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Funginoc (Ketoconazole)

Funginoc is an imidazole antifungal agent used in the prevention and treatment of a variety of fungal infections. It functions by preventing the synthesis of ergosterol, the fungal equivalent of cholesterol, thereby increasing membrane fluidity and preventing growth of the fungus. Funginoc was first approved in an oral formulation for systemic use by the FDA in 1981. At this time it was considered a significant improvement over previous antifungals, miconazole and clotrimazole, due to its broad spectrum and good absorption. However, it was discovered that Funginoc produces frequent gastrointestinal side effects and dose-related hepatitis. These effects combined with waning efficacy led to its eventual replacement by triazole agents, fluconazole, itraconazole, [voraconazole], and posaconazole. Funginoc and its predecessor clotrimazole continue to be used in topical formulations.

Other names for this medication:
Ketoconazole, Nizoral, Akorazol, Arcolan, Arcolane, Asquam, Biogel, Clarazole, Conazol, Daktagold, Daktarin, Dezor, Diazon, Dikoven, Eumicel, Extina, Funginoc, Fungoral, Ilgem, Kenazol, Kenazole, Ketazol, Ketokonazol, Ketolef, Ketovid, Ketozal, Liondox, Lizovag, Micoral, Micosin, Muzoral, Mycoderm, Noell, Orifungal, Oronazol, Panfungol, Perative, Phytoral, Pristinex, Tiniazol, Tinuvin, Xolegel, Yucomy, Zoloral,

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Progeny of the transplanted cells are found below the level of the blastopore in the early gastrula and eventually give rise to portions of the gut, as is their fate in normal development. In Pisum sativum, the RAMOSUS genes RMS1, RMS2, and RMS5 regulate shoot branching via physiologically defined mobile signals. Colitogenic Bacteroides thetaiotaomicron Antigens Access Host Immune Cells in a Sulfatase-Dependent Manner via Outer Membrane Vesicles. This novel surgical procedure proves to be a viable option for the diagnosis and treatment of hydrocele. The accumulation of organic acids and H2S coincided with the growth and metabolism inhibition of fungi and acidophilic bacteria.

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The data suggest that the rate of carbamoyl phosphate synthesis is dependent to a large extent upon the specific activity of the slowly and incompletely repressible synthetic enzyme, carbamoyl-phosphate synthetase A. The method described in this work is able to select molecules active against MAC. We found that expression of CD44, in particular variant forms of CD44 (CD44v), suppresses reactive oxygen species (ROS) levels by promoting the synthesis of reduced glutathione(GSH), a primary intracellular antioxidant. There are significant resource challenges to burn surgical care delivery in low and middle-income countries at baseline and only a few burn cost analysis studies from sub-Saharan Africa have been performed.

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There were three histological types: typical, atypical and malignant. A prototypical drug delivery device is described that is fitted with a 13-nm nanopore membrane and loaded with radio-labeled BSA. One of the most important goal in minor surgical procedures is to achieve proper and sufficient anesthesia and analgesia preoperatively, intraoperatively and in the immediate postoperative period.

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Functional correction of the lip musculature is best done at the same time as surgical correction of the skeletal-dental deformities. C3, factor B, and alpha-1-antitrypsin were determined in newborn infants with septicaemia and sclerema, associated with suspected infections, ABO or Rh incompatibility, and hyperbilirubinaemia of unknown origin, during and after treatment with exchange transfusion. The specificities of musculoskeletal injuries in older people pose a different diagnostic challenge from that in young people participating in the same activities. Co-administration of an equi-molar CNDP with some fluorinated pyrimidine preparations potentiated their antitumor activity. Substrate quantitation was achieved with a linear range of 2 orders of magnitude and a detection limit of approximately 7.0 x 10-20 mol.

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Illumination with photosynthetically active radiation caused a fast turgor loss and wilting in the middle segments of the epicotyls accompanied by accumulation of water in the intercellular cavities. An intensive 3-year intervention was implemented with school food service staff.

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introduced a method for determination of composition in AlGaN/GaN heterostructures from high-angle annular dark field (HAADF) images. The occurrence of these risk factors in the various surgical specialties has been assessed. This extraordinary feature appears to be essential not only for the association of these heterodimers but also for receptor binding by the glycoprotein hormones. Intraoperative joint gaps and mediolateral balance affect postoperative knee kinematics in posterior-stabilized total knee arthroplasty.

