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Ketolef (Ketoconazole)

Ketolef is active against Candida spp., and Cryptococcus neoformans. However, its activity is limited compared to that of fluconazole and itraconazole. Furthermore, due to its limited penetration to cerebrospinal fluid, it is clinically ineffective in meningeal cryptococcosis. Its activity against the dimorphic moulds, Histoplasma capsulatum, Blastomyces dermatitidis, Coccidioides immitis, Sporothrix schenckii, Paracoccidioides brasiliensis, and Penicillium marneffei is favorable. However, fluconazole and itraconazole are at least as effective as Ketolef against these fungi and are safer. Thus, Ketolef remains as an alternative second-line drug for treatment of infections due to dimorphic fungi. Ketolef is not recommended for treatment of meningeal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides immitis due to its limited penetration to cerebrospinal fluid. Ketolef is also active against Pseudallescheria boydii and is a good alternative for treatment of pseudallescheriasis. It is also effective in pityriasis versicolor. Ketolef has practically no activity against Aspergillus spp., Fusarium spp., and zygomycetes order of fungi.

Other names for this medication:
Ketoconazole, Nizoral, Akorazol, Arcolan, Arcolane, Asquam, Biogel, Clarazole, Conazol, Daktagold, Daktarin, Dezor, Diazon, Dikoven, Eumicel, Extina, Funginoc, Fungoral, Ilgem, Kenazol, Kenazole, Ketazol, Ketokonazol, Ketolef, Ketovid, Ketozal, Liondox, Lizovag, Micoral, Micosin, Muzoral, Mycoderm, Noell, Orifungal, Oronazol, Panfungol, Perative, Phytoral, Pristinex, Tiniazol, Tinuvin, Xolegel, Yucomy, Zoloral,

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Monoclonal antibodies point to carbohydrate structures as tumour-associated antigens. Although a considerable number of grade 1 and 2 cases in both systems had PNM, fulfilling the criteria for grades 1 and 2 CNFS, it does not perfectly predict PNM. Letter: Hypoglycaemia in children undergoing adenotonsillectomy.

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Fracture union in closed interlocking nail in humeral shaft fractures. Blinding eye diseases caused by neovascularization of the retinal tissue are the leading cause of blindness in Western societies. Notably spermatogonia, capillary endothelium, connective tissue and peritubular fibroblasts are rarely involved. The role of alpha- and beta-adrenoceptor subtypes in mediating the effects of catecholamines on fasting glucose and insulin concentrations in the rat. Common afflictions diagnosed by arthroscopy include chondromalacia, meniscal lesions, osteoarthritis, cruciate ligament injuries, chronic synovitis and loose bodies.

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Oligonucleotide primers, based on the published amoA sequence from Nitrosomonas europaea, were used to amplify DNA from pure cultures of Nitrosomonas europaea, Nitrosomonas cryotolerans, and Nitrosococcus oceanus and from bacteria in seawater collected offshore near the Florida Keys. A cluster of genes involved in polysaccharide biosynthesis from Enterococcus faecalis OG1RF. ICI 182,780 eliminated the effects of estrogen on brain edema and brain blood barrier permeability. Tissue homogenates and bronchoalveolar lavage fluid from patients with IPF both demonstrate elevated IRAP content compared with that in normal subjects. Influence of magnetically-induced E-fields on cardiac electric activity during MRI: A modeling study.

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By examining these examples we wanted to highlight how the first approach may be associated with shorter surgery time, fewer overall hospital days, faster refeeding and minor complications. No similar complication of VP shunting has been reported before. Uterine peristalsis shown on cine MR imaging using ultrafast sequence. Medial deviation of the distal descending colon is an inconsistant but highly specific finding. Inositol-requiring enzyme 1 (IRE1) (an upstream regulator of Xbp1) was required for PHLDA3 induction by Tm, whereas other pathways (c-Jun N-terminal kinase (JNK), protein kinase RNA-like endoplasmic reticulum kinase (PERK) and activating transcription factor 6 (ATF6)) were not.

