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Clarazole (Ketoconazole)
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Ketoconazole

Clarazole is active against Candida spp., and Cryptococcus neoformans. However, its activity is limited compared to that of fluconazole and itraconazole. Furthermore, due to its limited penetration to cerebrospinal fluid, it is clinically ineffective in meningeal cryptococcosis. Its activity against the dimorphic moulds, Histoplasma capsulatum, Blastomyces dermatitidis, Coccidioides immitis, Sporothrix schenckii, Paracoccidioides brasiliensis, and Penicillium marneffei is favorable. However, fluconazole and itraconazole are at least as effective as Clarazole against these fungi and are safer. Thus, Clarazole remains as an alternative second-line drug for treatment of infections due to dimorphic fungi. Clarazole is not recommended for treatment of meningeal infections due to Histoplasma capsulatum, Blastomyces dermatitidis, and Coccidioides immitis due to its limited penetration to cerebrospinal fluid. Clarazole is also active against Pseudallescheria boydii and is a good alternative for treatment of pseudallescheriasis. It is also effective in pityriasis versicolor. Clarazole has practically no activity against Aspergillus spp., Fusarium spp., and zygomycetes order of fungi.

Other names for this medication:
Ketoconazole, Nizoral, Akorazol, Arcolan, Arcolane, Asquam, Biogel, Clarazole, Conazol, Daktagold, Daktarin, Dezor, Diazon, Dikoven, Eumicel, Extina, Funginoc, Fungoral, Ilgem, Kenazol, Kenazole, Ketazol, Ketokonazol, Ketolef, Ketovid, Ketozal, Liondox, Lizovag, Micoral, Micosin, Muzoral, Mycoderm, Noell, Orifungal, Oronazol, Panfungol, Perative, Phytoral, Pristinex, Tiniazol, Tinuvin, Xolegel, Yucomy, Zoloral,

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Analysis of the N-terminal amino-acid sequence of the chitinase, and comparison with that deduced from the nucleotide sequence, revealed post-translational processing of a putative signal peptide of 22 amino acids and a second peptide of 12 amino acids. The application to smooth muscle cells of the rabbit ear artery, of either K ions after incubation with K-free solution, or of ACh produced a transient hyperpolarization of the membrane.

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The relationship of P cells to mast cells and Ia-positive accessory cells and their possible role in T cell activation is discussed. These data indicate that in growing cells of this yeast the mechanism responsible for the activation of trehalase can be independent of interactions with free catalytic subunits of PKA and related to a signaling pathway involving a type of protein kinase different from PKA. Non-HLA genomics: does it have a role in predicting haematopoietic stem cell transplantation outcome? The type and amount of organic contaminants also affected the pozzolanic reactions.

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Nevertheless, they present adverse effects such as hypokalemia or hyperkalemia. Effects of repetitive pulsing on multi-kHz planar laser-induced incandescence imaging in laminar and turbulent flames.

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Moreover, many microglias/macrophages showed PCNA positivity, indicating they proliferated locally. In vivo, exogenously elevated vitreal ET-1 significantly affected protein composition of FAxT-cargos as well as the abundance and peak delivery times for metabolically-labeled proteins that were transported into the optic nerve.

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To evaluate the relationship between PA domains, PA guideline adherence, and weight history on MHO. Hepatitis B infection of children in a mixed-race community in western New South Wales. Socio-demographic characteristics of HIV-exposed and HIV-infected Jamaican children.

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We enrolled 54 patients with AF and having symptoms despite medical therapy. Analysis of perfluorinated carboxylic acids in soils II: optimization of chromatography and extraction. These materials are high-k dielectrics with degenerate or thermally activated n-type semiconductivity. The catheter position and extent of drug distribution were controlled by injection of dye and dissection of the spinal canal. The laryngeal mask airway is recommended for paediatric outpatient dental anaesthesia.

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Formation of amyloid-like fibrils in COS cells overexpressing part of the Alzheimer amyloid protein precursor. Clinically indicated DFT testing, as expected, has a high yield of important information on device function in congenital heart disease and pediatric populations. Bacterial growth can be supported in iohexol under certain circumstances, due to the lack of preservatives in this contrast material.

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Totally tubeless double-access PCNL is feasible and bleeding complications are comparable to single access totally tubeless PCNL making it an effective strategy to achieve more stone free rates. In this review article, we describe the currently available methodologies for the computational estimation of FFR, present evidence derived from their clinical evaluations, stress their limitations, and discuss their potential value in clinical practice. However, no clear correlation between bronchoconstriction and cough reflex was found in the experimental model used for this study. DNA probe technology for rapid detection of Haemophilus influenzae in clinical specimens.