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In order to clinically evaluate the interactions of these spinal processes we performed in vitro-experiments, animal studies and clinical investigations on the compatibility and antispastic efficacy of spinally administered opiates and benzodiazepines. The authors further present some mechanistic insights into the protective role of NA supplementation. Complications related to the catheter insertion were previously reported in both techniques. A newly established anti-interleukin-2 receptor beta chain (P75) monoclonal antibody inhibits the induction of allo-specific cytotoxic lymphocytes in combination with anti-interleukin-2 receptor alpha chain (P55) monoclonal antibody.

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Sexual orientation of these females towards either sexually active males or estrous females was then investigated and related to levels of receptive and mounting behavior. Taking into consideration the communications of literature and the cases of the Radiologic Hospital of the University of Heidelberg, the authors describe the clinical manifestations of these tumors, their histology, their distribution to age and sex, their symptomatology and time of anamnesis as well as the therapeutic results. In vitro effect of acetylcholine on function of sinoatrial node in rat heart. Logistic regression was used to determine the effects of UV exposure on mortality, controlling for age, gender, race and other comorbidities. Time interval of the last dental visit in dental students at the Federal University of Bahia

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Scores on the scale were uncorrelated to death anxiety in a sample of 168 students. A thorough knowledge of the current applications of CT angiography with respect to the peripheral vasculature is essential for the endovascular specialist.

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Organization and nucleotide sequence of the human KIT (mast/stem cell growth factor receptor) proto-oncogene. Twelve three-dimensional (3D) models were designed in SolidWorks of the anterior segment with four and six teeth and their supporting structure. Human immunodeficiency virus (HIV) is lymphotropic and neurotropic. Myelin microvacuolation in thalamus, hypothalamus, and fornix were noted histologically after 4-5 weeks of treatment.

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Combined docetaxel and estramustine improves survival in patients with castration-resistant prostate cancer. Posttransplant LA (AA precursor) significantly prolonged graft survival. Halothane interference at an amperometric oxygen electrode: the development of an oxygen/halothane sensor.

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Avoiding axillary dissection in breast cancer surgery: a randomized trial to assess the role of axillary radiotherapy. Monkey interleukin 2: optimal conditions for production and partial characterization. Future directions: a time for establishing goals and priorities. A quantifiable method of evaluation is proposed here, based on how much of the overall variance is removed from the data.

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Preservation of the functional activity of the masticatory muscles in bimaxillary fixation of mandibular fractures PF-LCP represents a feasible alternative for treatment of unstable inter- or subtrochanteric fractures. Measurement of the pressure in the ascending lumbar vein at rest revealed a progressive rise of the mean pressure from the control group to the lumbar intervertebral disc herniation group, and the lumbar spinal canal stenosis (LSCS) group in ascending order.

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The incidence of certain dental anomalies is strongly correlated with Cleft lip and palate, a finding that is consistent with previous studies. In 21 patients the disease progressed in spite of the treatment. In addition, when the head is tilted, it contributes to maintain horizontally the plane of the gaze.

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Whereas recombination is well documented in other members of this family, the extent of recombination has so far not been studied in RHDV. These results suggest that the three NF proteins may be unequally distributed within the soma and processes of different types of neurons and/or may be subject to regionally selective modification. These features confer numerous potential functions to circRNAs, such as acting as microRNA (miRNA) sponges, binding to RNA-associated proteins to form RNA-protein complexes and then regulating gene transcription. It is hypothesized that lower serum PEP activity may play a role in the biophysiology of fibromyalgia through diminished inactivation of algesic and depression-related peptides. Serum autoantibodies in systemic lupus erythematosus and correlation with cutaneous features.

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xanthus strains were isolated with Tn5 insertions at various positions in the DNA which codes for protein S. In addition, preliminary studies were performed to understand the effect of centrifugation and filtration of urine on its protein contents. Forty-three patients being evaluated for the presence of clinical tuberculosis received careful simultaneous cutaneous tests with intermediate-strength tuberculin, comparing reactions elicited with intradermal tests to those elicited by subcutaneous tests.

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Aminopeptidase N is directly sorted to the apical domain in MDCK cells. A critical component of an effective HIV vaccine will be the induction of broadly neutralizing antibodies. Trigeminal Neuralgia Caused by Venous Angioma: A Case Report and Review of the Literature. Proceedings: Influence of higher incubation temperature on spontaneous and induced chromosome instability.