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Contribution to the problem of extramedullary and asecretory forms In addition, 18 days after treatment, significant macrophage tumoricidal activity was observed only in the ADM/Lip-treated group. Microbiological testing of commercial ice cream in Messina as required by the Ministerial Ordinance of 11 October 1978

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A calmodulin-binding sequence has also been identified in the C-terminus of the Aplysia twitchin kinase. Aryl-copper(III)-acetylides as key intermediates in Csp2-Csp model couplings under mild conditions.

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None of the mammalian splicing factors that have been cloned corresponds to the yeast pre-messenger RNA splicing factors, the PRP proteins. Last decade has seen quick developments in the understanding of a new type of T lymphocytes, Th17 cells.

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Long term anti-plaque gingivitis and calculus effects of benzethonium chloride in beagle dogs. Teratogenic effects of cadmium acetate and sulphate upon development of the chick embryo. Di- and trisaccharides containing C-3 modified arabinofuranosyl residues. The uterine cavity was evacuated by suction curettage after delivery and plasma, BHCG was negative 4 weeks subsequently. We conclude that using primary TSH screening is more effective for mass screening in reducing false-positive and false-negative cases than the combined T4/TSH screening method.

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High frequency of K-ras mutations in spontaneous and vinyl carbamate-induced lung tumors of relatively resistant B6CF1 (C57BL/6J x BALB/cJ) mice. A 10 days Leucotrofina or Timolimfotropina administration induced in Wistar rats a rise of glycemia and liver glycogen content, and a decrease of glycogen-phosphorylase a activity.

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To investigate root-canal shaping with manual and rotary Ni-Ti files performed by students. Significant results were obtained by treating cells and tissues with original holograms which induced normal cell/tissue frequency accord. Moreover, we used a cut piece of the produced carbon material as working electrode in a standard electrochemical cell and, thus, demonstrating the capability of the system to respond to incident light in the visible and near-ultraviolet region and to generate a photocurrent.

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A subepicardial space appears early and it is populated by mesenchymal cells which seem to proceed at least partly from the epicardium. Nineteen out of 21 consecutive patients could be operated with this technique.

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Since the prognosis of infants with acute lymphoblastic leukemia (ALL) is so poor, it has been suggested that these leukemias may not be lymphoid in origin, but may originate from stem cell, myeloid, or megakaryocytic progenitors. The samples were collected from grains from 15 until 45 days post-anthesis (dpa). Migraineurs were randomly allocated to 2 groups receiving either verum acupuncture (VA) or sham acupuncture (SA) treatment. The lecture submits a survey of the most frequent primary congenital disorders of amino acid metabolism and discusses their diagnostic significance for clinical biochemistry, paediatrics and antenatal medicine. A model based on the calculation of probabilities in which the classification of AIDS patients was designed in three phases: early, intermediate and AIDS and established the relations of changes among the phases and included the economic costs of each of the treatments.

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A peptide containing the cysteine involved in the formation of intersubunit disulfide bonds linking 7S monomers into pentamers was isolated from the H chain of the 19S molecule and characterized. All patients who arrived with a psychiatric problem were studied with regard to the following variables: age, gender, diagnosis, time of arrival, referral, destination and application for compulsory admission. Data on sexual activity and contraceptive use was collected on the basis of self report at ages 14 and 15 years. These data suggest that Gag trimerization driven by the MA domain is an intermediate stage in normal virion assembly and that it relies, in turn, on an MA conformation dependent on the hydrophobic core of the molecule.

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However, no significant improvement of gallbladder function was demonstrated even when ESWL was successful.(ABSTRACT TRUNCATED AT 250 WORDS) Based on the anatomic distribution of the circumflex scapular vessels, the flap in the scapular territory can be taken much longer and wider than before. The peak level of expression of Noggin mRNA was observed at embryonic day 13 (E13), subsequently gradually declined at 1-3 months (P1-3M) postnatal, and was detected only at a low level at P18M. Similarly, the inner cell mass (ICM) cells in blastocyst outgrowths showed diffuse cytokeratin-specific fluorescence.

