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Ciclofosfamida (Cyclophosphamide)

Ciclofosfamida remains one of the most successful and widely utilized antineoplastic drugs. Moreover, it is also a potent immunosuppressive agent and the most commonly used drug in blood and marrow transplantation (BMT). It was initially synthesized to selectively target cancer cells, although the hypothesized mechanism of tumor specificity (activation by cancer cell phosphamidases) transpired to be irrelevant to its activity. Nevertheless, Ciclofosfamida's unique metabolism and inactivation by aldehyde dehydrogenase is responsible for its distinct cytotoxic properties. Differential cellular expression of aldehyde dehydrogenase has an effect on the anticancer therapeutic index and immunosuppressive properties of Ciclofosfamida. This Review highlights the chemistry, pharmacology, clinical toxic effects and current clinical applications of Ciclofosfamida in cancer and autoimmune disorders. We also discuss the development of high-dose Ciclofosfamida for BMT and the treatment of autoimmune diseases.

Other names for this medication:
Cyclophosphamide, Cytoxan, Ciclofosfamida, Cryofaxol, Cycloblastin, Cycloxan, Cycram, Endoxan, Endoxana, Genoxal, Neosar, Procytox, Sendoxan,

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A description of the important aspects of the interface software design is presented in this paper. The HLA-D-DR associations previously described in European and North American Caucasians were also found in Asian Indians. Glucose and energy-metabolism and survival of Babesia rodhaini in a basal medium with and without adenosine. Incidence of ano-genital and head and neck malignancies in women with a previous diagnosis of cervical intraepithelial neoplasia.

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We found significant changes in day-night melatonin levels during convulsions, consistent with the hypothesis that melatonin has an inhibitory function on central nervous system activity. Ibopamine kinetics after single and multiple dosing in patients with congestive heart failure. Lipopolysaccharide and interleukin 1 inhibit interferon-gamma-induced Fc receptor expression on human monocytes. In conclusion, hypoxia appears to play an important role in the pathogenesis of endometriosis and endometriosis-associated angiogenesis, and the angiogenesis inhibitor 2-methoxyestradiol may be a potential candidate for systemic treatment in the future.

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Wearable red-green-blue quantum dot light-emitting diode array using high-resolution intaglio transfer printing. Moreover, its association at the NE with lamin and emerin, the genes mutated in Emery-Dreifuss muscular dystrophy, suggests a mechanism to explain how disruption of the NE leads to muscle dysfunction. Stalk cell differentiation has characteristics of autophagic cell death, a process that also occurs in higher eukaryotes. Adjustment of a rapid method for quantification of Fusarium spp. On the scene: maximizing nursing practice at Harborview Medical Center.

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The question of using prespeech oromotor training to reduce possible future dysarthria is discussed in terms of the findings. We hypothesize that low concentration of AS could enhance metastasis and proliferation of transformed cancer cells by promoting EMT. The implications of the findings were discussed with respect to the state-dependent hypothesis. Short-term withdrawal from developmental exposure to cocaine activates the glucocorticoid receptor and alters spine dynamics. The actions of these analogues were also investigated on the isolated guinea-pig ileum and the rabbit oviduct in vivo.

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The use of numerical and graphical statistical methods in the analysis of data on learning to see complex random-dot stereograms. Medical treatment has been directed toward preventing inflammation, the first phase of the wound healing process, and inhibiting cell proliferation, the second phase. The effect of hyperthermia on DNA strand break repair was studied in CHO cells.

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Collagen synthesis was also estimated and results compared with normal skin fibroblasts. All the properties found for binding of proteins to isolated envelopes are consistent with the concept of the so-called envelope carrier hypothesis.

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The effect of laterality of cerebral lesion on sequencing ability, which is an ability to process two or more stimulus events with respect to the order in which they occur, was examined. The epidural technique was performed successfully at the L5-S1 interspace using the loss-of-resistance technique after two failed attempts at the L3-4 interspace. This paper describes assessment of trainers and training practices by a team of general practitioners who visit for one day. Previous studies searching for causative mutations in NKH patients have only looked for a limited number of specific mutations or only screened part of the gene, and in many cases either no mutation or only one mutation was found, which is of limited use for prenatal diagnosis.

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Spontaneous pneumothorax heralding metastasis of admantinoma of the tibia. In vitro biosynthesis of human chorionic follicle stimulating hormone. Integrative network analysis methods provide robust interpretations of differential high-throughput molecular profile measurements. Rats were trained to choose the correct odour in a pair to be rewarded with drinking water. They also suggest that although a possible augmentation of the hypothalamic LHRH release at the preovulatory phase cannot be denied, a series of endocrine events during the human menstrual cycle may be regulated by the feedback action of the ovarian signals on the pituitary under a fixed input of the hypothalamic LHRH.

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Angiotensin I-converting enzyme (ACE) is crucial in the renin-angiotensin-aldosterone system. Enhancement of epidermal regeneration by biosynthetic epidermal growth factor. Mucin-hemoglobin did not augment HITB growth, but impaired macrophage adherence to glass in vitro, without decreasing cellular viability. Adjuvant therapy for breast cancer patient with 10 or more involved nodes

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The cross-sectional study was conducted from September 2011 to June 2012 and comprised nurses employed in the paediatric departments, consisting of neonatal intensive care units and newborn units, of 15 hospitals in various cities of Turkey: 8 in Istanbul, 3 in Izmir and two each in Antalya and Edirne. Taken together, our results show that these two viral glycoproteins have different maturation kinetics in the ER. The morphological characteristics and the internal transcribed spacer sequences of rRNA of the pathogen isolated from the sclerotinia rot showed it to be S.

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Cooperation of murine F T and parental B lymphocytes in rejection of a xenogeneic tumour: adaptive differentiation of B lymphocytes? The main part of the interfering compounds arising in organic extracts have a polarity similar to cortisol, which cannot be easily eliminated by simple solvent extraction procedures. CD59 did not stain all cells of the lesion and in particular did not appear to stain all smooth muscle cells. The Wcbf2 transcript accumulated rapidly after LT treatment and remained at a high level in lines without any dominant Vrn-1 alleles.

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A more detailed investigation of the factors that affect epoxide formation indicates that active sites within the injector are responsible for the degradation and that the reaction is temperature dependent. The difference is most pronounced when different eigenmodes possess similar group velocities and when their field patterns vary as a function of frequency. In combination of acetylcholinesterase (AChE) staining and VIP immunohistochemistry, AChE-positive and VIP-immunoreactive nerve fibers reveal almost same distribution in the same specimen.

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Gardner-Rasheed feline sarcoma (v-fgr) oncogene homolog (FGR), alpha-L-fucosidase 1 (FUCA1), and fibronectin 1 (FN1), and the microsatellite loci ARO28, DU17S2, DU17S3, DU17S4, and DU17S5. Using a canine local skin assay, we tested transfer factor prepared from three subpopulations of human peripheral blood mononuclear cells. Familial cases of progressive external ophthalmoplegia, deafness, generalized weakness, and hypogonadism were studied. Plasma cytokine clearance, immunological and physiological effects and safety parameters of HCO membranes.

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