in Patients Aged 50 and Under. Rotation angioplasty--a new procedure for reopening and dilating blood vessels. The advent of small digital computers with analog-to-digital capability permits more efficient recording. After destroying peripheral adrenergic structures by 6-OH-DA a change from a two-compartment to a one-compartment model of AMPH kinetics occurred.

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These studies should clearly define the populations being studied, include large numbers of individuals and total populations, provide a clear definition of an ulcer, describe case identification procedures, and clinically confirm the presence of ulcers. Only phagocytic and Ia-positive accessory cells induced antigen specific Th cells. Phalangeal transfer for recurrent giant-cell tumor of the phalanx of a finger in a nine-year-old child. Epithelial cell adhesion molecule (EPCAM) and stage-specific embryonic antigen 1 (SSEA1) were upregulated early during reprogramming and enabled enrichment of OCT4 expressing cells by magnetic cell sorting. After stimulation of acinar cell secretion by isoproterenol, similar vacuoles were occasionally observed in both intercalated and striated duct cells.

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With the analog device the velocity is measured by tachometer and distance by potentiometer, while using digital methods, both parameters can be obtained from an optical transducer. This series of events frequently results in localized tissue damage.

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Mediation of subacute anthracycline cardiotoxicity in rabbits by cardiac histamine release. A comparative study of the metabolic effects of injectable and oral contraceptives. In 20 children, no significant change in GVR was observed after lengthening was carried out at a mean age of 9.6 years. Real-time polymerase chain reaction (PCR) analyses revealed that the expression levels of several stress-regulated genes were altered in AtGSTU19 OE plants.

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Temporal and spatial parameters of reaching and grasping were determined for each phase. If recognised in time and treated correctly the morbidity and mortality should not be influenced. Study casts on thirty-five partially edentulous patients were analysed at their arch level and at the interarch levels. Fatty streaks showed the highest concentration of 7 beta-hydroxycholesterol relative to cholesterol, and the lowest ratio of linoleate to oleate, suggesting that this type of lesion experiences the greatest concentration of free radical activity.

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To our knowledge, this is the first report on the use of a terazosin hcl cost sol-gel zirconia-based hybrid organic-inorganic coating as an extraction medium in solid phase microextraction (SPME). Patterns of glycine and taurine conjugation of bile acids in duodenal juice have been studied in 20 low birth weight babies at 12 and 22 days of age. A conserved proline-X-X repeat segment in the central core of the protein, which is reminiscent of an SH3-binding domain, is critical for the enhancement of infectivity function but is dispensable for CD4 downregulation.

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These findings suggest transposition of genes conferring trimethoprim cizole 20 mg omeprazole resistance from plasmids to the bacterial chromosome. Overlapping genes in mammalian genomes are unexpected phenomena even though hundreds of pairs of protein coding overlapping genes have been reported so far. Freeze-fracture study of the junctional complexes of human and rabbit thyroid follicles.

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Iodoacetic acid had no inhibitory effect on DNA synthesis in isolated nuclei but esperal drug abuse strongly inhibited DNA synthesis in intact cells. These epithelial cultures were neither tumorigenic nor did they display anchorage-independent growth.

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Type A, type B and type non-A, non-B hepatitis patients were followed up. Episome-generated N-myc trichopol 250 mg tablets antisense RNA restricts the differentiation potential of primitive neuroectodermal cell lines.

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In subjects with chronic obstructive pulmonary disease (COPD), the effect of partial pressure of CO2 (PaCO2) alterations during long-term non-invasive ventilation (NIV) on continuance remains uncertain. The question of how the plasticity of the infant visual cortex is compatible with the regular patterns of the adult visual cortex has been a central problem of the brain neuroscience. They are entirely consistent, however, with the ceprandal capsules for nespresso hypothesis that the negative feedback control of LH release by the male gonad is mediated, principally, via the central nervous system by an action of testicular hormone, most probably testosterone, to retard the frequency of the neural timing mechanism that governs the intermittent pattern of GnRH release by the hypothalamus.(ABSTRACT TRUNCATED AT 400 WORDS) The nerve and muscle grafts can be performed by microneurovascular anastomosis in one surgical procedure. A linker length of either six or 10 amino acids proved to have the largest thermally induced response.

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The present study was undertaken to review the experience at the Medical College of Virginia/Virginia Commonwealth University Temporomandibular Joint and Facial Pain Center with surgical management of intra-articular bactrim ds dosage meniscus dysfunction (IMD) as a specific entity. Here, we show that perforin is absent from a number of cell lines that nevertheless display vigorous cytolytic activity toward target cells. Proteins containing cysteine substitutions at positions 101 and 104 were able to form disulfide bonds spontaneously in crude extracts.

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The quad-helix was used for maxillary expansion, while utility arches were used for intrusion (group I) or protrusion and intrusion (group II) of the maxillary incisors. Furthermore, they have potential for drug testing and even future organ replacement strategies. The tests included tapping, force production, fexofenadine tablets ip 180 mg to ml tactile double simultaneous stimulation, pressure sensitivity, passive joint movement sense and sensitivity to hot and cold. Interactions of triazine herbicides with biochar: Steric and electronic effects.

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Her ocular history revealed an uneventful LASIK procedure 4 years previously with epithelial problems of the flap followed by S. To determine the clinical value of elastase alpha 1-proteinase inhibitor complexes (E-alpha 1 PI) in pleural effusions, fluid samples disulfiram dosage forms of spironolactone of 99 patients were examined.

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In our tenofovir disoproxil tablets model, striatal spiny neurons of the basal ganglia function in contextual pattern recognition under the training influence of reinforcement signals transmitted in dopamine fibers. The design is an observation study of prospectively collected data. However, their potential for use during anaesthesia, acute asthma, exacerbations of chronic airflow limitation, and in studies into the normal and abnormal mechanisms of ventilation during sleep has yet to be realized. Functional studies suggest that the quaternary structure of the oligomer is intermediary between R-and T-state.

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Both cell lines also form a mineralized sarcoma when implanted augmentin 250 mg syrup restaurant in rats. Here, we demonstrate that androgen-sensitive LNCaP human prostate cancer cells produce and secrete neurotensin following androgen withdrawal.

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The usefulness of needle biopsy in chest lesions of different sizes and locations. Superselective embolization and surgery of noninvoluting etaconil tab 250mg hemangiomas and A-V malformations. Comparative study of the sinus septa between dentulous and edentulous patients by cone beam computed tomography.