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Furthermore, covalent inhibition, which already led to the first high-quality probe for JNKs, might be further exploited for gaining selectivity and in vivo efficacy. Expression profiling studies showed significant alternations in expression of calcium channels and pumps in testes and concurrently Tmem203 deficient spermatocytes demonstrated significantly altered calcium handling. Methods are described for the in vitro generation and detection of antibody-secreting cells (PFC) from channel catfish. The magnitude of the blast cell response observed in efferent lymph in the case of grafts exchanged between cotwins was generally intermediate between that observed in responses to allografts and control autografts. Two of the children with precocious puberty had hypothalamic hamartomas, one had an optic glioma, and one had a history of hydrocephalus.

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The characteristics of computerised tomography of the skull are described, and differential diagnosis of other cystic space occupying lesions of the brain as seen on computerised tomography is discussed. Development of an on-line SPE-LC-ESI-MS method for urinary nucleosides: hyphenation of aprotic boronic acid chromatography with hydrophilic interaction LC-ESI-MS.

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A carbon dioxide laser coupled with a rigid ventilating bronchoscope has been used to treat 94 patients with symptomatic obstructing lesions of the trachea and main stem bronchi. There was no qualitative difference between furosemide and thiazides in the potentiation of anti-hypertensive action of captopril. Treatment of mouse L1210 leukemia cells in vitro with low levels of ethidium bromide followed 1 hr later by bleomycin produced a synergistic effect that was 8 fold greater than that expected from the additive cytotoxicity of each drug alone. A population of 2020 patients with breast carcinoma, including 575 premenopausal women, was analyzed. Although, in the north, offshore Nice, cohorts can be advected southwestward out of Ligurian basin, more to the south others are retained in the central eddy and may give the start to the spring bloom of this species.

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Purification and characterization of the DNA polymerase of human breast cancer particles. Effect of low temperatures on the morphological picture of the rabbit skin. In this study, adult Sprague-Dawley rats were bled over a period of time until they became anemic by hematologic parameters. Use of a control by an eleven year old with a neoplastic disease. Educational opportunities--contribution to continued professional education

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gastrocnemius ability to posttraumatic regeneration after x-ray radiation in the doses 20--30 Gy, has been studied in 64 non-inbred white male rats with the body mass about 200 g. Endovascular repair was carried out for non-ruptured, infrarenal abdominal aortic aneurysms.

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Molecular analysis of programmed cell death during senescence in Arabidopsis thaliana and Brassica oleracea: cloning broccoli LSD1, Bax inhibitor and serine palmitoyltransferase homologues. Urinary IL-6 was not continuously secreted but appeared as a series of similar peaks during the first 48 h after infection.

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Comparing Genomic Profiles of Women With and Without Fibromyalgia. Contribution to the experimental study of artificial respiration by the rocking bed Cigarette smoking (CS) and air pollution can both alter autonomic cardiac function, yet little has been reported on their combined effect on cardiovascular dysfunction. Removal of cell surface sialic acid by neuraminidase treatment unmasked the lectin receptor sites of invasive hybrids to the level of the corresponding sites of non- or low-invasive cells. Plasma beta-thromboglobulin (beta-TG) levels were also measured before and after each run.

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Confirmation of this linkage assignment provides further support for the concept of evolutionary conservation of the avian Z chromosome. The paper deals with the systemic comprehensive design of hardwarses for combined anesthesia, provides the principle of operation of apparatures for inhalation anesthesia, the pattern of the designed complex, as well as the functional properties of inhalation anesthesia equipment of different generations. Plasticity of the brain in respect of functional restoration after subarachnoid haemorrhage. Six of these tumors are well differentiated, and three are poorly differentiated.

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Inheritance of specific apolipoprotein E (apoE) alleles determines, in large part, the risk and mean age of onset of late-onset familial and sporadic Alzheimer disease. Predictors of subsequent schizophrenia spectrum disorders in vulnerable adolescents. Assessment of the techniques used for the repair of stress urinary incontinence (SUI) and anterior vaginal wall prolapse, as well as the incidence of intraoperative and postoperative incidents and complications.

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