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All parameters are to be read off the tomogram without calculations or further operations. Depletion of Leu-2 positive T cells from reconstituted autologous PBMC cultures resulted in an increase in SAC-stimulated IgM production in the majority of individuals, implying the involvement of Leu-2 positive suppressor T cells in this system. 2-Aminopurine, an inhibitor of dsRNA-dependent kinase, suppressed the induction of ENA-78 by poly IC. Thiobarbituric acid-reactive species were formed from phosphatidylcholine after UVA radiation in vitro.

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Within the PILO saliva samples, there was a very strong positive correlation between the mucin content of saliva and the mucin content in the pre-secretory gland prior to stimulation. Gloves can prevent infection but their use among student nurses is inconsistent. These findings suggest a role for GAL in the transmission of visceral sensory information by the vagus nerve in rats. Here, we examined whether this gene also plays a role in regulating cell death under abiotic stress.

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The average peak skin reactions of the wound dressing gel-treated mice were lower than those of the untreated mice at all radiation doses tested. It is clear that nitric oxide does not act only on systemic blood vessels under physiological conditions.

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Plasma lipids, glucose, and insulin levels were decreased by starvation and returned to the levels before starvation between 8 and 24 h after refeeding. After the third cycle of immunotherapy, a CT scan showed a remarkable regression of the lung metastases. Correlated effects of selection for immunity in White Leghorn chicken lines on natural antibodies and specific antibody responses to KLH and M. Method of determining the class of hazard of a sum of industrial fluid vapors and aerosols in the air of a work area

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Surviving low-birthweight infants (despite surfactant therapy) remain at risk for the consequences of premature birth, such as neurosensory impairment, cerebral palsy, and chronic lung disease. The literature regarding the unclear histogenesis of this distinctive tumor is reviewed. Medical resource use and costs among rheumatoid arthritis patients receiving disease-modifying antirheumatic drug therapy. From this series of 10 patients we conclude that the biologic behavior of vaginal carcinoma in situ following carcinoma of the cervix resembles that of carcinoma in situ of the cervix and that carcinoma of the vagina following carcinoma of the cervix should be considered a separate clinical entity distinctive from primary invasive carcinoma of the vagina. These exchanges enhance the transactivation property of the receptors, particularly to androsterone and androstanediol, 2 metabolized derivatives of testosterone present in the prostate.

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The sensitivity and specificity of the individual tests indicate that total catecholamines is marginally the best single test to perform when trying to diagnose neuroblastoma, with the best clinical sensitivity being achieved by examining both total catecholamines and HMMA. Neither heparin nor poly-L-glutamate affected vagally induced responses in control animals. Angiotensin II and eicosanoids in the control of glomerular size in the rat and human.

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Our results provide evidence for two complete representations of the body surface. Future study should investigate methods to improve ED management of these patients. The drug infusion was accomplished by an osmotic minipump implanted under the skin and attached to the jugular vein, which delivered drug or vehicle over a period of 24 hours.

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The historical development of the relationship between paediatrics and child psychiatry is outlined and the closer working relationships between the two disciplines over the past 30 years are noted. Interpersonal behavior in group discussion during marijuana intoxication.

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Water-compatible silica sol-gel molecularly imprinted polymer as a potential delivery system for the controlled release of salicylic acid. Systolic pressure and epinephrine and norepinephrine levels, tyrosine hydroxylase activity, and tyrosine hydroxylase mRNA levels in the adrenal medulla of WKY showed no significant differences among the control, castrated, and testosterone-replaced groups.

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We have identified 11 proteins in lysates of human A375 melanoma cells, including: alpha-enolase, cytokeratin, stathmin, protein disulfide isomerase, tropomyosin, Cu/Zn superoxide dismutase, nucleoside diphosphate kinase A, galaptin, and triosephosphate isomerase. Our method of abdominal wall reconstruction in the prune-belly syndrome produces a cosmetically excellent and durable result.

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Thus, it is premature to extrapolate these findings to human PKD. Group B and AB sera, acting on O red cells in the presence of UDP-galactose, each converted them into B active cells, which were agglutinated by anti-B human serum (1:512) at the titer of 128-fold, while group Bm and A-1 Bm sera, converted O red cells similarly incubated into B active cells, which were agglutinated by anti-B human serum (1:512) at the titer of 8- to 16-fold. Inhibitory effects of various oxygenated sterols on the differentiation and function of tumor-specific cytotoxic T lymphocytes. Differences in the shape of the piriform aperture between Pan and Gorilla were explained by differences in orientation of elongation (phase of the second harmonic) and by differences in the component of triangularity (amplitude of the third harmonic).