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There is a need to develop lubricants and identify lubrication methods that are suitable for MEMS/NEMS. TGF beta inhibits gonadotropin action both in Sertoli cells and Leydig cells as well as proliferation of germ cells and Leydig cells. Use of the internet for health care information: results from a national telephone survey The facilitation of RMA and spontaneous episodes could not be explained only by the increased amount of relaxed wakefulness, i.e.

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To explore whether basic bladder advice has any effect against nocturnal enuresis. Efficacy of 3,4,3-LIHOPO for reducing the retention of uranium in rat after acute administration. The intraductal approach offers the possibility to directly sample fluid containing cells, DNA and proteins from the mammary ductal system where, in the majority of cases, breast cancer originates. This seems to be responsible for partial or total resistance of irradiated animals to the regulatory effects of neurotransmitters. Ictal brain SPECT was performed on 14 patients and in the remaining 23 patients a postictal SPECT was obtained.

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Overexpression, immobilization and biotechnological application of Pseudomonas lipases. Hepatic microsomal metabolism of CCL4 after pretreatment with chlordecone, mirex, or phenobarbital in male rats.

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Electron microscopy and optic diffraction methods were used to determine the main parameters of the morpho-structural organization of cholera phages 493 and 7227. Age-associated changes in specific errors on the Benton Visual Retention Test. The sequence of this clone confirmed that the published sequence was incorrect and demonstrated that the right telomere region of chromosome III is similar to other telomeres. Peptide mapping and tunicamycin treatment has identified that groups 1 and 2, and 3 and 4 are closely related and that groups 1 and 3 arise by N-glycosylation of 2 and 4, respectively.

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Blood pressure development in young spontaneously hypertensive rats is also unaffected by long-term administration of endothelin antagonists. The primary endpoint was change from baseline at week 24 in glycated haemoglobin (HbA1c).

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Nonketotic hyperosmolar hyperglycemic coma in the early period of emergency CABG surgery We compare our model to the models of other investigators and argue that our model is especially useful to practitioners. After 30 min of ischaemia, circulation was restored by removing the arterial clamps and increasing blood pressure to preischaemic levels.

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This may also be true for young children treated with CAPD, since IgG2 deficiency has been established for children. Alteration of proteins expression in apoptotic FL cells induced by MCLR. Concentration of copper increased and concentration of zinc decreased in liver of sheep with increasing dietary manganese. Receptor site specificity for the acute effects of beta-N-methylamino-alanine in mice.

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It shows that amantadine induces AADC gene expression at concentrations of 10 and 100 microM after 24 hr of incubation. Tribenoside thus also exerts a membrane-stabilizing action on red cells.

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Early developmental stages of the hindlimbs in chelonian embryos Testuda graeca L. Thus, when it is difficult to localize a cancer, brushing of the peripheral bronchi beyond bronchoscopic visibility and chest computed tomography should be performed. MSCs were isolated from the bone marrow of allogenic mice and identified by flow cytometry.

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This may also explain the infrequency of serious complications among migraine patients. The palatal movement of the apices of upper incisors using intra-oral elastics: a case report. Multiple family therapy: a new direction in the treatment of drug abusers. This article presents a systems model of inputs, processes, and outcomes with explication of factors related to client, provider, and setting as a heuristic strategy for variable specification.

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Decreased density of synaptic formation in the frontal cortex of neonatal rats exposed to ethanol in utero. Combined chemotherapy with carmustine, doxorubicin, etoposide, vincristine, and cyclophosphamide plus mitoxantrone, cytarabine and methotrexate with citrovorum factor for the treatment of aggressive non-Hodgkin lymphoma: a long-term follow-up study. Animals treated with 50 mg/kg of endotoxin neutralizing protein 60 mins after E. The insertion of arterial lines has become a routine procedure for the critically ill. Dynamic study after one and two weeks showed no enhancement in the necrotic region.

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Apnoea lasted twice as long with propofol as with the flunitrazepam-propanidid association (p less than 0.001), whereas recovery was twice as quick (p less than 0.001). After cellular calcium depletion, dose-response curves to extracellular calcium, in the presence of 10(-5) mol/L serotonin, were unchanged in thoracic or abdominal aortas among the three groups. Evaluation of the brachial artery to brachial vein bovine heterograft arteriovenous fistula for hemodialysis. Lethal mutations induced in Drosophila melanogaster by direct or indirect action of pteridines. We are currently developing Meaning-Centered Psychotherapy for Cancer Caregivers (MCP-C).

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Risk Factors for Recurrent Clostridium difficile Infection in Children: A Nested Case-Control Study. Soluble protein of the organic matrix of mollusk shells: a potential template for shell formation. Pathological life and death: medical spatialisation and geriatrics. Extravascular circulation of lipoproteins: their role in reverse transport of cholesterol.