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Cryopreservation versus subcutaneous preservation of autologous bone flaps for cranioplasty: comparison of the surgical site infection and bone resorption rates. Possible relationship between membrane proteins and phospholipid asymmetry in the human erythrocyte membrane.

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Quality evaluation of honey harvested from selected areas in Tanzania with special emphasis on hydroxymethyl furfural (HMF) levels. A case of multiple gastric diverticula with pyloric stenosis is reported here. We have used a step increase in target plasma propofol concentration in head injured patients to explore flow-metabolism coupling in these patients.

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We present a case where a Danish man was referred to our outpatient clinic with lower urinary tract symptoms. The total patient material was divided into groups depending on diagnosis: 47 patients with rheumatoid arthritis, 27 patients with arthritis of different etiologies, 15 patients with non-inflammatory diseases and 7 patients with arteritis. A novel organotypic culture model for normal human endometrium: regulation of epithelial cell proliferation by estradiol and medroxyprogesterone acetate.

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Two studies show that in utero exposures influence the future development of hypertension. Escherichia coli and Vibrio cholerae strains deficient in an enzyme involved in disulphide bond formation (DsbA) show an increase in sensitivity to dithiothreitol. The expression of HOXA5 and HOXA9 genes of bone marrow samples from 75 newly diagnosed AML patients and 22 healthy controls for comparison were examined by Real- time quantitative PCR (RQ-PCR) assay.

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There were eight non-unions in the open, uninfected fractures, five of which healed after bone-grafting. Ten intramedullary and two intradural extramedullary masses of the spinal canal were evaluated with 16 separate needle aspirations. Relationships between pulmonary inflammation, plasma transudation, and oxygen metabolite secretion by alveolar macrophages. We compared healthy blood donors with and without HLA-Dw2 and -Dw3 in immunity assays, the results of which have been found to be abnormal in multiple sclerosis or autoimmune diseases.

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A KcsA channel with a gold nanocrystal attached was irradiated by white X-rays and motions of the diffraction spot from the nanocrystal were tracked in real time. The H antigen elicited the characteristic agglutinin response to a protein antigen--early production of 19S globulin followed by persistent 7S globulin production.

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The high protein diet-fed group had greater liver weight and zinc and GSH concentrations after TNF than the group fed the low protein diet supplemented with alanine. luminescens HW luciferase was unusual among known luminous bacterial systems. Moreover, papaverine may partially cause catecholamine release from adrenergic nerve fibers and it may inhibit the adenosine uptake mechanism. Degeneration of the cartilage was observed around the cellular accumulations. Preferential inhibition of ribonucleic acid synthesis by a new thiosemicarbazone possessing antibacterial and antiparasitic properties.

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The tendency of Blacks to report fewer painful symptoms and to attribute their symptoms to noncardiac origins may contribute to differences in care-seeking and in medical management of heart disease in Blacks. According to this model, ion regulation in distal paranodal axon regions is compromised by diminished axolemmal Na/K-ATPase activity. Ten patients with recurrent squamous cell carcinoma of the head and neck received daily injections of interleukin-2 (IL-2) from the Jurkat T-cell line purified by high pressure liquid chromatography for 10 days.

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This paper reviews the subject and presents preliminary results of a two-stage study of the prevalence of use of alternative medicine in a south London practice. The repair of ultraviolet light-induced potentially lethal damage was investigated in density-inhibited skin fibroblast cell strains derived from patients with systemic lupus erythematosus. The residual SYNTAX score (after angioplasty) is an independent predictor of clinical long-term outcome in patients with complex coronary artery disease. Induction of the regeneratory reactions of the bronchial epithelium with synchronously developing reorganization of the stroma (loosening of the connective tissue and stimulation of its vascularization) is shown during correction of asthma.

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The binding of technetium-99m sulfur colloid to in vivo thrombi was studied in a rat model of deep vein thrombosis. Nevertheless, low cholesterol is more favourable than high cholesterol for most aspects of cell function. While this antibody binds to a type II IL-1 receptor positive cell line, it can be shown that it does not bind to the type II IL-1 receptor. Ethibloc embolisation, which fills the capillaries, is as effective as nephrectomy, whereas ligature of the renal artery fails to affect the hypertension.

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