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The Attention Network Test (ANT) assesses attention in terms of discrepancies between response times to items that differ in the burden they place on some facet of attention. Accuracy and performance of the Terumo ES-H51, a new portable blood pressure monitor. The authors documented the evolution of common bile duct (CBD) evaluation after the development of laparoscopic cholecystectomy (LC) and CBD exploration. The function of these antigens is unknown but the I antigen has a decreased expression and the i antigen has a concomitant increased expression in conditions that result in increased hematopoiesis. Nested PCR with three highly degenerate primers was used for amplification and identification of DNA polymerase (pol) genes from viruses which infect three genera of microalgae.

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Vascular endothelial cells cover the entire inner surface of blood vessels in the body. Twenty-one endoscopists attending an endoscopic resection workshop.

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Corticotropin releasing factor (CRF)-containing afferents to the rat lateral septum (LS) have been determined by means of cobalt-enhanced immunohistochemistry, tracing of retrograde transport of horseradish peroxidase (HRP), and by lesioning experiments. The diagnosis was histologically confirmed by vitreal sample or brain biopsy. Such genomic repeats can be used as homologous regions for integration of plasmids. The medical model or disease concept approach to substance abuse treatment is practiced in most residential substance abuse treatment programs. These patients had segmental T2-hyperintense lesions in the central gray matter of the cervical spinal cord on MRI.

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Delta infections occur in two circumstances: co-infections where both viruses are acquired simultaneously, and superinfections where delta virus infects a patient who is already a chronic carrier of hepatitis B virus. Heart-blood-pool scintigraphy in dialyzed chronic uremic patients) A rapid modified procedure for the gas chromatogrpahic determination of esterase activity was studied. It has generally been thought that the cause of symptoms in Moyamoya disease is rupture of vessels in the subarachnoid space on the cerebral cortex. Laser surgery has shown to exhibit several advantages over scalpel for many procedures.

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Fentanyl (10 and 30 mug/kg), a narcotic analgesic, induced in cats a decrease in blood pressure and heart rate and reduced spontaneous splanchnic nerve activity. Acute myeloid leukemia with T-lymphoid features: a distinct biologic and clinical entity.

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Bone formation with heparinized plastic implants in rats--a methodological study. The antigen HLA-A2 was associated with pauciarticular JRA in girls.

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When C3H/He mice were treated with lipopolysaccharide, poly(I) X poly(C), or pokeweed mitogen, the serum interferon titer increased almost instantaneously (100-2000 units/ml), and then the pulmonary indoleamine 2,3-dioxygenase was induced 50- to 140-fold. We then assessed the women for strengths, adverse social behavioral circumstances, posttraumatic stress disorder (PTSD), and depression. Invagination of the small intestine in the early postoperative period Hypocalcemic effect of osteoclastogenesis inhibitory factor/osteoprotegerin in the thyroparathyroidectomized rat.

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Diet Soft Drink Consumption is Associated with the Metabolic Syndrome: A Two Sample Comparison. Selective inhibition of anti-nucleoside-specific antibody production by nucleoside-ricin A conjugate. As a result, it represents a major problem in drug development and safety.

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Although the Barron Ego Strength Scale (BESS) often has been shown to differentiate between the presence or absence of psychopathology, the exact construct measured as Ego Strength is little understood. Temporal and concentration effects of isoflurane anaesthesia on intestinal tissue oxygenation and perfusion in horses. In a previous study we showed that the magnesium-calcium ratio of tap water is negatively correlated with the incidence of calcium-containing urinary stones. In the present pilot study, MS was associated with more positive changes than BAT.

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In metazoans, integrins are the major adhesion receptors that connect cells to components of the extracellular matrix. Short repeated sequences are interspersed with single copy sequences and are poorly base paired. The EQ-5D-5L questionnaire seems adequate to provide utilities and DWs in patients with melanoma.

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There was no relationship between therapeutic response and either plasma antidepressant levels or pre-treatment CSF nevimune drug information monoamine metabolite levels in his small group of patients. One-sample proportion test with chi square statistics was used for analysis. Such events, for example, recombine structurally independent functional domains and shuffle targeting, regulatory, and/or catalytic functions.

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A review of 1200 patients with craniofacial injuries treated at the Dental Surgical Consultation Clinic of the Krakow Provincial Dental Outpatient Clinic It has been proposed that alterations of the balance between programmed cell death and cell replication might be involved in abnormalities of imacillin vs amoxicillin and clavulanate smooth muscle cell growth in arterial hypertension. Details of plant performance during performance testing and during the first three years of plant operation are provided.